Serum Bactericidal Activity in Patients with Upper and Lower Urinary Tract Infections

Gower, P. E.; Taylor, Peter W.; Koutsaimanis, K. G.; Roberts, Adrienne

doi:10.1042/cs0430013

Cited by 40 publications

(26 citation statements)

References 13 publications

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“…Serum resistance It has been claimed that the ability to resist the bactericidal activity of serum was present more often in pyelonephritis E. coli strains than in ABU strains (Gower et al 1972;Olling et al 1973;Bjorksten & Kaijser, 1978), and that it was significantly correlated with haemolysin production and with 0 types 0 4, 0 6, 0 18 and 075 (Hughes, Phillips & Roberts, 1982). For further information on serum resistance see under bacteraemia.…”

Section: Haemolysinmentioning

confidence: 99%

Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

220

161

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When Theodor Escherich (1885a, b) first describedEscherichia colihe looked on it as a saprophytic organism. Soon several investigators found that colibacteria could be isolated from intestinal infections and from many infections outside the intestine, like urinary tract infections (UTI), cholecystitis, wound infections, meningitis, septicaemia, pulmonary infections, and many more. Uhlenhuth (1897) showed that coli strains from pathological processes were more pathogenic in animal experiments than strains isolated from the normal intestine. Smith (1927), who examined strains from white scours in calves, showed that spontaneous acapsular mutants could be obtained from certain colibacteria, and that such mutants were less virulent when injected intra-peritoneally into guinea-pigs.

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Section: Haemolysinmentioning

confidence: 99%

Escherichia coliin extra-intestinal infections

Ørskov

1985

J. Hyg.

220

161

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“…Although renal parenchymal infection is reputed to cause high agglutination or haemagglutination titres to the 0 antigen of homologous infecting E. coli, while lower urinary tract infection is said to result in low titres (Percival et al, 1964;Andersen, Hanson, Lincoln, 0rskov, 0rskov, and Winberg, 1965;Vosti, Monto, and Rantz, 1965), unless other tissues such as prostate are involved, this has been found unreliable (Gower, Taylor, Koutsaimanis, and Roberts, 1972) and it cannot be the whole story. E. coli infection in the isolated bladder pouch of the dog results in 0 haemagglutination titres comparable to those reached in renal infections (Darwish, Staubitz, Scheuller, Rubin, and Neter, 1968).…”

Section: Discussionmentioning

confidence: 99%

The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

Marsh¹,

Banerjee²,

Panchamia³

1974

J Clin Pathol

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“…Among strains of the eight 0-types most frequently causing such infections at this hospital, 04, 09, and 018 had a high incidence of multiple resistance (35, 22, and 19%, respectively); 02 and 06 had an intermediate incidence (14 and 11'1c', respectively); and 07, 01, and 075 had a low incidence (8,6, and <3,c respectively). This nonrandom distribution appears to be a consequence of unequal plasmid recipient ability.…”

mentioning

confidence: 84%

“…This distribution is important as it dictates the effectiveness of hospital chemotherapeutic practice and because R-plasmid carriage may influence bacterial sensitivity to serum (17,22,24), a characteristic which appears to be important in urinary tract pathogenesis (6,13,15,23).…”

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confidence: 99%

Spread of R-plasmids among Escherichia coli causing urinary tract infections

Bauer¹,

Roberts²

1981

Antimicrob Agents Chemother

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The incidence of multiple-antibiotic resistance among Escherichia coli isolated from urinary tract infections at Charing Cross Hospital, London, increased over the last 10 years, and its distribution was related to 0-type. Among strains of the eight 0-types most frequently causing such infections at this hospital, 04, 09, and 018 had a high incidence of multiple resistance (35, 22, and 19%, respectively); 02 and 06 had an intermediate incidence (14 and 11'1c', respectively); and 07, 01, and 075 had a low incidence (8,6, and <3,c respectively). This nonrandom distribution appears to be a consequence of unequal plasmid recipient ability. After overnight mating with antibiotic-resistant donors, R-plasmid infection frequencies among antibiotic-sensitive urinary tract isolates differed by up to 105_fold, and such differences were correlated with the variation in the incidence of antibiotic resistance among the 0-types. The inherent differences in the ability to achieve significant R-plasmid spread, which appear to be determined by the host, not the plasmid, may be compounded in some cases by the inhibition of potential mating partners by colicin production.The distribution of antibiotic resistance (R) plasmids throughout Escherichia coli populations is not random. A study of E. coli isolated from human feces (9) has demonstrated that strains of 0-antigen types 08, 09, and 0101 occur at a far higher frequency among antibioticresistant isolates (whether shown to carry Rplasmids or not) than among isolates that are antibiotic susceptible. These 0-types are also found to be prevalent among antibiotic-resistant strains isolated from calf feces. A further study has shown that a difference also exists between the 0-types common among the antibiotic-susceptible and -resistant populations of E. coli causing urinary tract infections; 0-types 04, 08, 09, 017, and 018 occur at a relatively high frequency in the R-plasmid-bearing group (16).The majority of urinary tract infections are caused by the predominant 0-type in the patient's own feces at the time of infection (7, 18), but the proportion of infections caused by antibiotic-resistant strains could be affected by such factors as relative colonization and survival ability in the urinary tract and chemotherapeutic practice. Among the various 0-types, colonization and survival ability might be affected to differing degrees by the carriage of R-plasmids.Whether R-plasmid distribution among urinary tract E. coli is indeed determined by such t

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Serum Bactericidal Activity in Patients with Upper and Lower Urinary Tract Infections

Cited by 40 publications

References 13 publications

Escherichia coliin extra-intestinal infections

Escherichia coliin extra-intestinal infections

The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

Spread of R-plasmids among Escherichia coli causing urinary tract infections

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