The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

Marsh, Frank; Banerjee, Rupak K.; Panchamia, P.

doi:10.1136/jcp.27.4.297

Cited by 23 publications

(10 citation statements)

References 21 publications

(21 reference statements)

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“…We have previously demonstrated a strong correlation between the degree of subepithelial lymphocytic infiltration in the bladder and the occurrence of urinary infection (Marsh et al, 1974). The apparent lack of correlation between infection and squamous change was supported by a similar lack of correlation between squamous change and the subepithelial lymphocytic grading (table III); this was so whether all subjects or only females were considered and was irrespective of the site of biopsy.…”

Section: Squamous Change and Site Of Biopsymentioning

confidence: 68%

“…The finding of squamous change was compared with symptoms present in patients at the time of biopsy, and the frequency of symptoms during the prebiopsy observation period, in the manner previously described (Marsh et al, 1974).…”

Section: Squamous Change and Symptomsmentioning

confidence: 99%

“…Details of patients and controls, and our bacteriological and statistical methods, have been given elsewhere (Marsh, Banerjee, and Panchamia, 1974).…”

mentioning

confidence: 99%

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The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

1974

J Clin Pathol

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The occurrence of squamous change in the bladder epithelium was studied in bladder biopsies from patients with recurrent urinary infections or symptoms of cystitis and comparisons were made with sections taken at necropsy from control subjects. Two types of squamous change, termed `vaginal' and `cornified', are described. Vaginal change was frequent in females, and seemed to be a normal finding in them, but was not observed in males. It did not seem to be caused by urinary infection. Cornified change was also common in females and was found in one (infected) man. Like vaginal change it was most often found in sections from the trigone. Urinary infection may predispose to its formation but we were unable to prove this. Squamous change did not seem to cause symptoms, and could not usually be recognized at cystoscopy. The varieties described are so common that they are unlikely to be markedly precarcinomatous.

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Section: Squamous Change and Site Of Biopsymentioning

confidence: 68%

Section: Squamous Change and Symptomsmentioning

confidence: 99%

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The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

1974

J Clin Pathol

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“…Light microscopy appeared to be a poor guide to the presence of infection as only half of the 10 group L3 cases had evidence of present infection (group B3 or currently positive MSU), the other five having had infections within the previous three months. These results can be compared with those reported by Marsh, Banerjee, and Panchamia (1974) who used a different system of histological grading and investigated a larger series of cases. They found that definite focal or diffuse lymphocytic infiltration and germinal follicle formation correlated significantly with infection.…”

Section: Discussionmentioning

confidence: 87%

An ultrastructural study of the urinary bladder in children correlated with histological, bacteriological, and clinical findings.

Haynes¹,

Trott²,

Islam³

et al. 1975

J Clin Pathol

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SYNOPSIS Bladder biopsies from six boys without a history of urinary tract infection were taken during hypospadias repair operations and examined by electron microscopy. The ultrastructure of the epithelium, which was presumed to represent the normal, is described in detail and compared with the reported findings in other mammalian species. The appearances are generally similar although in our material the luminal membrane of the superficial cells was thicker than that surrounding the other epithelial cells but not asymmetrical. We observed membrane-coating granules which have not been reported before in bladder epithelium.The appearances of the normal bladder are compared to those seen in 24 children with urinary infection. In the presence of acute infection the large heterogeneous secondary lysosomes which are present in the intermediate and superficial cells of the normal bladder are reduced in number and the amount of rough endoplasmic reticulum is increased.The electron microscopic appearances of the urinary bladder epithelium of several mammalian species are well documented but there are few reports of similar studies in man. Fulker, Cooper, and Tanaka (1971) described the ultrastructure of human transitional cell carcinoma and commented on the appearance of the epithelium in the non-neoplastic areas, and Battifora, Eisenstein, and McDonald (1964) Materials and Methods CLINICALSpecimens of bladder mucosa were obtained from the trigone at the time of suprapubic urinary diversion in six boys aged 2-13 years (table I)

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“…With repeat bouts of UTI and chronicity of the disease, there is formation of lymphoid tissue follicles, particularly in the lamina propria of the trigonal region, identified as cystitis follicularis or follicular cystitis. [1][2][3] Contributing to the development of the entity are pathologic anatomic or physiologic factors, which induce and prolong the UTI, such as bladder outlet obstruction, neurogenic or muscular dysfunction of the bladder or the urethra, or relaxation of the pelvic floor, to mention a few. 4 In childhood chronic UTI, resulting from bladder outlet or urethral obstructive disease, or ureteral reflux, there is frequently associated cystitis follicularis, accompanied in many cases by cystitis cystica.…”

Section: Discussionmentioning

confidence: 99%

Cytologic manifestations of cystitis follicularis in urine specimens

Zaharopoulos

2002

Diagnostic Cytopathology

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Four cases of cystitis follicularis diagnosed by urine cytology are presented, and are the first reported in the cytologic literature. Cystitis follicularis (follicular cystitis) is characterized by formation of lymphoid follicles in the lamina propria of the trigonal region of the bladder, and is considered to be the result of repeated bouts of urinary tract infection, usually bacterial, with other pathologic processes contributing to the development and prolongation of the infection. Cytologically it differs from chronic cystitis with prominent lymphocytosis by the presence of cellular elements from the germinal centers of lymphoid follicles, reminiscent of the cytologic findings in follicular cervicitis, with possible additional epithelial cytologic atypias from the overlying urothelium, which frequently undergoes reactive changes (hyperplastic, metaplastic, and ulcerative). The practical aspect of recognition of this entity in cytologic specimens is avoiding diagnostic errors of possible malignancy (lymphoid or other), and also of other forms of inflammatory disease, such as granulomatous type, with a different clinical significance.

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The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

Abstract: PATIENTSFifty bladder biopsies were taken, after full explanation and discussion, from 37 female and four male patients suspected or known to have urinary infections. Thirty-one patients had recurrent cystitis, five painless frequency, and one abdominal pain.

Cited by 23 publications

References 21 publications

The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

The relationship between urinary infection, cystoscopic appearance, and pathology of the bladder in man

An ultrastructural study of the urinary bladder in children correlated with histological, bacteriological, and clinical findings.

Cytologic manifestations of cystitis follicularis in urine specimens

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