2001
DOI: 10.1007/s001470100009
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Serum bile acids in liver transplantation - early indicator for acute rejection and monitor for antirejection therapy

Abstract: We studied the course of serum bile acids to investigate its reliability in the diagnosis of acute rejection after liver transplantation in relation to pathohistological findings. Serum bile acid concentration, bilirubin and transaminases were measured in 41 patients who underwent liver transplantation. Their course was correlated to liver biopsy. Group I (n = 19) patients were without acute rejection, whereas group II (n = 22) patients showed acute rejection. Bile acid concentrations in group II showed a stat… Show more

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Cited by 12 publications
(15 citation statements)
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“…A complete hepatic check-up was performed, and serum bile salts were also measured ( Supplementary Tables 3-5 for clinical data). We found that patients who had a high potential of acute cellular rejection (ACR) after liver transplantation (serum bile acid > 37 μM) 53 had significant and visible colorimetric signal changes ( Supplementary Fig. 16 ) in bactosensor assays.…”
Section: Resultsmentioning
confidence: 99%
“…A complete hepatic check-up was performed, and serum bile salts were also measured ( Supplementary Tables 3-5 for clinical data). We found that patients who had a high potential of acute cellular rejection (ACR) after liver transplantation (serum bile acid > 37 μM) 53 had significant and visible colorimetric signal changes ( Supplementary Fig. 16 ) in bactosensor assays.…”
Section: Resultsmentioning
confidence: 99%
“…A complete hepatic check-up was performed, and serum bile salts were also measured (Supplementary Tables 3-5 for clinical data). We found that patients who had a high potential of acute cellular rejection (ACR) after liver transplantation (serum bile acid > 37 µM) 53 had signi cant and visible colorimetric signal changes (Supplementary Fig. 16) in bactosensor assays.…”
Section: Development Of a Colorimetric Version Of The Bactosensormentioning
confidence: 98%
“…For determination of DAO and HNMT activities, frozen small bowel samples of 100-300 mg were thawed on ice and then homogenised, in an Ultra-Turrax T25 homogeniser (Janke and Kunkel, Staufen, Germany) with an S25N-8G probe, at 10 …”
Section: Biochemical Analysismentioning
confidence: 99%