Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis

Torres, Joana; Petralia, Francesca; Sato, Takahiro; Wang, Pei; Telesco, Shannon; Choung, Rok Seon; Strauß, Richard; Li, Xiao Jun; Laird, Renée M.; Gutiérrez, Ramiro L.; Porter, Chad K.; Plevy, Scott E.; Princen, Fred; Murray, Joseph A.; Riddle, Mark S.; Colombel, Jean Fréd́eric

doi:10.1053/j.gastro.2020.03.007

Cited by 159 publications

(161 citation statements)

References 28 publications

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“…In accord with our previous study [51], for currently unclear reasons, ASCA levels were generally higher in the IgG class than the IgA class. By contrast, IgA class ASCA seems to be more consistently elevated in IBD [48,52]. Which of these two antibody classes is the more useful marker in CD would be an interesting subject for further research.…”

Section: Discussionmentioning

confidence: 95%

“…We previously found most of the potential CD patients to already exhibit the microbial markers before the development of villous damage or autoantibodies [21], reflecting the situation in the relatives in the present study. Interestingly, Torres and colleagues recently showed that ASCA also predicts forthcoming Crohn's disease up to five years before the diagnosis [48]. More studies are needed to determine the role of these markers in early development of CD and whether they could be utilized to predict the disease in at-risk groups.…”

Section: Discussionmentioning

confidence: 99%

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First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

et al. 2020

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Risk of celiac disease (CD) is increased in relatives of CD patients due to genetic and possible environmental factors. We recently reported increased seropositivity to anti-Saccharomyces cerevisiae (ASCA), Pseudomonas fluorescens-associated sequence (anti-I2) and Bacteroides caccae TonB-linked outer membrane protein (anti-OmpW) antibodies in CD. We hypothesized these markers also to be overrepresented in relatives. Seropositivity and levels of ASCA, anti-I2 and anti-OmpW were compared between 463 first-degree relatives, 58 untreated and 55 treated CD patients, and 80 controls. CD-associated human leukocyte antigen (HLA)-haplotypes and transglutaminase (tTGab) and endomysium (EmA) antibodies were determined. One or more of the microbial antibodies was present in 75% of relatives, 97% of untreated and 87% of treated CD patients and 44% of the controls. The relatives had higher median ASCA IgA (9.13 vs. 4.50 U/mL, p < 0.001), ASCA IgG (8.91 vs. 5.75 U/mL, p < 0.001) and anti-I2 (absorbance 0.74 vs. 0.32, p < 0.001) levels than controls. There was a weak, positive correlation between tTGab and ASCA (r = 0.31, p < 0.001). Seropositivity was not significantly associated with HLA. To conclude, seropositivity to microbial markers was more common and ASCA and anti-I2 levels higher in relatives of CD patients than controls. These findings were not associated with HLA, suggesting the role of other genetic and environmental factors.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

et al. 2020

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“…Previous clinical data showed that co‐existence of H pylori with Candida is associated with the development of gastric ulcers, proposing potential synergism of these microorganisms in initiating digestive diseases 74 . Anti‐ Saccharomyces cerevisiae antibodies (ASCA) have been proved predictive of Crohn's disease (CD) 75 . Interestingly, researchers found an inverse relationship between H pylori infection and the presence of ASCA 76 .…”

Section: Future Directionsmentioning

confidence: 99%

Helicobacter pylori infection and eradication: Exploring their impacts on the gastrointestinal microbiota

2020

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The rapid development of microbiota research has remolded our view of human physiological and pathological processes. Among all the gastrointestinal microorganisms, Helicobacter pylori (H pylori) is probably the most notorious constituent. Although half of the adults worldwide are infected with H pylori, their clinical manifestations vary widely, suggesting other microorganisms beyond H pylori may play a role in determining clinical outcomes. Recently, many studies have put effort into elucidating the crosstalk within the human microbiota, some of which specifically explored the interplay between H pylori and other gastrointestinal microbial members. In this work, we reviewed these potential interactions. Meanwhile, the impacts of H pylori eradication therapy on gastrointestinal microbial homeostasis were summarized in terms of diversity, composition, functional capacity, and antibiotic resistance.

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“…It is on this complex background that 2 studies published in Gastroenterology this month point us in different directions along the etiologic and diagnostic hunt. 3,4 In the article by Nair et al, 3 the authors relate the presence of heavy metals in baby teeth to the later development of Crohn's disease. They lead off their discussion by suggesting that this finding is a key link to urbanization associated with Crohn's disease.…”

mentioning

confidence: 99%

“…In the study by Torres et al, 4 a serum bank of Department of Defense recruits was accessed to study for microbial antibodies and immune-inflammatory markers for 5 years antedating diagnoses of either Crohn's disease or ulcerative colitis. Anti-Flagellin X and ASCA-IgA were predictive of Crohn's disease.…”

mentioning

confidence: 99%

New Biomarkers for Crohn’s Disease

Bernstein

2020

Gastroenterology

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Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis

Cited by 159 publications

References 28 publications

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

Helicobacter pylori infection and eradication: Exploring their impacts on the gastrointestinal microbiota

New Biomarkers for Crohn’s Disease

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