Serum Bone-Gla Protein After Fracture

Obrant, Karl; Merle, Blandine; Béjui, J.; Delmas, Pierre D.

doi:10.1097/00003086-199009000-00035

Cited by 41 publications

(21 citation statements)

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“…Levels of bone resorption markers in the delayed union group did not differ from those in the normally united group for patients with tibial shaft fractures. However, levels of bone formation markers, including osteocalcin, Type I collagen C-terminal propeptide, and bone-specific alkaline phosphatase, were lower in the delayed union group than in the normally united group [16,20]. These results in previous studies were in good agreement with our results.…”

Section: Discussionsupporting

confidence: 93%

“…Changes in bone resorption and formation markers in the case of nonunion of long bones have been reported [8,15,16,19,20,22]. Levels of bone resorption markers in the delayed union group did not differ from those in the normally united group for patients with tibial shaft fractures.…”

Section: Discussionmentioning

confidence: 82%

“…Bone resorption markers increased soon after a fracture event and bone formation markers increased gradually thereafter. Also, changes in bone resorption and bone formation markers for patients with nonunion of long bones have been reported [8,15,16,19,20,22]. However, little is known regarding the changes in bone metabolism in the case of delayed or nonunion of the spine.…”

Section: Introductionmentioning

confidence: 99%

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Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Ohishi

Takahashi

Yamanashi

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Time-dependent changes in bone markers in delayed or nonunion of vertebral fracture were compared with those of normal union. Thirty-three patients with a fresh vertebral fracture were enrolled. Urinary Type I collagen C-terminal telopeptide, pyridinoline, deoxypyridinoline, serum C-terminal telopeptide, and N-midportion of osteocalcin (OC N-mid ) were determined at the time of hospital admission (within 24 hours after the fracture event in all cases) and at 2, 4, 12, 24, and 48 weeks thereafter.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Ohishi

Takahashi

Yamanashi

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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“…2). After this stage, a significant increase in bone formation markers has been demonstrated -that of the enzyme BALP and OC, since they were derived from osteoblast synthesis, produced during bone ECM mineralization and osteoblast maturation respectively (Obrant et al 1990, Bowles et al 1996, Laurer et al 2000, of type-I collagen products (Veitch et al 2006, Stoffel et al 2007, and the persistence of high PIIINP levels, which are released during the formation as well as during the degradation of the fibrous tissue (Joerring et al 1992(Joerring et al , 1994 (Fig. 2).…”

Section: Discussionmentioning

confidence: 97%

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Sousa

Dias

López-Peña

et al. 2015

An. Acad. Bras. Ciênc.

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Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.

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“…Together with the fact that high bone turnover may be sustained for long periods and bone loss may increase with age (44), these findings may provide a rationale for designing more effective intervention strategies. However, other factors such as age (see above), medication (6,18,(46)(47)(48)(49)(50)(51), immobilisation (32,35), thyroid function (52), co-morbidity (35) and the fracture itself (40,53,54) do influence bone metabolism and therefore need to be considered in the interpretation of biochemical data and their use in individual patients. Clearly, none of the biochemical markers of bone turnover has proven useful as a single diagnostic index of osteoporosis.…”

Section: Bone Turnover In Osteoporosismentioning

confidence: 99%

Clinical application of biochemical markers of bone turnover

Seibel

2006

Arq Bras Endocrinol Metab

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With the ageing population in most countries, disorders of bone and mineral metabolism are becoming increasingly relevant to every day clinical practice. Consequently, the interest in, and the need for effective measures to be used in the screening, diagnosis and follow-up of such pathologies have markedly grown. Together with clinical and imaging techniques, biochemical tests play an important role in the assessment and differential diagnosis of metabolic bone disease. In recent years, the isolation and characterisation of cellular and extracellular components of the skeletal matrix have resulted in the development of molecular markers that are considered to reflect either bone formation or bone resorption. These biochemical indices are non-invasive, comparatively inexpensive and, when applied and interpreted correctly, helpful tools in the diagnostic and therapeutic assessment of metabolic bone disease. This review provides an overview of the current evidence regarding the clinical use of biochemical markers of bone remodelling in bone disease, with an emphasis on osteoporosis. RESUMO Marcadores Bioquímicos da Remodelação Óssea.Tendo em vista o crescimento da população idosa na maioria dos paí-ses, os distúrbios do metabolismo ósseo e mineral estão tornando-se cada vez mais relevantes na prática clínica diária. Conseqüentemente, o interesse e a necessidade de medidas efetivas para serem usadas no rastreamento, diagnóstico e seguimento de tais patologias vêm crescendo acentuadamente. Além da avaliação clínica e de técnicas de imagens, os marcadores bioquímicos desempenham um importante papel na avaliação e diagnóstico das doenças ósseas metabólicas. Recentemente, a melhor caracterização dos componentes intracelulares e extracelulares da matriz óssea resultou no desenvolvimento dos marcadores moleculares, os quais refletem tanto a formação como a reabsorção óssea. Estes marcadores bioquímicos não são invasivos e comparativamente são de mais baixo custo, e quando aplicados e interpretados corretamente são instrumentos úteis no diagnóstico e tratamento das doenças ósseas metabólicas. Esta revisão abordará evidências atuais, levando em consideração o uso clínico dos marcadores bioquímicos da remodelação óssea nas doenças metabólicas ósseas, com ênfase na osteoporose.

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Serum Bone-Gla Protein After Fracture

Cited by 41 publications

References 0 publications

Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine

Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Clinical application of biochemical markers of bone turnover

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