Serum butyrylcholinesterase activity and phenotype associations with lipid profile in stroke patients

Vaisi‐Raygani, Asad; Tavilani, Heidar; Zahrai, Mahine; Rahimi, Zohreh; Sheikh, Nasrin; Aminian, Mahdi; Pourmotabbed, Tayebeh

doi:10.1016/j.clinbiochem.2008.10.025

Cited by 20 publications

(17 citation statements)

References 33 publications

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“…The negative associations between TC levels with number of oocytes, cleavage embryos, normal fertilized oocytes, and good quality embryos of women were consistent with previous studies [18,19]. Some observations regarding the development of human follicle suggest governing in vitro human embryo fragmentation may depend on the cholesterol metabolism, while the processes that regulating embryo cell division rate may be independent of the cholesterol metabolism [20]. We suggest further studies at the molecular and cellular level.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles

Nikbakht

Mohammadjafari

Rajabalipour

et al. 2021

Fertil Res and Pract

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Background To evaluate factors affecting oocyte/embryo quality in PolyCystic Ovary Syndrome (PCOS) patients undergoing Assisted Reproductive Technology (ART) cycles. Methods This case-control retrospective study was performed on PCOS patients referred to the infertility department of Imam Khomeini Hospital in Ahvaz from October 2017 to September 2019. Demographic and reproductive characterizations including age, gender, abortion history and infertility type (primary and secondary infertility) were extracted from patient’s records. TSH, AMH, LH, FSH, prolactin, lipid profile and blood glucose was measured. Biochemistry pregnancy was checked by determination of serum βHCG level and then, clinical pregnancy was confirmed by observing of pregnancy sac and fetal heart rate using Transvaginal USS. Results One-hundred thirty-five patients include 45 PCOS and 90 Non-PCOS patients with mean age of 31.93 ± 5.04 and 30.8 ± 5.38 (p = 0.24) were considered as case and control groups respectively. Retrieved oocyte numbers were significantly higher in PCOS patients (p = 0.024), but there was no significant difference in number of oocyte subtypes (MI, MII and GV) between two groups. The embryo numbers and its subtypes did not differ significantly in both groups. The clinical pregnancy rate was insignificantly lower in PCOS patients (p = 0.066) and there was a significant correlation between retrieved oocyte numbers with age(r= -0.2, p= 0.022) and AMH level (r = 0.433, p < 0.0001) respectively. Cholesterol level had shown a positive significant correlation with number of MI oocytes (r = 0.421, p = 0.026) and MII oocytes significantly affected by age (r= -0.250, p = 0.004) and AMH level (r = 0.480, p < 0.0001). Using Receiver operation characteristic (ROC) curve analysis, the cut-off value of total number of oocytes was > 10.5 with area under curve of 0.619±0.054(sensitivity 55.56% and specificity 69.66%) Conclusions The results of this study showed that although the number of oocytes in PCOS patients was significantly higher than non-PCOS patients, the quality of oocytes was not statistically different. The number and quality of embryos were not significantly different in both groups. Our results indicated a significant relationship between the level of AMH and the number of retrieved oocytes and embryos. We found there is a significant correlation between cholesterol level and number of MI oocytes.

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Section: Discussionsupporting

confidence: 90%

Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles

Nikbakht

Mohammadjafari

Rajabalipour

et al. 2021

Fertil Res and Pract

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“…our results thus suggest that the effect of the 1615G➝a (ala539Thr) polymorphism of BCHE on ischemic stroke is not attributable to its effect on blood pressure. a recent study (34) showed that serum bcHe activity was lower in subjects with ischemic stroke than in controls, supporting our observation. However, the molecular mechanism underlying the association of the 1615G➝a (ala539Thr) polymorphism of BCHE with ischemic stroke remains to be elucidated.…”

Section: Discussionsupporting

confidence: 82%

Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease

Oguri¹,

Kato²,

Yokoi³

et al. 2009

Mol Med Rep

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Abstract. although chronic kidney disease (cKd) is an important risk factor for ischemic stroke, the genetic variants that confer susceptibility to ischemic stroke in individuals with cKd remain largely unknown. We performed an association study for candidate gene polymorphisms and ischemic stroke in individuals with cKd. The study population comprised 1041 Japanese individuals with cKd, including 228 subjects with ischemic stroke and 813 controls. The genotypes of 150 polymorphisms of 127 candidate genes were determined by a method that combines polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. an initial ¯2 test (false discovery rate <0.05) and subsequent multivariate logistic regression analysis with adjustment for covariates (P<0.05) revealed that the 1615G➝a (ala539Thr) polymorphism (rs1803274) of BCHE (or=3.33; 95% ci 1. 32-8.28) and the 2445G➝a (ala54Thr) polymorphism (rs1799883) of FABP2 (or=1.66; 95% ci 1.01-2.70) were significantly associated with ischemic stroke. The variant alleles of BCHE and FABP2 were risk factors for ischemic stroke. a stepwise forward selection procedure demonstrated that the BCHE genotype was a significant (P<0.05) and independent determinant of ischemic stroke. Genotyping for BCHE may prove informative for the assessment of the genetic risk of ischemic stroke in Japanese individuals with cKd.

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“…Some of these (the atypical, the silent and the fluoride-resistant variants) are well known because carriers are prone to develop prolonged apnea following the administration of the muscle relaxant succinylcholine. [15][16][17] The association between BuChE activity with lipid and lipoprotein levels, type 2 diabetes mellitus (T2DM), stroke and CVD is well studied. 9,[11][12][13][14][15][16][17][18][19][20] We recently observed that the frequency of BuChE non-UU phenotypes (low activity) was high in stroke patients, who had high levels of cholesterol that might increase susceptibility to stroke.…”

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confidence: 99%

Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report

Bahrehmand

Vaisi‐Raygani

Rahimi

et al. 2014

Lupus

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There is some evidence indicating lipid peroxidation can affect progression of atherosclerosis, cardiovascular diseases (CVDs) and glomerulonephritis in systemic lupus erythematosus (SLE) patients. Human butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are two major bioscavenger enzymes that are associated with inflammation, oxidative stress and lipid metabolism. Hyperlipidemia, increase in lipid oxidation reactions and defects in antioxidant status may lead to increased oxidative stress and high frequency of CVDs in SLE. It has also been suggested that deficiency in the function of the antioxidant system and an increase in reactive oxygen release (ROS) may play an important role in the pathogenesis of SLE. This study is the first investigation to examine the association of BuChE phenotypes, PON1 (L55M; PON-55-M) polymorphism, the levels of malondialdehyde (MDA), neopterin, lipid-lipoprotein and activities of BuChE and arylesterase activity (ARE) of PON with severity of SLE. The present case-control study consisted of 109 SLE patients and 101 gender- and age-matched, unrelated healthy control subjects from the population of west Iran. We found that the PON-55-M allele and BuChE non-UU act synergistically to increase the risk of SLE by 2.5 times (1.03-6.7, p = 0.044). There was a significant negative correlation between severity of SLE with serum BuChE activity (R = -0.31, p < 0.001) and positive correlation with serum neopterin level. The SLE patients with the PON-55-M (M/L + M/M) allele or with BuChE non-UU phenotype had significantly lower serum ARE and BuChE activities than those with PON-55-L/L or BuChE-UU phenotypes, respectively. In addition, their serum levels of MDA, neopterin and LDL-C were significantly elevated, suggesting that these individuals are more susceptible to CVD. However, further studies are needed to shed more light on the contribution of the M allele of PON1 and non-UU phenotypes of BuChE in the development of SLE in different ethnicities.

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Serum butyrylcholinesterase activity and phenotype associations with lipid profile in stroke patients

Cited by 20 publications

References 33 publications

Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles

Evaluation of oocyte quality in Polycystic ovary syndrome patients undergoing ART cycles

Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease

Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report

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