Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report

Bahrehmand, Fariborz; Vaisi‐Raygani, Asad; Rahimi, Zohreh; Ahmadi, Reza; Kiani, Amir; Tavilani, Heidar; Vaisi-Raygani, H.; Pourmotabbed, Tayebeh

doi:10.1177/0961203313518622

Cited by 25 publications

(20 citation statements)

References 32 publications

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“…Our results are in agreement with other studies demonstrating that decrease of human BChE activity is associated with oxidative stress [26, 54]. Tagliari et al found that an increase in oxidative stress was associated with inhibition of BChE and an increase in homocysteine levels in blood of rats [21].…”

Section: Discussionsupporting

confidence: 93%

“…Disruption of the pro- and anti-oxidative equilibrium may cause an increased pulmonary inflammatory reaction, leading to elevated expression of tumor necrosis factor (TNF-α), interleukin (IL)-6, IL-8, and IL-1β, which are used as diagnostic markers in that disease [24, 25]. Human BChE and paraoxonase-1 are two major bioscavenger enzymes that are associated with inflammation, oxidative stress and lipid metabolism [26]. Moreover, due to its properties, BChE participates in the metabolism of numerous xenobiotics [27–29] and drugs, including those used for COPD treatment, such as aclidinium bromide [30].…”

Section: Introductionmentioning

confidence: 99%

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Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

Sicińska

Bukowska

Pająk

et al. 2017

aoms

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IntroductionButyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids. Butyrylcholinesterase activity is associated with both inflammation and oxidative stress. Changes in the activity of this enzyme have been observed in various diseases such as liver cirrhosis, diabetes, neurodegenerative disease and others.Material and methodsThe study involved 30 patients with chronic obstructive pulmonary disease (COPD) and 18 healthy subjects. The COPD patients were divided according to the severity of the disease by applying the classification of COPD based on GOLD standards for forced expiratory volume in 1 s (FEV1) and the FEV1/forced expiratory volume (FVC) ratio. The control group comprised blood samples collected from healthy subjects without concomitant diseases related to the respiratory system. Butyrylcholinesterase activity, lipid peroxidation and total antioxidant capacity (TAC) were determined in the blood plasma.ResultsA significant (p < 0.05) decrease in the activity of BChE, associated with an increase in lipid peroxidation and a decrease in the total antioxidant capacity, was observed in blood plasma of patients with chronic obstructive pulmonary disease.ConclusionsThe study shows for the first time that activity of BChE in the blood plasma of patients diagnosed with chronic obstructive pulmonary disease is considerably reduced compared with healthy subjects. These changes were accompanied by a decrease of TAC and an increase of lipid peroxidation, which suggests that they may be related to the oxidative stress induced by COPD disease.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

Sicińska

Bukowska

Pająk

et al. 2017

aoms

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“…49, 50 Increased oxidative stress has been described in patients with type 1 diabetes as well, which could also result in accelerated progression of atherosclerosis. 51 In this study, HDL from SLE patients with subclinical atherosclerosis (as determined by carotid plaque) possessed increased pro-inflammatory activity in vitro , which was accompanied by depletion of PON3.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase-3 Is Depleted from the High-Density Lipoproteins of Autoimmune Disease Patients with Subclinical Atherosclerosis

Marsillach¹,

Becker²,

Vaisar³

et al. 2015

J. Proteome Res.

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Patients with autoimmune diseases have a significantly increased risk of developing cardiovascular disease. In disease, high density lipoprotein (HDL) particles lose their anti-inflammatory and antioxidant properties, becoming dysfunctional. The purpose of this study was to test the hypothesis that alterations in the HDL proteomic profile are associated with subclinical atherosclerosis and HDL dysfunction in patients with autoimmune diseases such as systemic lupus erythematosus (SLE) and type 1 diabetes. Targeted proteomics was used to quantify the relative abundance of 18 proteins in HDL from SLE patients with and without atherosclerotic plaque detectable by carotid ultrasound. Changes in the proteomic profile were compared against the in vitro ability of HDL to protect against lipid oxidation. The same proteins were quantified in HDL from patients with type 1 diabetes with or without coronary artery calcification as determined by computed tomography. In each population, paraoxonase-3 (PON3), a potent antioxidant protein, was depleted from the HDL of patients with subclinical atherosclerosis. PON3 expression in HDL was positively correlated with HDL antioxidant function. These results suggest that PON3 may be an important protein in preventing atherosclerosis and highlights the importance of antioxidant proteins in the prevention of atherosclerosis in vivo.

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“…In addition, PON1 is a 43–45 kDa glycoprotein, synthesized in the liver and secreted in blood [5,6]. PON1 is associated with coronary artery disease, stroke, Alzheimer’s disease, chronic renal failure, metabolic syndrome, chronic liver impairment [7–10], and dermatosis such as psoriasis and systemic lupus erythematosus (SLE) [11,12]. In addition to the aforementioned diseases, PON1 is also involved in ageing and longevity [13,14].…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population

et al. 2016

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BackgroundThe present study was performed to identify the association of PON1 rs662 polymorphism with serum lipid levels and human longevity in the Bama Zhuang population.Material/MethodsPON1 genotypes were determined by Taqman SNP Genotyping Assays in 110 long-lived inhabitants (longevity group, aged 90–110 years), 110 healthy inhabitants in Bama County (control 1 group, aged 43–82 years) and 110 healthy inhabitants in Nandan County (control 2 group, aged 28–82 years) without family history of longevity.ResultsBMI (body mass index) and TG (serum total triglyceride) level were lower in the longevity group than in the two control groups, while the contents of serum LDL-c (low-density lipoprotein cholesterol) and HDL-c (high-density lipoprotein cholesterol) and the levels of SBP (systolic blood pressure) and DBP (diastolic blood pressure) in the longevity group were higher than in the two control groups (p<0.01). Significant differences in the frequencies of three genotypes (GG, AG, and AA) were observed between the longevity group and control 2 group (χ2=15.190, p=0.001). The minor allele frequency (MAF) of rs662 was significantly higher in the longevity group than in the two control groups. The levels of HDL-c in the longevity group were different among the three genotypes (p<0.05). The levels of TG for GG and GG+AG genotypes were significantly different, while the levels of TC (total cholesterol) and HDL-c for AG and GG+AG genotypes were significantly different among the three groups (p<0.05). Serum lipid parameters were correlated with several environmental factors, including age, gender, DBP, SBP, and BMI. The association of PON1 rs662 polymorphism and serum lipid levels was different among the three groups.ConclusionsPON1 polymorphism might be one of the genetic factors of longevity in the Bama Zhuang population. The PON1 rs662 SNP (single nucleotide polymorphism) was associated with serum HDL-c levels in the longevity group.

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Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report

Cited by 25 publications

References 32 publications

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

Paraoxonase-3 Is Depleted from the High-Density Lipoproteins of Autoimmune Disease Patients with Subclinical Atherosclerosis

Paraoxonase-1 (PON1) rs662 Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Zhuang Population

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