Serum C‐reactive protein in pediatric kidney and liver transplant patients

Their, Maria; Rönnholm, Kai; Sairanen, Heikki; Holmberg, Christer; Jalanko, Hannu

doi:10.1034/j.1399-3046.2002.01071.x

Cited by 28 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…infection [32,33]. C-RP has been considered a sensitive, but not specific, marker for graft-related complications after organ allotransplantation in humans [34,35]. Notably, C-RP can also promote TF expression [36].…”

Section: C-reactive Protein (C-rp) In Xenograft Recipientsmentioning

confidence: 99%

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

Ezzelarab

Cooper

2015

International Journal of Surgery

View full text Add to dashboard Cite

Inflammation is a complex response that involves interactions between multiple proteins in the human body. The interaction between inflammation and coagulation is well-recognized, but its role in the dysregulation of coagulation in xenograft recipients is not well-understood. Additionally, inflammation is known to prevent the development of T cell tolerance after transplantation. Recent evidence indicates that systemic inflammation precedes and may be promoting activation of coagulation after pig-to-primate xenotransplantation. Activated recipient innate immune cells expressing tissue factor are increased after xenotransplantation, irrespective of immunosuppressive therapy. With immunosuppression, C-reactive protein (C-RP), fibrinogen, and interleukin-6 levels are significantly increased in pig artery patch recipients. In pig organ recipients, increased C-RP levels are observed prior to the development of features of consumptive coagulopathy. Systemic inflammation in xenograft recipients (SIXR) may be a key factor in the development of dysregulation of coagulation, as well as in resistance to immunosuppressive therapy. While genetic modification of the donor pigs provides protection against humoral responses and the development of thrombotic microangiopathy, therapeutic prevention of SIXR may be essential in order to prevent systemic dysregulation of coagulation in xenograft recipients without the use of intensive immunosuppression.

show abstract

Section: C-reactive Protein (C-rp) In Xenograft Recipientsmentioning

confidence: 99%

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

Ezzelarab

Cooper

2015

International Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…CRP is also useful for managing neonatal septicemia and for identifying organ rejection in renal transplant recipients (31). CRP can be elevated in noninflammatory states, such as obesity (12,36,47), sleep disturbances (34), depression (1), chronic fatigue (2), aging (15), physical inactivity (29), and radiotherapy (4), and in persons who smoke (28,33).…”

mentioning

confidence: 99%

Analytical Performance of a Highly Sensitive C-Reactive Protein-Based Immunoassay and the Effects of Laboratory Variables on Levels of Protein in Blood

Aziz

Fahey

Detels

et al. 2003

Clin Vaccine Immunol

107

View full text Add to dashboard Cite

C-reactive protein (CRP) is an acute-phase reactant whose levels increase in response to a variety of inflammatory stimuli. Elevated levels in serum are observed after trauma, tissue necrosis, infection, surgery, and myocardial infarction and are associated with an increased risk of cardiovascular disease. CRP levels are also elevated in noninflammatory states, such as obesity, sleep disturbances, depression, chronic fatigue, aging, and physical inactivity. In this study, the performance of a highly sensitive CRP enzyme immunoassay was evaluated, along with common laboratory variables (specimen type, processing time, and storage conditions) that may influence measured blood concentrations of CRP. The measurement range of the assay was from 0.4 to 50 g/liter. Total imprecision (coefficient of variation) ranged from 8.1 to 11.4%. CRP levels obtained with the enzyme immunoassay were highly correlated with those obtained with an automated immunonephelometric assay. Comparable results were obtained for plasma (heparin and EDTA treated) and serum samples, and levels were unaffected by delays in sample processing and storage temperature. CRP levels were also unaffected by up to seven freeze-thaw cycles. The median CRP concentration in healthy adults was determined to be 0.94 mg/liter, with a 95% working reference interval of 0 to 6.9 mg/liter. In view of these data, we recommend that serial serum or plasma samples for CRP should be stored at 4 o C for short periods of time or at ؊70 o C for longer periods and tested within the same run to minimize interassay variability.

show abstract

“…CRP presents high sensitivity with poor specificity for infectious complication and rejection. (63)(64)(65)(66)(67). Elevated WBC count and low HLA-DR on monocytes are useful parameters for the detection of infectious complications (26,68), but not for the detection of rejection (26,69).…”

Section: Original Articlementioning

confidence: 99%

Increased CD64 expression on polymorphonuclear neutrophils indicates infectious complications following solid organ transplantation

et al. 2011

View full text Add to dashboard Cite

The aim of this study was to evaluate the diagnostic value of monitoring CD64 antigen upregulation on polymorphonuclear neutrophils (PMN) for the identification of infectious complications in the postoperative course of solid organ transplanted patients. Twenty-five kidney, 13 liver, and four pancreas-kidney transplanted patients were included. Beginning with preoperative values up to postoperative values after 3 months for each patient, the PMN CD64 Index, HLA-DR on monocytes, NKp44 1 NK and NK/T cells, CXCR31 NK cells, CXCR3 1 T helper cells, CXCR3 1 NK/T cells, and CD4/ CD8 ratio were measured by flow cytometry. Subsequently they were correlated with confirmed postoperative complications. Measuring the PMN CD64 Index reached a sensitivity of 89% and a specificity of 65% in the detection of infectious complications. Concerning this matter, it was a significantly better marker than all other included parameters except CXCR31 NK/T cells. In contrast, according to our results the PMN CD64 Index has no diagnostic relevance in detection of rejections. The combination of included parameters showed no improved diagnostic value. Due to its high sensitivity and specificity for infectious complications CD64 on PMN could be proven a very good indicator in evaluating suspected infectious complications in the postoperative course of transplanted patients. ' 2011 International Society for Advancement of Cytometry

show abstract

Serum C‐reactive protein in pediatric kidney and liver transplant patients

Cited by 28 publications

References 24 publications

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

Systemic inflammation in xenograft recipients (SIXR): A new paradigm in pig-to-primate xenotransplantation?

Analytical Performance of a Highly Sensitive C-Reactive Protein-Based Immunoassay and the Effects of Laboratory Variables on Levels of Protein in Blood

Increased CD64 expression on polymorphonuclear neutrophils indicates infectious complications following solid organ transplantation

Contact Info

Product

Resources

About