Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis

Zhao, Ping; Yu, Qin; Zhang, Aijie; He, Fang; Xu, Shiping; Liang, Chen

doi:10.1186/s12879-021-06772-7

Cited by 7 publications

(10 citation statements)

References 29 publications

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“…In a 16-article meta-analysis, the ovarian cancer tumor marker CA-125 has shown promise for detection of ATB with a pooled sensitivity of 0.85 (10). This highlights the importance of thinking outside the box, to identify novel biomarkers and the potential of usingbiomarkers associated with other disease conditions to diagnose ATB.…”

Section: Other Potential Markersmentioning

confidence: 99%

Editorial: Immuno-diagnosis of active tuberculosis; are we making progress?

Mayanja‐Kizza

Cardona²,

Chegou³

2023

Front. Immunol.

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Editorial on the Research Topic Immuno-diagnosis of active tuberculosisActive tuberculosis (ATB) diagnosis suffers from several knowledge gaps and challenges, including the need for newer assays with faster turn-around-time (TAT), high sensitivity and specificity, lower costs, and the potential for Point-of-Care (POC) use assays. Towards this goal, we need novel tests that can be used at the population level to screen and/or test high risk populations, including household contacts of sputum positive index patients and persons living with HIV/AIDS. In addition, tests that can be adaptable towards use in treatment follow-up (to predict cure or relapse/reinfection), and as potential surrogate markers of tuberculosis (TB) vaccination are important towards the global control of tuberculosis. A test using blood-based samples would have potential for future studies to "estimate" the mycobacterial load in the body (akin to the HIV viral load test), which would improve the treatment of ATB, and latent tuberculosis infection (LTBI). In addition, immune-based POC tests for ATB diagnosis have the potential for low invasiveness, being user friendly for staff and patients, minimal training needs, greater simplicity, and low cost; making immuno-diagnosis of active tuberculosis a promising approach. To date, a number of studies have been done in both high and low TB endemic settings to diagnose, or even predict, the evolution towards ATB. Much as some studies have shown high sensitivity and specificity (over 85%), there are still many challenges towards the ideal test, and more research needs to be done.

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Section: Other Potential Markersmentioning

confidence: 99%

Editorial: Immuno-diagnosis of active tuberculosis; are we making progress?

Mayanja‐Kizza

Cardona²,

Chegou³

2023

Front. Immunol.

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“…Additionally, a recent systematic review and meta-analysis concluded that CA-125 has a potential role for pulmonary tuberculosis diagnosis but further studies should be conducted. 36 The role of CA-125 in extrapulmonary tuberculosis is still relatively uncertain due to lack of large studies. Chen et al compared 23 peritoneal tuberculosis patients and 47 primary peritoneal cancer on clinical characteristics.…”

Section: Extrapulmonary Tuberculosis and Ca-125mentioning

confidence: 99%

“…[38][39][40] This includes pulmonary cancer, breast cancer, pancreatic cancer, and gastrointestinal cancer. 36 Other conditions may include pregnancy, pelvic inflammatory disease, uterine myoma, endometriosis, liver cirrhosis, and heart failure. 40 Patients with benign or malignant pleural effusions can also have elevated CA-125 levels.…”

Section: Extrapulmonary Tuberculosis and Ca-125mentioning

confidence: 99%

Abdominal Tuberculosis Mimicking Ovarian Cancer: A Case Report and Review of the Literature

Rinaldi¹,

Muthalib²,

Gosal³

et al. 2022

IMCRJ

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Tuberculosis (TB) is a disease with high morbidity and mortality resulting from infection by Mycobacterium tuberculosis. TB can disseminate to any organ system of the body resulting in extrapulmonary tuberculosis. Interestingly, CA-125, which is a biomarker for some cancer, also rises in benign diseases such as pulmonary and extrapulmonary tuberculosis which may complicate diagnosis. In this case report, we present an abdominal tuberculosis patient that was initially presented as ovarian cancer. Case Report: A 30-year-old woman admitted to the emergency department with chief complaint of fatigue and shortness of breath since 3 months ago. She had lost around 20 kg weight in the past 5 months. She was previously suspected with ovarian cancer because of the characteristic features of malignancy, high levels of CA-125, and positive PET scan. She was later diagnosed with abdominal TB. Subsequently, the patient was given anti-TB drugs, and the patient showed clinical improvement. Conclusion:In the case of an elevated CA-125, clinicians should consider extrapulmonary TB as a differential diagnosis of ovarian cancer, especially in countries with high burden of tuberculosis.

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“…However, other authors have expressed their concerns regarding the results being biased toward patients with serous effusions. 11 The use of CA-125 in the diagnosis of PTB in the elderly population has been poorly studied. 11 Therefore, we conducted this study to assess the clinical value of CA-125 levels in diagnosing elderly PTB.…”

mentioning

confidence: 99%

“…11 The use of CA-125 in the diagnosis of PTB in the elderly population has been poorly studied. 11 Therefore, we conducted this study to assess the clinical value of CA-125 levels in diagnosing elderly PTB.…”

mentioning

confidence: 99%

Clinical significance of CA-125 in elderly patients with active pulmonary tuberculosis

Zhao

Liang

Xie

et al. 2022

SMJ

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Objectives: To assess the clinical significance of serum CA-125 levels in elderly patients with pulmonary tuberculosis )PTB(. Methods: We retrospectively analyzed 1613 participants-patients )aged ≥60 years( admitted to the Beijing Shijitan Hospital, Beijing, China from February 2015 to January 2021 and healthy participants, divided into 4 groups: PTB )group 1(, pulmonary malignancies )group 2(, pulmonary non-malignant diseases )group 3(, and healthy participants )group 4(. Data concerning demographics, physical examination findings, computed Original Article tomography, histopathological examination, and laboratory tests for Mycobacterium tuberculosis and serum CA-125 levels were collected and analyzed.Results: There were 720 healthy individuals and 893 patients in the study. The median levels and abnormal rates of CA-125 in groups 1 )42.5, 57.3%( and 2 )34.4, 49.5%( were higher than those in groups 3 )21.1, 29.2%( and 4 )8.6, 0.4%( )p<0.05(. The ordinal logistic regression analysis model revealed significant associations between CA-125 levels and PTB )OR and 95% confidence interval [CI]: 2.749 )1.876-4.027 ((, hypoproteinemia [OR and 95% CI: 1.519 )1.114-2.070(], serous effusion [OR and 95% CI: 7.364 )5.346-10.143(], pulmonary malignancy [OR and 95% CI: 2.206 )1.518-3.204(], respiratory failure [OR and 95% CI: 3.216 )2.087-4.956(], and cor pulmonale [OR and 95% CI: 2.990 )1.282-6.973(]. Conclusion:Although elevated CA-125 levels may serve as a potential marker for diagnosing PTB in the elderly, they are affected by multiple factors, including serous effusion. Hence, caution is warranted while using this marker.

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Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis

Cited by 7 publications

References 29 publications

Editorial: Immuno-diagnosis of active tuberculosis; are we making progress?

Editorial: Immuno-diagnosis of active tuberculosis; are we making progress?

Abdominal Tuberculosis Mimicking Ovarian Cancer: A Case Report and Review of the Literature

Clinical significance of CA-125 in elderly patients with active pulmonary tuberculosis

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