Serum CA‐125 levels in preeclampsia: A systematic review and meta‐analysis

Bellos, Ioannis; Pergialiotis, Vasilios; Loutradis, Dimitrios; Papapanagiotou, Angeliki; Daskalakis, Georgios

doi:10.1111/ijcp.13380

Cited by 6 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4. The elevation of CA-125 in PE patients in this study agreed with many previous studies [21,23,28,44], in which some authors suggesting that CA125 is a promising biochemical marker, and can reflect the severity of preeclampsia [7,11,18,21,23,28,43,[45][46][47]. "This rising level of CA-125, might be due to failure of trophoblastic invasion, and the induction of an inflammatory process within placenta, that triggers the expression of CA-125.…”

Section: Discussionsupporting

confidence: 93%

“…There are few clinical studies related to the use of CA-125 in hypertensive disorders of pregnancy with conflicting results" [20]. "However, some studies reported positive correlation between serum CA125 concentration and preeclampsia" [21][22][23][24]. "C -reactive protein (CRP) is an acute phase protein produced by hepatocyte in response to release of Pro-inflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory Mediators (CA125, CRP) and Uric Acid in Association with Severity of Preeclampsia in North Kordofan State, Western Sudan

Suliman

Awadalla

Bakheit

et al. 2022

IJBcRR

View full text Add to dashboard Cite

Introduction: Inflammatory mediators could be laboratory markers of preeclampsia, as the induction of an inflammatory process within the placenta may trigger the expression of cancer antigen 125(CA125), C-reactive protein (CRP) and uric acid (UA). Regarding the pathophysiology of pre-eclampsia, there is defective trophoblastic invasion of uteroplacental blood vessels that leads to placental ischemia, and induction of an inflammatory process within the placenta. Objective: To evaluate the association of serum levels of cancer antigen (CA125), C-reactive protein (CRP) and serum uric acid with the Severity of Preeclampsia. Materials and Methods: The study recruited 200 singleton Sudanese pregnant women. These participants were divided into two groups: control (n = 100) and cases (n = 100). The cases were further subdivided into; mild preeclampsia (n =46), and severe preeclampsia (n = 54). The study groups were well-matched in maternal age, gestational age and body mass index. Blood samples were taken for measurement of serum cancer antigen-CA125, uric acid and C - reactive protein using immune- assay and enzymatic automated chemical analysis. Results: The mean levels of cancer antigen-CA125 in mild and severe preeclampsia groups were; 21.94±5.08 (IU/ml) and 40.77±9.82 (IU/ml) respectively, which were significantly higher, (P<0.001) in comparison with the control group (16.88±7.36 (IU/ml). The mean levels of C-reactive protein in mild and severe preeclampsia were; 15.17±5.35 (mg/L), 31.49±12.56 (mg/L) respectively. There was significant difference in their levels, compared to the control group (4.79±1.78 (mg/L), (P<0.01). Also, the mean levels of uric acid in mild and severe cases were; 6.44±1.98 and 7.37±2.00 which was significantly higher, in comparison with the control (4.00±0.61); (P<0.001). The level of uric acid also, showed significant difference within the case (severe and mild) group (P<0.05). CA125, CRP and UA level‎s correlated positively with Mean Arterial blood pressure (MAP), (r>0.7; P < 0.001). ROC curve validate the utility of these biomarker for the detection of preeclampsia severity (AUC>0. 8; P < 0.001). Conclusion: Serum cancer antigen 125(CA125), C- reactive protein and uric acid in studied preeclampsia groups were found to be significantly higher compared with the control group, and the rises were directly associated with the severity of preeclampsia.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Inflammatory Mediators (CA125, CRP) and Uric Acid in Association with Severity of Preeclampsia in North Kordofan State, Western Sudan

Suliman

Awadalla

Bakheit

et al. 2022

IJBcRR

View full text Add to dashboard Cite

show abstract

“…comparison with the control group (p<0.001) which was observed in the current study, coinciding with many previous studies [21,23,28] in which some authors suggested that CA-125 is a promising biochemical marker and can reflect the severity of preeclampsia [18,21,23,28,41]. This rise might be due to failure in trophoblastic invasion and the induction of an inflammatory process within the placenta that triggers the expression of CA-125 and is anticipated to be an essential mechanism for the elevation of serum CA-125 in preeclampsia.…”

Section: Plos Onesupporting

confidence: 93%

“…There are few clinical studies related to the use of CA-125 in hypertensive disorders of pregnancy with conflicting results [20]. However, some studies reported positive correlations between serum CA-125 concentration and preeclampsia [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Cancer antigen 125 and C-reactive protein inflammatory mediators and uric acid in association with preeclampsia in North Kordofan State, Western Sudan

et al. 2023

View full text Add to dashboard Cite

Pathophysiology of pre-eclampsia depends on a defective trophoblastic invasion of uteroplacental blood vessels that leads to placental ischemia and induction of an inflammatory process within the placenta. This process may trigger the expression of Cancer antigen 125 (CA 125), C-reactive protein (CRP) and uric acid (UA). This research aimed to evaluate the association of serum CA 125, CRP and uric acid with Preeclampsia. The study recruited 200 singleton Sudanese pregnant women, who were divided into three groups: controls (n = 100), mild preeclampsia (n = 46) and severe preeclampsia (n = 54). The study subjects were matched for maternal age, gestational age and body mass index. Blood samples were taken for measurement of the different variables using immune- assay and enzymatic automated chemical analysis. The levels of CA 125 in mild and severe preeclampsia were (21.94±0.749 IU/ml) and (40.78±1.336 IU/ml) respectively, which was significantly different (P<0.001) from the control mean (16.48±0.584 IU/ml). There was also a significant difference between the mean levels of CRP in mild and severe preeclampsia (15.17±0.788 mg/L), (31.50±1.709 mg/L) compared with controls (4.79±0.178 mg/L), (P<0.01). There was also a significant difference in the mean levels of UA in mild and severe cases (6.44±0.293 and7.37±0.272) in comparison with the controls (4.00±0.061); (P<0.001). There were significant differences between severe and mild groups (P<0.05). Cancer antigen 125, CRP and UA levels‎ correlated positively with mean arterial blood pressure (MAP) where (r >0.7; P < 0.001). ROC curve validates the utility of these biomarkers for monitoring preeclampsia (AUC >0.8; P < 0.001). In conclusion CA 125, CRP and UA were significantly higher in preeclampsia compared with the controls. The rise of the analytes was directly associated with the severity of the disease.

show abstract

“…Studies have shown that cancer antigen (CA) 125 values increase during pregnancy and in cases of preeclampsia [12]. Considering that HE4 has been associated with many diseases, such as cancer and endometriosis, diseases that are also associated with increased CA 125 levels, it is necessary to investigate the relationship between preeclampsia and HE4 [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Exploring the relationship between preeclampsia and human epididymis protein 4

et al. 2022

View full text Add to dashboard Cite

Background/Aim: The level of human epididymis protein 4 (HE4), a glycoprotein and protease inhibitor, increases under many malignancies and inflammatory conditions. HE4 is also associated with cell invasion, migration, and adhesion. In this study, we compared the HE4 protein levels in pregnant patients with preeclampsia to healthy pregnant and non-pregnant individuals with the aim of finding a biomarker that can be used to recognize preeclampsia. Methods: Our study is a prospective case control study and included 20 pregnant women with preeclampsia, 20 pregnant women without preeclampsia, and 20 healthy non-pregnant women (the control). The participants’ serum HE4 levels were analyzed statistically. Results: Data analysis revealed that the mean HE4 levels were significantly lower in the preeclampsia group than in the other two groups (P = 0.002). Mean HE4 protein levels were also lower in the non-pregnant women than in the pregnant women without preeclampsia; however, this difference was not significant. Conclusion: It is difficult to predict preeclampsia, and there is not any sensitive or specific biomarker for determining the condition. This study may support that HE4 protein may be useful and significant in predicting preeclampsia. The results we achieved provide proof that HE4 levels could be a potential biomarker for preeclampsia. Many more comprehensive studies are needed to support the association between HE4 protein and preeclampsia.

show abstract

Serum CA‐125 levels in preeclampsia: A systematic review and meta‐analysis

Cited by 6 publications

References 27 publications

Inflammatory Mediators (CA125, CRP) and Uric Acid in Association with Severity of Preeclampsia in North Kordofan State, Western Sudan

Inflammatory Mediators (CA125, CRP) and Uric Acid in Association with Severity of Preeclampsia in North Kordofan State, Western Sudan

Cancer antigen 125 and C-reactive protein inflammatory mediators and uric acid in association with preeclampsia in North Kordofan State, Western Sudan

Exploring the relationship between preeclampsia and human epididymis protein 4

Contact Info

Product

Resources

About