Serum CA19-9 levels in rheumatic diseases with interstitial pneumonia.

Yamamoto, Shuichi; Kobayashi, Shigeto; Tanaka, Mitsuhiko; Akimoto, Tomohiro; Takasaki, Yoshinari

doi:10.2177/jsci.19.128

Cited by 14 publications

(12 citation statements)

References 19 publications

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“…6 Therefore, it is considered that increased CA 19-9 levels might be related to the pulmonary involvement of inflammatory diseases. 7,11 Although we have not detected any malignancies in our patients with RA, a study reported pancreatic mucinous cystadenocarcinoma without elevated tumor marker and ovarian adenocarcinoma with elevated CA 125 in RA patients during follow-up. 10 In a meta-analysis on the assessment of RA-associated malignancy risk, an increased risk has been shown for particularly lymphoma and lung cancer, as well as a potential risk reduction in colorectal cancer and breast cancer.…”

Section: Carcinoembryonic Antigenmentioning

confidence: 57%

“…10 Also, increased cancer antigen (CA) 19-9 levels were reported in rheumatic diseases as a useful marker for interstitial pneumonia. 11 Additionally, tumor markers were within normal range except CA 125 in a RA patient diagnosed with ovarian adenocarcinoma on the follow-up. 10 The relationship between TAAs and clinical features in RA patients remains uncertain and the relevant data are still lacking.…”

Section: Citationmentioning

confidence: 90%

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Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy?

2018

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Objectives:This study aims to evaluate the serum tumor-associated antigen (TAA) levels and the possible association between these markers and interstitial lung disease (ILD) or malignancy in rheumatoid arthritis (RA) patients. Patients and methods:The study included 83 RA patients (20 males, 63 females; mean age 59.3±12.1 years; range 25 to 83 years), 43 with ILD (13 males, 30 females; mean age 60.1±11.5 years; range 25 to 83 years) and 40 without ILD (7 males, 33 females; mean age 58.5±12.7 years; range 28 to 78 years). Clinical symptoms, pulmonary function test, chest X-ray, and high-resolution computed tomography were used for the diagnosis of ILD. Age, sex, history of smoking, acute-phase reactants, rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP), carcinoembryonic antigen (CEA), cancer antigen (CA) 15-3, CA 125, and CA 19-9 were evaluated. The relationship between parameters in RA patients with/without ILD was assessed by t-test and Mann-Whitney U test.

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Section: Carcinoembryonic Antigenmentioning

confidence: 57%

Section: Citationmentioning

confidence: 90%

Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy?

2018

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“…CA-19-9 seviyesi intersitisyel akciğer hastaliği olan kişilerde yüksek saptanmiştir. Ayrica diffüz panbronşiolit, amfizem, fibrozis, bronşektazi gibi çeşitli benign akciğer hastaliklarinda da serum CA-19-9 düzeylerinde artiş gösterilmiştir [12]. Szekanecz ve ark.…”

Section: Discussionunclassified

“…Yapilan bir diğer çalişmada romatoid artrit, SSc, polimiyozit, dermatomiyozit tanili intersitisyel akciğer hastaliği olan hastalarda bulunan CA-19-9 yüksekliği ile DLCO arasinda ters ilişki olduğu saptanmiştir. Verilen anti-inflamatuar tedavi ile CA-19-9 yüksekliği azalmiştir [12]. Sistemik skleroz [SSc], polimiyozit, dermatomiyozit, romatoid artrit akciğer tutulumlarinda, akciğerin kronik fibrotik değişiklik sürecinde bronşiyal bez hücrelerinde metaplastik dönüşüm oluştuğu ve bronşiyal bez hücrelerinde CA-19-9 ürettiği raporlanmiştir [12].…”

Section: Discussionunclassified

“…Verilen anti-inflamatuar tedavi ile CA-19-9 yüksekliği azalmiştir [12]. Sistemik skleroz [SSc], polimiyozit, dermatomiyozit, romatoid artrit akciğer tutulumlarinda, akciğerin kronik fibrotik değişiklik sürecinde bronşiyal bez hücrelerinde metaplastik dönüşüm oluştuğu ve bronşiyal bez hücrelerinde CA-19-9 ürettiği raporlanmiştir [12]. Sjögren sendromunda saptanan serum CA-19-9 yüksekliğinin, inflamatuar süreç sonucunda oluşan pankreatik kanal obstrüksiyonu ve zedelenen hücrelerin yüzeyindeki antijenlerin ortaya çikmasi sonucunda olduğu düşünülmektedir.…”

Section: Discussionunclassified

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Increased serum tumor markers in a patient with rheumatoid arthritis

Bayğın¹,

Sargın²,

Şentürk³

et al. 2017

Pau Med J

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ÖzetTümör ilişkili antijenler, malignitelerde takip ve tedaviye yanitin değerlendirilmesinde kullanilir. Antijenler inflamatuar hücreler tarafindan eksprese edilebilir ve malin hücrelerin adezyon ve metastazlarinda önemli rol oynabilir. İnflamatuar romatizmal hastaliklarin akciğer tutulumu ve plevral effüzyonu bulunan hastalarda tümör ilişkili antijen seviyelerinin arttiği rapor edilmiştir. Biz, RA tanili bir kadin hastada tümör belirteçleri ile hastalik aktivitesi arasindaki ilişkiyi sunmayi amaçladik. Bir yildan beri RA tanisi olan 61 yaşinda kadin hasta, sağ dizde, her iki el bileğinde ve metakarpofalangeal eklemlerde şişlik ve hassasiyet olmasi nedeniyle kliniğimize başvurdu. Özgeçmişinde leflunomid 20 mg/gün ve sulfasalazin 2 gr/gün kullanimi dişinda bir özellik yoktu. Fizik muayenede bilateral akciğer alt zonda raller mevcuttu. Hastanin laboratuvar verileri: hastalik aktivite skoru : 6,02, eritrosit sedimentasyon hizi [ESH]: 72 mm/h, CRP: 37,95 mg/l, romatoid faktör: 48,5 IU/ml, anti-CCP: 67,1 U/ml, CA19-9: 410,67 U/ml [0-37 U/ml], CA-125: 197,1 U/ml [0-35 U/ml] ve CA-15-3: 51,6 U/ml [0-31,3 U/ml] idi. Postero-anterior akciğer grafisinde bilateral orta ve alt zonlarda retiküler dansite artişi ve toraks BT'de her iki akciğerde retiküler, buzlu cam opasiteleri ve ince bal peteği değişiklikleri görüldü. Malignite lehine herhangi bir kanit yoktu ve aktif hastaliği olan hastaya anti-inflamatuar tedavi verildi. Takiplerde, ESH, CRP, DAS-28, CA19-9, CA-125 ve CA15-3 düzeyleri geriledi. RA' da hastalik aktivitesini, organ hasarini ve tedaviye yaniti belirlemek için ideal biyobelirteçlere ihtiyaç vardir. Bağ doku hastaliklarinda organ tutulumu ile tümör belirteçleri arasindaki ilişki nedeniyle, bu biyobelirteçler hastalik progresyonu ve tedaviye yanitin değerlendirilmesinde yardimci olabilir. Tümör belirteçleri, malignite ekarte edildikten sonra, RA hastalarinda (özellikle akciğer tutulumlu) hastalik aktivitesinin değerlendirilmesinde kullanilabilir. Pam Tıp Derg 2017;10(1):81-85Anahtar sözcükler: Romatoid artrit, tümor belirteçleri, hastalik aktivitesi. AbstractTumor-associated antigens are used to assess the response to treatment and follow-up of malignancies.They may be expressed by inflammatory cells, and play an important role in the adhesion and metastasis of malignant cells. Increased level of tumor associated antigens were reported in patients with pleural effusion and pulmonary involvement of inflammatory rheumatic diseases.We aimed to present the relationship between tumor markers and disease activity in a female patient diagnosed with RA.61-year-old female patients diagnosed with RA since one year was admitted to our clinic with the tenderness and swelling of her right knee, both wrists and metacarpophalangeal joints. She had no medical history, except for taking leflunomide 20 mg/day and sulfasalazine 2 g/day.Physical examination revealed bilateral pulmonary crackles in the lower zone. The laboratory findings of the patients were as follows: Disease activity score was 6.02,erythrocyte sedimentation rat...

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Computed tomography of pulmonary changes in rheumatoid arthritis: carcinoembryonic antigen (CEA) as a marker of airway disease

et al. 2016

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Rheumatoid arthritis (RA) classically affects the joints, but can present extra-articular manifestations, including pulmonary disease. The present study aimed to identify possible risk factors or laboratory markers for lung involvement in RA, particularly the presence of rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), and tumor markers, by correlating them with changes observed on chest high-resolution computerized tomography (HRCT). This cross-sectional study involved RA patients who were examined and questioned by a specialist physician and later subjected to chest HRCT and blood collection for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), ACPA (anti-vimentin and/or anti-CCP3), and the tumor markers carcinoembryonic antigen (CEA), CA 125, CA 15-3, and CA 19-9. A total of 96 patients underwent chest HRCT. The most frequent findings were bronchial thickening (27/28.1 %) and bronchiectasis (25/26 %). RF was present in 63.2 % of patients (55/87), and ACPA (anti-vimentin or anti-CCP3) was present in 72.7 % of patients (64/88). CEA levels were high in 14 non-smokers (37.8 %) and 23 smokers (62.2 %). CA-19-9 levels were high in 6 of 86 patients (7.0 %), CA 15-3 levels were high in 3 of 85 patients (3.5 %), and CA 125 levels were high in 4 of 75 patients (5.3 %). Multivariate analysis indicated a statistically significant association between high CEA levels and the presence of airway changes in patients with RA (p = 0.048). CEA can serve as a predictor of lung disease in RA and can help identify individuals who require more detailed examination for the presence of respiratory disorders.

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Serum CA19-9 levels in rheumatic diseases with interstitial pneumonia.

Cited by 14 publications

References 19 publications

Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy?

Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy?

Increased serum tumor markers in a patient with rheumatoid arthritis

Computed tomography of pulmonary changes in rheumatoid arthritis: carcinoembryonic antigen (CEA) as a marker of airway disease

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