Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers

Bogdanova, Marina V.; Рамеев, В.В.; Kozlovskaya, L V; Федоров, Е. С.; Салугина, С. О.

doi:10.17116/terarkh201688658-64

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…The level of S100A12 in the blood is increased in the patients with diabetes, which is correlated with a higher risk of cardiovascular disease development ( 139 ). Bogdanova et al detected the serum concentration of S100A12 and other acute-phase inflammatory markers in thirty-five patients with periodic disease (PD) ( 140 ). The level of S100A12 in PD was significantly higher compared to other familial periodic fevers.…”

Section: S100 Proteins As Biomarkers In Specific Diseasesmentioning

confidence: 99%

“…The level of S100A12 in PD was significantly higher compared to other familial periodic fevers. S100A12 was more sensitive to assess the subclinical activity of autoinflammatory diseases, when compared to other inflammatory biomarkers such as neutrophil counts, fibrinogen, C-reactive protein (CRP), and erythrocyte sedimentation rate ( 140 ). Similarly, the serum concentrations of S100A12, as a novel biomarker, were shown to be upregulated in patients with Familial Mediterranean fever in comparison to controls ( 141 ).…”

Section: S100 Proteins As Biomarkers In Specific Diseasesmentioning

confidence: 99%

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S100 Proteins As an Important Regulator of Macrophage Inflammation

et al. 2018

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The S100 proteins, a family of calcium-binding cytosolic proteins, have a broad range of intracellular and extracellular functions through regulating calcium balance, cell apoptosis, migration, proliferation, differentiation, energy metabolism, and inflammation. The intracellular functions of S100 proteins involve interaction with intracellular receptors, membrane protein recruitment/transportation, transcriptional regulation and integrating with enzymes or nucleic acids, and DNA repair. The S100 proteins could also be released from the cytoplasm, induced by tissue/cell damage and cellular stress. The extracellular S100 proteins, serving as a danger signal, are crucial in regulating immune homeostasis, post-traumatic injury, and inflammation. Extracellular S100 proteins are also considered biomarkers for some specific diseases. In this review, we will discuss the multi-functional roles of S100 proteins, especially their potential roles associated with cell migration, differentiation, tissue repair, and inflammation.

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Section: S100 Proteins As Biomarkers In Specific Diseasesmentioning

confidence: 99%

Section: S100 Proteins As Biomarkers In Specific Diseasesmentioning

confidence: 99%

S100 Proteins As an Important Regulator of Macrophage Inflammation

et al. 2018

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Correlations between indicators of interleukin-10 and interleukin-6 in patients with periodic disease

Jndoyan

Титаловна²,

Bablumyan

et al. 2018

Terapevticheskii arkhiv

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Aim. Determination of the concentration of interleukin-10 (IL-10) and interleukin-6 (IL-6) in serum of patients with periodic disease (PD) before and after treatment with colchicin, as well as the identification of correlation between the indicators of these parameters. Materials and methods. We examined 188 patients with PD (89 men, 99 women) aged from 12 to 69 years, as well as 44 patients with rheumatoid arthritis (RA) as a comparison group and 41 healthy people of the control group. Patients were divided into groups: 1 - PD colchicinotherapy patients with seizures without amyloidosis that do not respond to treatment maximum dose of colchicine 2.0 mg/day; 2nd-PD patients without amyloidosis, not responding to treatment 1.5 mg/day colchicine; 3rd - PD patients that responds to certain doses of colchicine (0.5 to 2.0 mg/day); 4th - PD patients without amyloidosis who did not receive treatment; 5-I of the healthy persons of the control group; 6-I - RA patients. The concentration of IL-10 in blood serum was determined by enzyme immunoassay ELISA, and IL-6 - immunochemiluminescent method. For statistical processing the computer program SPSS is used. The results were considered statistically significant at the level of reliability p

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Serum calgranulin C is a highly sensitive autoinflammation activity indicator in patients with familial periodic fevers

Cited by 2 publications

References 37 publications

S100 Proteins As an Important Regulator of Macrophage Inflammation

S100 Proteins As an Important Regulator of Macrophage Inflammation

Correlations between indicators of interleukin-10 and interleukin-6 in patients with periodic disease

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