Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis

Decembrino, Lidia; Amici, Mara De; Pozzi, Margherita; Silvestri, Annalisa De; Stronati, Mauro

doi:10.1155/2015/147973

Cited by 48 publications

(51 citation statements)

References 21 publications

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“…It has been reported that calprotectin may be considered a promising early, sensitive and specific marker of sepsis. 23 In addition, Decembrino et al 23 demonstrated that serum calprotectin concentrations are significantly higher in patients with and without neuropathy than healthy controls, suggesting that calprotectin may be a novel biomarker of neuroinflammation in diabetic peripheral neuropathy. 19 It has also been shown that serum calprotectin concentrations are increased in patients with papillary thyroid carcinoma, and the marker is positively correlated with total oxidant status and lipid hydroperoxide.…”

Section: Discussionmentioning

confidence: 99%

Calprotectin is a potential prognostic marker for polycystic ovary syndrome

et al. 2016

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Background Calprotectin is an antimicrobial, calcium and zinc-binding heterocomplex protein and has been proposed as a marker to rule out inflammatory conditions. The aim of this study was to evaluate the role of calprotectin in the diagnosis of polycystic ovary syndrome and to investigate the association between calprotectin and insulin resistance. Methods A total of 41 females with polycystic ovary syndrome and 54 age-matched without polycystic ovary syndrome were eligible for the study. Serum concentration of calprotectin was determined using enzyme-linked immunosorbent assay. Clinical characteristics, hormone and metabolic parameters were evaluated in each subject. The predictive value of serum calprotectin was assessed using receiver operating characteristic curves. Correlations between the serum calprotectin concentrations and insulin resistance were examined using Spearman's correlation. Results We found that the serum calprotectin concentrations were significantly higher in polycystic ovary syndrome compared with the non-polycystic ovary syndrome group ( P < 0.001). The area under the receiver operating characteristic curve assay yielded a satisfactory result of 0.88 (95% confidence interval 0.81-0.95; P < 0.001). The optimum cut-off was 2.4 µg/mL with a 85.2% specificity and 75.6% sensitivity for polycystic ovary syndrome diagnosis. A significant positive correlation was found between the serum calprotectin and insulin resistance. Conclusions These results suggest that calprotectin might be a useful adjunct in the diagnosis of polycystic ovary syndrome, especially those with insulin resistance.

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Section: Discussionmentioning

confidence: 99%

Calprotectin is a potential prognostic marker for polycystic ovary syndrome

et al. 2016

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“…S100A8/S100A9 proteins have pro-inflammatory properties which are characterized by the induction of pro-inflammatory cytokines and adhesion molecules in endothelial cells 34,35 . Previous findings have shown that the plasma level of S100A8/S100A9 in neonates with sepsis was found to be highly elevated 8 . The elevated level of S100A8/S100A9 amplifies inflammation and enhances the inflammatory response in infection, making it a potential therapeutic target in anti-inflammatory strategies.…”

Section: Discussionmentioning

confidence: 87%

Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses

Kingsley

Bhat

Badhe

et al. 2020

Sci Rep

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Sepsis is associated with exacerbated inflammatory response which subsequently results in multiple organ dysfunction. Sepsis accounts for high mortality and morbidity among newborns worldwide. Narciclasine is a plant alkaloid which has shown to possess anti-inflammatory properties. In this study we investigated the effect and mechanism of action of narciclasine in neonatal sepsis rat models. The excessive release of S100A8/A9 or calprotectin in neonatal sepsis could be detrimental as it could exacerbate the inflammatory responses. We found that narciclasine significantly reduced the plasma levels of S100A8/A9 and also suppressed its expression in the liver and lung. The systemic and local bacterial load was also reduced in the narciclasine treated rats. The systemic and local production of pro-inflammatory cytokines in plasma and organs (liver and lungs) was significantly reduced in the narciclasine treated rats. The histopathological studies showed that narciclasine prevents the organ damage associated with sepsis and improved the survival of neonatal rats. Sepsis increased the phosphorylated NF-κβ p65 protein expression in the liver. Narciclasine suppressed the phosphorylation of nf-κβ p65 and the degradation of NF-κβ inhibitory protein alpha. It could also suppress the expression of adaptor proteins of the toll like receptor signaling pathway viz., myeloid differentiation factor 88 (MyD88), Interleukin-1 receptor-associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6). These results suggest that narciclasine protects against sepsis in neonatal rats through the inhibition of calprotectin, pro-inflammatory cytokines and suppression of NF-κβ signaling pathway.Infection is the most important cause of morbidity and mortality in intensive care units worldwide. As the immune response to infection during the neonatal period is mostly immature it is characterized by high rates of morbidity and mortality 1-3 . Most adults are usually able to restrict the bacterial infection whereas neonates are not able to restrict the bacterial infection and develop a severe systemic inflammatory response. Sepsis is a life threatening health condition which occurs due to the severe and systemic inflammatory response to infection. This syndrome starts with dysregulated inflammation, systemic inflammatory response syndrome (SIRS) progressing to severe sepsis and septic shock 4 . It is the most common cause of death in critically ill patients in non-coronary intensive care units 5 .Despite the advancement of medical care, sepsis is one of the leading causes of morbidity and mortality among babies in the neonatal intensive care units 6 . This is mainly due to the non-specific signs and symptoms of neonatal sepsis 2 . Antibiotics and supportive care are the mainstay of treatment at present. The nosocomial pathogens are increasingly becoming resistant to the antimicrobials currently being used. Thus alternative therapeutic options such as anti-inflammatory drugs could be beneficial as neonatal sepsis is characterized by elev...

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“…Up to the present day, little is known about the course of serum calprotectin (SC) levels over time and its relationship with development of sepsis, although it was suggested by several studies as a potential marker for diagnosis in neonatal sepsis [28][29][30]. Only one study up till now studied the value of SC in identifying sepsis in adult in post-operative patients.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients

Megahed¹,

Abdel-Fattah²,

El-Sayed³

et al. 2017

SJCM

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Abstract:Calprotectin is a potent acute phase reactant with increases of more than 100 fold during inflamed conditions. We measured the diagnostic and prognostic value of serum calprotectin (SC) in septic shock. We enrolled 50 adult shocked patients admitted to intensive care unit. Then, classified into 2 groups; septic group (25) with well-defined septic shock with positive cultures. Non-septic group (25) with negative cultures or no source of sepsis. Blood samples for SC), C-reactive protein (CRP) and white blood cell count (WBCC) in the first 6 hours of ICU admission and re-obtained again on day 3. We observed the weaning of vasopressor and 7-days in ICU mortality. SC measured on day 1 was significantly higher in the septic group than the non-septic group (p<0.001). SC showed a good correlation with weaning of vasopressor (AUC was 0.764; p<0.028), while it showed relative correlation with 7-days in ICU mortality (AUC was 0.752; p<0.057) compared with other markers in the study. SC may aid in rapid identification of septic shock from non-septic shock at a cutoff of 2 µg/dl (sensitivity 92% and specificity 84%). Also the change in SC level may aid in prognostication of septic shock.

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Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis

Cited by 48 publications

References 21 publications

Calprotectin is a potential prognostic marker for polycystic ovary syndrome

Calprotectin is a potential prognostic marker for polycystic ovary syndrome

Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses

Diagnostic and Prognostic Value of Serum Calprotectin in Septic Shock Patients

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