Serum cardiac troponin T in polymyositis/dermatomyositis

Kobayashi, Shigeto; Tanaka, Mitsuhiko; Tamura, Naoto; Hashimoto, Hiroshi; Hirose, Shunichi

doi:10.1016/0140-6736(92)92262-e

Cited by 97 publications

(37 citation statements)

References 4 publications

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“…Although cardiac TnT is not found either in healthy adult skeletal muscle or in the plasma of athletes, because the troponin system is highly conserved across species, a similar response to skeletal muscle disease could occur in humans. This suggestion is supported by the recent observation of Kobayashi et al [11].…”

Section: Discussionsupporting

confidence: 81%

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Diagnostic Value of Troponin T in Neonates of Mild Pre-Eclamptic Mothers

et al. 1998

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The measurement of myocardial damage by newer, highly specific markers of myocardial damage is now possible, including cardiac structural proteins such as troponin T (TnT). In neonates of pre-eclamptic mothers, it identifies minor myocardial damage missed by other biochemical markers. The present study was designed to determine the diagnostic value of TnT concentrations in neonates of pre-eclamptic mothers. Fifteen neonates of pre-eclamptic mothers were studied (9 boys and 6 girls), and 17 healthy full-term neonates (9 boys and 8 girls) were selected as a control group. The serum TnT concentration in neonates of pre-eclamptic mothers (0.70 ng/ml) was significantly higher than that in the control group (0.10 ng/ml). In an echocardiographic study, the mean mitral peak velocity at an atrial contraction (A) value of 39 cm/s in neonates of pre-eclamptic mothers was significantly lower than that in the control group (53 cm/s), and the mean mitral peak velocity of early diastole to peak velocity of the atrial contraction (E/A) value (1.75) in neonates of pre-eclamptic mothers was significantly higher than that in the control subjects (1.23). In conclusion, our study demonstrated high levels of cardiac TnT, lower mitral A values and high mitral E/A values in neonates of pre-eclamptic mothers, presumably associated with mild myocardial damage in the neonates of pre-eclamptic mothers.

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Section: Discussionsupporting

confidence: 81%

“…Cardiac involvement was seldom clinically symptomatic, and was not always detected by echocardiogram and CK-MB. Kobayashi et al [11] reported that TnT was higher in these groups. In marathon runners a potential cardiac risk was shown by a slight increase in TnT [12].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Troponin T in Neonates of Mild Pre-Eclamptic Mothers

et al. 1998

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“…Specifically, these studies have shown an increased global cardiac expression of the fetal isoform HCTnT4 in HCM (4% to 12% overall) relative to the predominant adult isoform HCTnT3 [7,[17][18][19][20][21][22]. Despite a modest overall increase in relative HCTnT4 expression, regional variation in cardiac sarcomeric protein isoform expression is well-established [23,24].…”

Section: Severalmentioning

confidence: 99%

WITHDRAWN: The troponin T isoform shift may constitute a protective compensatory mechanism in hypertrophic cardiomyopathy

Sirpal¹,

Potter²

2008

Journal of Biological Chemistry

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“…Serum cardiac TnT is useful in patients on HD, because it does not accumulate in patients with renal failure [47,48]. Recently, serum cardiac TnT levels were reported to demonstrate false-positive results in some patients with renal failure or polymyositis [49,50]. The etiology of cardiac TnT elevation in renal failure or polymyositis is considered related to regeneration of skeletal muscle associated with denervation or cold injury [51,52].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Atherogenic Indices in Patients on Hemodialysis

et al. 2000

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Atherosclerotic diseases (ASD) are the major cause of mortality and morbidity in patients on hemodialysis (HD). To evaluate the significance and usefulness of atherogenic indices, we examined lipoprotein(a) (Lp(a)), remnant-like particles cholesterol (RLP.C), homocysteine (Hcy), cardiac troponin T (TnT), and ankle-arm blood pressure index (AABI) in 114 patients on HD (male 79, female 35; age 62.1 ± 1.3 years). As a result, serum cardiac TnT and AABI levels in patients with diabetes mellitus (DM) (n = 33) were significantly higher than those in patients without DM (n = 81). In patients with cerebrovascular diseases (CVD), serum levels of both RLP.C and Hcy, and AABI levels were significantly higher than those in patients without CVD. In patients with coronary artery diseases (CAD), serum cardiac TnT and AABI levels were significantly higher than those in patients without CAD. In patients with peripheral vascular diseases (PVD), serum levels of both Hcy and cardiac TnT were significantly higher than those in patients without PVD. Multiple regression analysis did show that the presence of DM, serum Hcy levels and age were independent factors as- sociated with ASD: ASD = –0.348 + 0.426 × DM (scored: 0, absence; 1, presence) + 0.005 × Hcy (nmol/ml) + 0.010 × Age (years) (p < 0.001). In conclusion, the presence of DM and advanced age are major determinants for atherosclerosis. In addition, serum Hcy levels are independent risk factors for atherosclerosis irrespective of the absence of DM.

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Serum cardiac troponin T in polymyositis/dermatomyositis

Cited by 97 publications

References 4 publications

Diagnostic Value of Troponin T in Neonates of Mild Pre-Eclamptic Mothers

Diagnostic Value of Troponin T in Neonates of Mild Pre-Eclamptic Mothers

WITHDRAWN: The troponin T isoform shift may constitute a protective compensatory mechanism in hypertrophic cardiomyopathy

The Significance of Atherogenic Indices in Patients on Hemodialysis

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