Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

Roos, Anneclaire J. De; Arab, Lenore; Renner, Jordan B.; Craft, Neal E.; Luta, George; Helmick, Charles G.; Hochberg, Marc C.; Jordan, Joanne M.

doi:10.1079/phn2001132

Cited by 23 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Framingham OA Cohort Study showed that β-carotene intake reduced the risk of progression of knee OA [ 7 ]. A case–control study performed by De Roos and colleagues, however, found that those in the highest tertile of serum lutein or β-cryptoxanthin were less likely to have knee OA than controls, and those in the highest tertile of serum β-carotene or zeaxanthin were more likely to have knee OA [ 28 ]. In contrast, our study found that the lutein and zeaxanthin intake was associated with a decreased risk of cartilage defects, and that β-cryptoxanthin intake was associated with a decreased tibial plateau bone area – both suggesting a beneficial effect on the knee.…”

Section: Discussionmentioning

confidence: 99%

“…Although serum measures reflect the dietary intake of the carotenoids, they also reflect differences in interindividual absorption and metabolism. Moreover, when examining the effect of carotenoid intake on the knee, we used a more sensitive method of assessing knee structure than the Framingham study and De Roos and colleagues' study, which used radiographic assessment of the knee joint [ 7 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

et al. 2007

View full text Add to dashboard Cite

The aim of the present study is to examine the effect of dietary antioxidants on knee structure in a cohort of healthy, middleaged subjects with no clinical knee osteoarthritis.Two hundred and ninety-three healthy adults (mean age = 58.0 years, standard deviation = 5.5) without knee pain or knee injury were selected from an existing community-based cohort. The intake of antioxidant vitamins and food sources by these individuals was estimated from a food frequency questionnaire at baseline. The cartilage volume, bone area, cartilage defects and bone marrow lesions were assessed approximately 10 years later using magnetic resonance imaging.In multivariate analyses, higher vitamin C intake was associated with a reduced risk of bone marrow lesions (odds ratio = 0.50, 95% confidence interval (CI) = 0.29-0.87, P = 0.01) and with a reduction in the tibial plateau bone area (β = -35.5, 95% CI = -68.8 to -2.3, P = 0.04). There was an inverse association between fruit intake and the tibial plateau bone area (β = -27.8, 95% CI = -54.9 to -0.7, P = 0.04) and between fruit intake and the risk of bone marrow lesions (odds ratio = 0.72, 95% CI = 0.52-0.99, P = 0.05). Neither fruit intake nor vitamin C intake was significantly associated with the cartilage volume or cartilage defects. Lutein and zeaxanthin intake was associated with a decreased risk of cartilage defects (odds ratio = 0.71, 95% CI = 0.51-0.99, P = 0.04), and vitamin E intake tended to be positively associated with the tibial plateau bone area (β = 33.7, 95% CI = -3.1 to 70.4, P = 0.07) only after adjusting for vitamin C intake. The β-cryptoxanthin intake was inversely associated with the tibial plateau bone area after adjusting for vitamin E intake (β = -33.2, 95% CI = -63.1 to -3.4, P = 0.03). Intake of vegetables and other carotenoids was not significantly associated with cartilage or bone measures.The present study suggests a beneficial effect of fruit consumption and vitamin C intake as they are associated with a reduction in bone size and the number of bone marrow lesions, both of which are important in the pathogenesis of knee osteoarthritis. While our findings need to be confirmed by longitudinal studies, they highlight the potential of the diet to modify the risk of osteoarthritis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Using serum biomarkers of antioxidant status, Jordan and colleagues [42] reported that the relative frequencies of isoforms of tocopherols might be important in OA, showing that subjects in the Johnston County Osteoarthritis Project who had a high ratio of alpha:gamma tocopherol were 50% less likely to have radiographic knee OA. In the same study, those in the highest tertile of serum lutein and beta-cryptoxanthine also were less likely to have radiographic knee OA [43]. Subjects who had low levels of selenium, another anti-oxidant measured in toenails, were more likely to have radiographic knee OA, bilateral knee OA, and severe knee OA [44].…”

Section: Systemic Risk Factors For Osteoarthritismentioning

confidence: 99%

Epidemiology of Osteoarthritis

Zhang¹,

Jordan²

2008

Rheumatic Disease Clinics of North America

473

241

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common joint disorder in the United States [1]. Symptomatic disease in the knee and hip occurs in approximately 6% and 3%, respectively, of adults 30 years of age or older [2]. From 1995 to 2005, the number people affected with symptomatic OA has grown from 21 million to nearly 27 million in the United States, probably reflecting the aging of the population and the obesity epidemic [3]. Pain from OA is a key symptom in the decision to seek medical care and is an important antecedent to disability [4]. Because of its high prevalence and the frequent disability that accompanies disease in major joints such as the knee and hip, OA accounts for more trouble with climbing stairs and walking than any other disease [5] and is the most common reason for total hip and total knee replacement [6]. The rapid increase in the prevalence of this already common disease suggests that OA will have a growing impact on health care and public health systems in the future [3].

show abstract

“…The Framingham OA Cohort Study revealed that intake of beta-carotene was associated with reduction of progression of symptomatic knee OA 6 . Another study presented participants with increased levels of serum lutein or beta-cryptoxanthin developed knee OA to a lesser degree, on the contrary, it was more possible participants with the highest concentrations of serum beta-carotene or zeaxanthin to develop knee OA 40 .…”

Section: Antioxidantsmentioning

confidence: 99%

The role of Mediterranean diet and it’s components on the progress of osteoarthritis

Pitaraki¹

2017

JFSF

View full text Add to dashboard Cite

Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project

Cited by 23 publications

References 30 publications

Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

Epidemiology of Osteoarthritis

The role of Mediterranean diet and it’s components on the progress of osteoarthritis

Contact Info

Product

Resources

About