Serum chemerin levels are inversely associated with renal function in a general population

Abstract

SummaryObjective: Chemerin has been found to be highly expressed in the kidneys of rodents and has been suggested to affect metabolic syndrome (MetS)-related phenotypes which are in turn related to kidney damage. Only few clinical studies have addressed the relation between circulating chemerin and renal function in humans, and no populationbased analyses have yet been performed. The potential influence of MetS-related phenotypes on the assumed association has been largely neglected. We aimed to investigate the association of serum chemerin with renal function in a general population with special regard to possible interactions between chemerin and metabolic phenotypes.Design, patients and measurements: Linear and logistic regression models were applied to analyse data from 4082 subjects of the German Study of Health in Pomerania.Main outcomes included estimated glomerular filtration rate (eGFR), serum creatinine and cystatin C and chronic kidney disease. Results:Inverse associations of chemerin with eGFR were observed. The components of the MetS emerged as modulating factors in this relation and enhanced the association. Logistic regression models confirmed the relation between chemerin and eGFR and revealed that each increase in chemerin per 25 ng/mL was associated with an about threefold higher odds of chronic kidney disease [odds ratio 2.72 (95% confidence interval 2.26-3.29)].Conclusions: Our results demonstrate a strong inverse association between serum chemerin levels and renal function. This association might be explained by MetS-related phenotypes, which lead to renal damage and are associated with increased chemerin levels and/or an impaired renal elimination of chemerin by diseased kidneys. K E Y W O R D Sadipokines, blood circulation, chronic kidney disease, diabetes mellitus, dyslipidaemia, hypertension, obesity

Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease

“…Importantly, in patients with CAD, chemerin is significantly and independently associated with the glomerular filtration rate (GFR) , and similar findings have been reported also in the general population and in subjects with diabetes . Furthermore, chemerin levels are higher in subjects with chronic kidney disease (CKD) as compared with control subjects and normalize after kidney transplantation .…”

Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension

“…This is particularly interesting, as inhibition of CMKLR1 via novel small molecule antagonist α-NETA resulted in a 2.26 hour phase shift in diurinal rhythm versus vehicle treated SS rats ( Figure S3). Additionally, there exists a strong inverse association between serum chemerin levels and renal function, where diseased kidneys have an impaired ability to eliminate chemerin 56 . The current study is the first to demonstrate that immune cells infiltrating the target organ differentially express CMKLR1 in response to dietary modulations, and has determined a deleterious role for CMKLR1 expressed on T-cells specifically in the Dahl SS rat.…”

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy

“…in an ordinary population 20 and incident dialysis patients. 21 Type 2 diabetes patients with macroalbuminuria also showed significantly elevated serum levels of chemerin.…”