Serum chitotriosidase enzyme activity is closely related to HbA1c levels and the complications in patients with diabetes mellitus type 2

Turan, Emre; Sözmen, Bülent; Eltutan, Mine; Sözmen, Eser Yıldırım

doi:10.1016/j.dsx.2017.03.044

Cited by 11 publications

(12 citation statements)

References 15 publications

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“…The difference became even more important if neuropathy was associated with long-term disease duration (average time length of 22 years, with a lower limit of 10 years). These results are consistent with those reported in patients with type 2 DM, affected by this complication [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

“…In this study, patients with retinopathy (regardless of its progression) had significantly higher values of serum chitotriosidase, than those in whom retinopathy was still undetected. Our results support those observed in patients with type 2 DM and retinopathy, where the protein YKL-40, a member of the same family as chitotriosidase, had been proposed as a predictive marker of macular oedema and retinal detachment [ 7 , 25 , 28 , 29 ]. As in the case of neuropathy, serum levels of neopterin were increased in patients with retinopathy, but this variation lacked statistical significance.…”

Section: Discussionsupporting

confidence: 90%

“…During the entire length of disease evolution, circulating chitotriosidase increased progressively, a tendency that was positively correlated with UACR and negatively correlated with GFR. Similarly, the relationship between elevated serum chitotriosidase (and also YKL-40) and the occurrence of albuminuria has already been reported in patients with type 2 DM [24,25,31,32]. Again, neopterin variation did not reach statistical significance among our patients with diabetic nephropathy, although there is evidence of a relationship between elevated neopterin levels and the progression of kidney disease in patients with type 1 DM [33].…”

Section: Discussionsupporting

confidence: 74%

“…As biomarkers of macrophage activation, both chitotriosidase and chitinase-3-like protein 1 (CHI3L1), also called YKL-40, have been studied mainly in patients with type 2 DM. Previous studies have shown that in both type 1 and 2 DM, chitotriosidase activity was correlated with age, GFR and UACR, but not with glycaemia or HbA1c [ 22 , 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus

et al. 2021

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The chronic complications of diabetes mellitus (DM) are accompanied by inflammatory manifestations. Our study aimed to evaluate a possible association between the inflammatory status (reflected by serum chitotriosidase and neopterin) and the timely evolution and occurrence of chronic microvascular complications in patients with type 1 DM. This observational, cross-sectional study included 82 type 1 DM patients from the Centre for Diabetes, Nutrition and Metabolic Diseases, Cluj-Napoca, Romania. Our results demonstrated a link between the extent of inflammation, evaluated by the enzymatic activity of circulating chitotriosidase, and the onset of microvascular complications, especially diabetic neuropathy and retinopathy. Chitotriosidase enzymatic activity showed an ascending evolution over time. In non-smoking patients, the increase in chitotriosidase activity was correlated with the extent of microalbuminuria and the decline of glomerular filtration rate, while in smokers, only the presence of a positive correlation between chitotriosidase activity and disease progression was noticed. According to our results, the time span between the moment of diagnosis and the onset of microvascular complications was longer in non-smokers than in smokers. These results also imply that increased chitotriosidase activity may be a predictor of endothelial dysfunction in type 1 DM.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus

et al. 2021

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“…Currently, it is used as a biochemical marker for the diagnosis and monitoring of lysosomal storage diseases [5][6][7]. Studies have reported high activities of ChT in a wide range of diseases such as atherosclerosis, malaria, bronchial asthma, sarcoidosis, non-alcoholic steatohepatitis, diabetes mellitus (DM), Alzheimer's disease, cancer, and thalassemia [8][9][10][11][12]. High ChT activity is reportedly associated with a high risk of cardiovascular events [13].…”

Section: Introductionmentioning

confidence: 99%

A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase

et al. 2021

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Background/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Materials and methods:This cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results:The patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 ± 11.4 vs. 17.5 ± 10.4 μmol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042). Conclusion:Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.

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Utility of amniotic fluid chitotriosidase in the prenatal diagnosis of lysosomal storage disorders

Kadali¹,

Madalasa²,

Reddy³

et al. 2018

Clinical Biochemistry

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Serum chitotriosidase enzyme activity is closely related to HbA1c levels and the complications in patients with diabetes mellitus type 2

Cited by 11 publications

References 15 publications

Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus

Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus

A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase

Utility of amniotic fluid chitotriosidase in the prenatal diagnosis of lysosomal storage disorders

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