Serum Cholesterol Concentration in New-Born African and European Infants and their Mothers

Bersohn, I; Wayburne, S.

doi:10.1093/ajcn/4.2.117

Cited by 34 publications

(2 citation statements)

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“…Although there is no evidence to explain this difference in changes of serum lipid levels between humans and WHHLMI rabbits, the difference in dietary habits between these species may relate to changes in the serum lipid levels. Although serum cholesterol levels of newborn rabbits (80-100 mg/dl) [3,10] are similar to those of newborn infants (50-70 mg/dl) [1,23], humans ingest animal fats, which relate to an increase in serum lipid levels. The gender difference in serum lipid levels of humans is considered to be due to the estrogen function in females.…”

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Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

et al. 2004

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Abstract:We developed myocardial infarction-prone rabbits (WHHLMI rabbits) by selectively breeding coronary atherosclerosis-prone WHHL rabbits. To examine the serum/ plasma biochemical parameters of this animal model, we assayed the lipid and glucose levels, and enzyme activities of WHHLMI rabbits from 2 to 26 months of age using solid phase analysis. The results showed a good correlation with those measured with a conventional method. The serum enzyme activities and lipid levels varied with aging despite almost no change in the plasma glucose levels. Gender differences were observed in the total cholesterol, triglyceride, and lactate dehydrogenase activity levels. The data on these serum/plasma biochemical parameters will be useful in studies of myocardial infarction or pharmacological studies using this model. Key words: biochemical parameters, dry chemistry instrument, WHHLMI rabbitsWe have carried out pre-clinical studies of several compounds using WHHL rabbits, which show spontaneous hypercholesterolemia, hyperinsulinemia and atherosclerosis [4,12,15,16,21], to examine whether such compounds can reduce serum lipid levels, ameliorate insulin responses, or suppress atherosclerosis [13-15, 17-19, 22]. Although assays of serum/plasma biochemical parameters are important, there have been no reports on changes in these parameters with aging in this animal model or any other rabbit strain. Recently, we developed an animal model of spontaneous myocardial infarction (WHHLMI rabbit) by selectively breeding coronary atherosclerosis-prone WHHL rabbits [20]. This animal model suffers from myocardial infarction without any interventions and the findings of

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Age-Related Changes in Serum/Plasma Biochemical Parameters of WHHLMI Rabbits.

et al. 2004

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“…12 The findings for oatmeal were consistent with results from other metabolic ward studies that suggested cholesterol reduction by soluble fibers (e.g., pectin, gUms).13-l6 However, oatmeal's fiber content (7 percent) is low compared to that of oat bran (15-26 percent)17 and, as interest in dietary fibers has grown, so has the number of reports of the cholesterol-lowering potential of oat bran. In crossover metabolic ward studies of hypercholesterolemic men, with the fat content of their diets held constant, the degree of TC reduction (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) A much-discussed article by Swain, et al, questioned whether oat bran had any direct hypocholesterolemic effect. 24 The authors used a randomized, cross-over design, included large low-and high-fiber supplements, and assessed diet at baseline and toward the end of each six-week experimental period.…”

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confidence: 99%