Serum Cholesterol, Uric Acid and Proteins in Psoriasis.

Tickner, A.; Mier, P.D.

doi:10.1111/j.1365-2133.1960.tb13860.x

Cited by 26 publications

(15 citation statements)

References 17 publications

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“…TC and TG were routinely determined more pronounced in patients with severe psoriasis (2). Contrastusing enzymatic methods (15,16) and diagnostic kits supplied ing results have been observed about serum TC; it has been from Boehringher (Mannheim, Germany) on a Synchron C5 reported to be raised (22), normal (23), or lowered (24). No data analyzer (Beckman, Germany).…”

Section: Methodsmentioning

confidence: 99%

Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children

et al. 1993

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ABSTRACT. Psoriasis has been associated with an abnormal plasma lipid metabolism, and changes of erythrocyte membrane lipid composition and fluidity have been shown in adult patients. To investigate whether the alterations of plasma lipids appear also in pediatric patients, we have studied plasma lipids and lipoproteins in 15 prepubertal children affected by mild-to-moderate psoriasis with respect to healthy controls. The patients showed higher levels of plasma total cholesterol (4.44 + 0.78 versus 4.03 f 0.58 mmol/L), a significant increase of cholesterol associated with HDL (1.39 +. 0.26 versus 1.13 +. 0.28 mmol/ L, p = 0.02), and a significant decrease of the ratio LDL cholesterol to HDL cholesterol (1.73 + 0.6 versus 2.46 2 0.8, p = 0.02). By using fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene, we have shown a significant increase in fluidity in erythrocyte membrane of psoriatic children that was associated with a slight, but not significant, decrease in the cholesterol to protein ratio (422 + 127 versus 503 f 117 nmol/mg). No significant changes of phospholipid fatty acid composition have been shown, in disagreement with previous studies in adult patients. Our results support the relation between childhood psoriasis and plasma lipid changes, which are likely related to the slight compositional changes in erythrocytes. However, the observed abnormalities are expressed differently in children than in adults. (Pediatr Res 33: 506-509, 1993) Abbreviations DPH, 1,6-diphenyl-1,3,5-hexatriene HDL-C, cholesterol associated with high-density lipoprotein LDL-C, cholesterol associated with low-density lipoprotein Pf, fluorescence polarization TC, total cholesterol TG, triglyceride VLDL-C, cholesterol associated with very low-density lipoprotein Psoriasis is a chronic inflammatory skin disease characterized by an accelerated turnover of epidermal cells and an incomplete differentiation in lesional epidermidis. The etiology of psoriasis is unknown, but genetic, metabolic, and immunologic mechanisms have been proposed (1). Various disorders of the plasma lipid and lipoprotein pattern that include an increase in TG in VLDL and a decrease in HDL-C have been shown in adult

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Section: Methodsmentioning

confidence: 99%

Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children

et al. 1993

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“…T ickner and M ier [14] tell o f a 21% average o f h y p eru ricem ia in p so riatics. I t should be rem em b ered th a t from 3 to 6% o f n o rm al in d iv id u als h av e an increase o f uric acid o f over 6 m g %.…”

Section: Commentmentioning

confidence: 99%

Allopurinol in Psoriasis

et al. 1970

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We have tried Allopurinol in the treatment of psoriasis, without having any knowledge of previous publications in this respect. The antigouty drug, which acts inhibiting the xanthine oxidase has proved excellent in 50%, good in 34% and moderate in 16% of the cases treated, independent of the oldness of the process. This study constitutes a new step in the metabolic pathogenesis of psoriasis which has already been the motive of other investigatory works by the authors.

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“…This association was first noted by Herrmann et al (1930), who reported levels of uric acid above the upper limit of normal in 44 of 140 patients with psoriasis, especially in those with arthritis. Other authors reported similar findings (Steinberg et al, 1951;Tickner and Mier, 1960;Baumann and Jillson, 1960;Eisen and Seegmiller, 1961;Beveridge and Lawson, 1967;Pokorny and Resl, 1968;Solanet and Shulman, 1972). The prevalence of hyperuricaemia varied in these series from 21 to 50 %, the increase being more marked in males and in patients with arthritis.…”

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confidence: 53%

Serum Uric Acid Levels in Psoriatic Arthritis

Taccari¹,

Mc²,

Ml³

et al. 1985

Scandinavian Journal of Rheumatology

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SUMMARY Serum uric acid levels were determined in patients with psoriatic arthritis on and off medication, with rheumatoid arthritis on no medication likely to alter serum values, and in patients with uncomplicated psoriasis. Values in males were higher than those in females. A larger prevalence of values above the normal range were seen in males with psoriatic arthritis on uncontrolled medication (13-5 %) and in males with rheumatoid arthritis (12%) than in the other groups. The means for both these groups were around the midpoints of the normal range. These findings suggest that hyperuricaemia is not a common characteristic of psoriatic arthritis.Hyperuricaemia has been generally accepted as a frequent accompaniment of psoriasis and psoriatic arthritis. This association was first noted by Herrmann et al. (1930), who reported levels of uric acid above the upper limit of normal in 44 of 140 patients with psoriasis, especially in those with arthritis. Other authors reported similar findings (Steinberg et al., 1951;Tickner and Mier, 1960;Baumann and Jillson, 1960;Eisen and Seegmiller, 1961;Beveridge and Lawson, 1967;Pokorny and Resl, 1968;Solanet and Shulman, 1972). The prevalence of hyperuricaemia varied in these series from 21 to 50 %, the increase being more marked in males and in patients with arthritis. Eisen and Seegmiller (1961) found correlation of the serum uric acid level with the extent of skin involvement, and it has been postulated that the hyperuricaemia results from increased purine synthesis from the rapid epidermal cell turnover. However, their work with radioactively labelled glycine showed a pattern of turnover resembling primary rather than secondary gout.Further evidence for the association was reported by Kaplan and Klatskin (1960) who described 3 patients with psoriasis, gout, and sarcoidosis. However, Lea et al. (1958) found no difference between the values of 19 psoriatic patients and controls. Schattenkirchner (1970) found no increase in the frequency of raised serum uric acid levels in psoriatic arthritis compared with seronegative chronic polyarthritis, and Little et al. (1975) found that in patients with severe psoriasis, with or without arthritis, the mean serum uric acid levels were Accepted for publication August 19, 1976 Correspondence to Dr. J. R. Lambert, Rheumatism Research Unit, 36 Clarendon Road, Leeds LS2 9PJ in the middle of their normal range. A careful study was undertaken of our patients to try to resolve these conflicting reports. Materials and methodsThe study consisted of three parts. In the first, plasma uric acid levels were estimated in 115 patients (52 men, 63 women) with psoriatic arthritis fulfilling the criteria of Moll and Wright (1973). No account was taken of medication. Values were compared with the laboratory range of normal.In the second part of the study uric acid levels were measured on a group of 45 patients (13 men, 32 women) with psoriatic arthritis who had received only paracetamol for at least the preceding week. Values were compared with th...

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Serum Cholesterol, Uric Acid and Proteins in Psoriasis.

Cited by 26 publications

References 17 publications

Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children

Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children

Allopurinol in Psoriasis

Serum Uric Acid Levels in Psoriatic Arthritis

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