Serum-Complement in Multiple Sclerosis

Géraud, G; Boissezon, J.F. de; Castel, M.; Bès, A.; Geraud, J

doi:10.1016/s0140-6736(77)91566-5

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The results of the study made it possible to confirm that no alterations occur in the complement system in MS. All serum complement levels were normal in accord with Patzold's results (17) and in contrast to other reports of decreased (35, 36) or fluctuating (37) levels.…”

Section: Discussionsupporting

confidence: 85%

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Procaccia¹,

Lanzanova²,

Caputo

et al. 1988

Acta Neurologica Scandinavica

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We studied circulating immune complexes (IC) in the serum and cerebrospinal fluid (CSF) of patients with clinically defined multiple sclerosis (MS), in order to establish a correlation with the clinical course of the disease and to investigate the molecular composition of the IC isolated from patients in active phase of the disease. Serum IC levels were found to be significantly increased in patients from the progressive and active relapsing-remittent subgroups with both the CIC-conglutinin and C1q-binding methods. High levels of IC in CSF were detected only in the subgroup consisting of the relapsing-remittent patients in disease exacerbation when IC were determined by the C1q-binding test. No significant increase in serum or in CSF were found using the mRF-I test. The preliminary results of a qualitative investigation on serum IC in MS indicated that they are heterogeneous in nature, their size is mainly of the intermediate type, and they contain IgG, IgM, complement components and beta 2-microglobulins, the latter presenting an observation both new and interesting for studies on serum IC in MS patients.

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Section: Discussionsupporting

confidence: 85%

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Procaccia¹,

Lanzanova²,

Caputo

et al. 1988

Acta Neurologica Scandinavica

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“…The aphid Toxoptera citricida Kirk. appeared in Venezuela in 1975 (2,3 ) , from neighboring countries, and today is present in all the growing areas. The first important outbreak of the disease occurred in 1980 and since then the number of affected plants has increased every year.…”

mentioning

confidence: 99%

Spread of Citrus Tristeza Virus and Evaluation of Tolerant Rootstocks in Venezuela

Mendt¹,

Plaza²,

Boscan³

et al. 1984

International Organization of Citrus Virologists Conference Proceedings (1957-2010)

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Citrus Tristeza Virus (CTV) was detected by ELISA (enzyme-linked immunosorbent assay) in 55% of the citrus trees tested in Aragua, Carabobo, Yaracuy and Zulia States in Venezuela. High infestation with the aphid Toxoptera citricida Kirk was found in all surveyed areas. Several CTV tolerant rootstocks budded with Valencia and Washington navel oranges were compared in two different ecological areas. The following parameters were taken into consideration: foliage, volume, fruit yields, efficiency, yo of juice, OBrix and 01, of acidity. From the preliminary results the most promising rootstocks seems to be Cleopatra mandarin, Volkamer lemon, Swingle citrumelo and Troyer and Carrizo citranges. The selection of a single rootstock would not be feasible due to the different climatic and soil conditions.

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Immune complexes in multiple sclerosis

et al. 1980

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Using a C1q binding test, circulating immune complexes (IC) were detected in 33.3% of sera from 138 patients and in 19.4% of 124 spinal fluid samples from patients with multiple sclerosis. Most often they occur in sera alone. As a rule their detectable amount is small in sera as well as in spinal fluids. IC were observed with equal frequency during acute exacerbations and in stable phases of the disease. In patients with early MS of less than 3 months duration, IC were detected only rarely, whereas their frequency increased up to 50% in patients with longer standing disease. Immunosuppressive therapy has no influence on IC formation. Patients with immune complexes exhibited a more rapid clinical deterioration if compared as a group with IC-negativ ones. No correlations were found between immune complex formation and the CSF-IgG index or the rate of pleocytosis in spinal fluids. Neither the complement factors C3, C4, C3A nor total hemolytic complement activities (CH50) in serum were significantly decreased in patients with IC formation in serum as compared with the IC-negative group. The results demonstrate that IC formation probably is of no importance in the pathogenesis of multiple sclerosis.

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Serum-Complement in Multiple Sclerosis

Cited by 3 publications

References 7 publications

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Circulating immune complexes in serum and in cerebrospinal fluid of patients with multiple sclerosis

Spread of Citrus Tristeza Virus and Evaluation of Tolerant Rootstocks in Venezuela

Immune complexes in multiple sclerosis

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