Serum Complement Levels in Dogs Undergoing Kidney Homotransplantation.

Favour, Cutting B.; Murray, Joseph E.; Wemyss, Courtney T.; Colodny, Arnold H.; Miller, Benjamin F.

doi:10.3181/00379727-83-20357

Cited by 9 publications

(2 citation statements)

References 2 publications

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“…We have observed, as had been indicated by other investigations [41][42][43][44][45][46][47][48], that most of the complement components respond as acute phase reactants and often are increased in association with inflamma tion. Very pronounced increases of C3PA, and marked increases also of Cls, C4, C3, C5, and Cl, were observed in the postoperative state.…”

Section: Discussionsupporting

confidence: 71%

Effects of Anesthesia, Surgery and Inflammation Upon Host Defense Mechanisms

Schutte¹,

DiCamelli²,

Murphy³

et al. 1975

Int Arch Allergy Immunol

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Complement protein levels and C7 hemolytic activity were measured in four individuals following anesthesia and surgery, and in a group of 20 patients with inflammatory diseases. Seven of the eight complement components studied characteristically were elevated, most dramatically C1s and C3PA. Elevation of C1s often was greater than elevation of C1q, displaying an independent variation of C1s and C1q in both postoperative and inflammatory disease patient groups. The major increases of C components were seen subsequent to the peak C-reactive protein response, as was the occurrence of the ‘reactor state’, a propensity to formation of C56 which surprisingly was associated with increased levels of C7. Levels of properdin frequently were reduced postoperatively. It is concluded that multiple complement components, with the notable exception of properdin, respond as acute phase reactants which are elevated and changed in proportion postoperatively and during inflammatory disease.

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Section: Discussionsupporting

confidence: 71%

Effects of Anesthesia, Surgery and Inflammation Upon Host Defense Mechanisms

Schutte¹,

DiCamelli²,

Murphy³

et al. 1975

Int Arch Allergy Immunol

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“…In contrast to the findings in human recipients, there was no significant reduction in serum C' activity when dogs rejected renal aUografts (5,6) or when rats reacted toward skin allograffs (2), even if the donor skin was of massive dosage (9). The suppression of serum C'3 activity by a factor of cobra venom resulted in insignificant prolongation only of the survival of skin allografts in chicken and in mice and no effect on renal allograft rejection in dogs (6).…”

mentioning

confidence: 58%

Allograft Rejection in C'6 Defective Rabbits

Rother

Ballantyne

Cohen

et al. 1967

The Journal of Experimental Medicine

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27 skin allografts were transplanted in duplicate to 13 rabbits defective in the sixth component (C'6) of complement (C'). 14 were rejected within the normal period of time and 9 only after a significant delay. In four grafts, no rejection was observed. Grafts exchanged between C' active and C' defective littermates tended to persist viable longer on the C' defective partners. It is concluded that in a species of higher vertebrates, the rabbit, allograft rejection can proceed in the absence of C'6 and the biological functions depending on it. This includes the cytotoxic function of complement. However, the prolonged survival in C'6 defective rabbits of some allografts strongly suggests that two pathways may be operative in the rejection reaction. The results are consistent with the view that a mechanism independent of C'6 was alone fully effective in the majority of the donor-host combinations. A C'6-dependent mechanism became influential only in some specific donor-host combinations.

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Einige immunpathologische Aspekte des Komplements

Rother¹

1974

Komplement

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Serum Complement Levels in Dogs Undergoing Kidney Homotransplantation.

Cited by 9 publications

References 2 publications

Effects of Anesthesia, Surgery and Inflammation Upon Host Defense Mechanisms

Effects of Anesthesia, Surgery and Inflammation Upon Host Defense Mechanisms

Allograft Rejection in C'6 Defective Rabbits

Einige immunpathologische Aspekte des Komplements

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