Serum Concentration of Myelin Basic Protein as a Prognostic Marker in Mild-to-moderate Head Injury Patients: A Prospective Study in a Tertiary Care Center

Singh, Ashvamedh; Singh, Kulwant; Sahu, Anurag; Prasad, Rajniti; Pandey, Niraj Nirmal; Dhar, Sambuddha

doi:10.1055/s-0040-1716936

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The blood is centrifuged for 30 min, then the serum is placed in barcoded aliquot containers, and stored in a freezer at −70 • C for transportation to a central laboratory. Thereafter, the samples are analyzed in batches using sandwich enzyme-linked immunosorbent assays (ELISA) to s100B [100][101][102], MBP [103][104][105] and NF-L [106][107][108] (R&D Systems). All reagents are prepared at room temperature.…”

Section: Oxidative Stress (S100b Mbp and Nf-l)mentioning

confidence: 99%

Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Schimmel,

El Sayed,

Lockard

et al. 2023

IJMS

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Traumatic brain injury (TBI) results from direct penetrating and indirect non-penetrating forces that alters brain functions, affecting millions of individuals annually. Primary injury following TBI is exacerbated by secondary brain injury; foremost is the deleterious inflammatory response. One therapeutic intervention being increasingly explored for TBI is hyperbaric oxygen therapy (HBOT), which is already approved clinically for treating open wounds. HBOT consists of 100% oxygen administration, usually between 1.5 and 3 atm and has been found to increase brain oxygenation levels after hypoxia in addition to decreasing levels of inflammation, apoptosis, intracranial pressure, and edema, reducing subsequent secondary injury. The following review examines recent preclinical and clinical studies on HBOT in the context of TBI with a focus on contributing mechanisms and clinical potential. Several preclinical studies have identified pathways, such as TLR4/NF-kB, that are affected by HBOT and contribute to its therapeutic effect. Thus far, the mechanisms mediating HBOT treatment have yet to be fully elucidated and are of interest to researchers. Nonetheless, multiple clinical studies presented in this review have examined the safety of HBOT and demonstrated the improved neurological function of TBI patients after HBOT, deeming it a promising avenue for treatment.

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Section: Oxidative Stress (S100b Mbp and Nf-l)mentioning

confidence: 99%

Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Schimmel,

El Sayed,

Lockard

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“… 13 Studies have shown that serum MBP is a prognostic marker of brain injury. 14 Additionally, changes in blood MBP levels may reflect the degree of glial injury in the central nervous system; however, few clinical studies have investigated whether changes in MBP may be an index for the development of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

Zhou

Yan

et al. 2022

J Int Med Res

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Objective To explore the association between CpG island methylation in the promoter region of RELN and positive (type I) and negative (type II) types of schizophrenia, and investigate serum interleukin (IL)-1β, IL-6, and myelin basic protein (MBP) in schizophrenia. Methods Levels of CpG island methylation in the promoter region of RELN were detected in peripheral blood of patients with schizophrenia (experimental group) and healthy individuals (control group), and serum IL-1β, IL-6, and MBP were measured. Results The positive rate of CpG island methylation in the promoter region of RELN was higher in the experimental group than in the control group; however, there were no significant differences between type I and II patients. There were differences in Positive and Negative Syndrome Scale (PANSS) scores and serum IL-1β, IL-6, and MBP between type I and II patients. Furthermore, there were positive correlations between serum IL-1β, IL-6, and MBP and PANSS scores (negative symptoms) in type II patients. Conclusion CpG island methylation in the promoter region of RELN was associated with schizophrenia, but not with its clinical type. There may be different pathological mechanisms in type I and II schizophrenia, and type II schizophrenia may be associated with serum IL-1β, IL-6, and MBP.

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Serum Concentration of Myelin Basic Protein as a Prognostic Marker in Mild-to-moderate Head Injury Patients: A Prospective Study in a Tertiary Care Center

Cited by 2 publications

References 15 publications

Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Identifying the Target Traumatic Brain Injury Population for Hyperbaric Oxygen Therapy

Association between CpG island DNA methylation in the promoter region of RELN and positive and negative types of schizophrenia

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