Serum Concentrations of Insulin-Like Growth Factor (IGF)-1, IGF-2 and Unsaturated Somatomedin Carrier Proteins in Children With Chronic Renal Failure

Powell, David R.; Rosenfeld, Ron G.; Sperry, John B.; Baker, Bonita K.; Hintz, Raymond L.

doi:10.1016/s0272-6386(87)80024-0

Cited by 86 publications

(34 citation statements)

References 35 publications

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“…Because CRF serum has an excess of IGFBP relative to IGF peptides, it has been suggested that these excess IGFBP may impair IGF-mediated effects in vivo, including linear growth, and that their excess implies decreased production of IGF peptides (19,30,33,41). Initially, IGFBP-I was identified as a potential inhibitor of IGF action in CRF (19), but recently it has been suggested that low-MW IGFBP-3 forms are more likely to be inhibitors, inasmuch as their serum RIA levels are much higher than those of IGFBP-1 (33).…”

Section: Resultsmentioning

confidence: 99%

Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

et al. 1993

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Section: Resultsmentioning

confidence: 99%

Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

et al. 1993

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“…The study population, described in a previous report (8), consisted of 16 children with endstage renal failure and 16 age-and sex-matched healthy controls aged 1 to 14.5 y. Biochemical characteristics of the children with CRF include: serum urea = 8 1 k 26 mg/100 mL (mean k SD), serum creatinine = 5.9 + 2.7 mg/100 mL, serum bicarbonate = 23 11: 4 mEq/L, and GFR = 10 11: 7 mL/min/1.73 m2. None of the subjects was on glucocorticoid therapy at the time of sampling.…”

Section: Methodsmentioning

confidence: 99%

“…(Pediatr Res 26:308-315, 1989) Abbreviations CRF, chronic renal failure IGF-BP25, 25 kD IGF binding protein IGF-BP53, 53 kD IGF binding protein IGF-I and 11, also known as the somatomedins, are peptides that mediate the mitogenic actions of growth hormone (7). Serum IGF-I levels are normal in children with CRF, whereas IGF-I1 levels are elevated (8).…”

mentioning

confidence: 94%

IGF Binding Proteins in Growth-Retarded Children with Chronic Renal Failure

et al. 1989

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ABSTRACT. Changes in the normal hormonal regulation of linear growth which lead to growth failure in children with chronic renal failure (CRF) are not well understood. Previous studies indicate that serum levels of growth hormone and IGF-I and I1 are normal or elevated in this population; and that serum levels of poorly defined inhibitors of IGF action are increased. Using a recently developed RIA for the 25-kD IGF-binding protein (IGF-BP25), we report significant elevations of this protein in children with CRF when compared to age-and sex-matched controls. IGF-BP25 levels correlate positively with IGF-binding activity in both populations, indicating that the RIA reflects levels of bioactive protein. Although the variation of serum IGF-BP25 with chronologic age and IGF levels are preserved in CRF, the quantitative interrelationships are disrupted. Levels of the 53-kD IGF-binding protein, an IGFbinding protein derived from the high mol wt IGF complex, were also found to be elevated in the CRF population and, unlike in the control population, did not vary with age or IGF levels. IGF-BP25 has been shown to inhibit IGF mitogenic action in vitro. Our finding of elevated levels of IGF-BP25 in children with CRF suggests that this protein may play a role in the growth retardation of pediatric chronic renal failure. The significance of the elevated IGF-BP53 levels in CRF remains uncertain. (Pediatr Res 26:308-315, 1989)

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“…We can analyse three factors described above by measuring IGF-I and IGFBP-3 levels. Although serum levels of IGF-I were found to be normal [8][9][10] or increased [7,17] in uremia, the bioactivity of IGF-I may be found to be decreased.…”

Section: Discussionmentioning

confidence: 99%

“…IGF-I is the major growth factor involved in postnatal growth [4]. Measurements of IGF-I by radioimmunoassay (RIA) have been reported, as low [5,6], high [7] or normal [8][9][10] levels in uremic patients. Third, it has been postulated that the high levels of low molecular weight unsaturated IGF-binding protein (IGFBP) may function as a growth inhibitor in CRF.…”

Section: Introductionmentioning

confidence: 99%

Changes in Serum Levels of IGF-I and IGFBP-3 in Children with Chronic Renal Failure.

et al. 1995

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Abstract.The significance of serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) levels in uremia is still controversial.In this study we measured serum IGF-I by immunoradiometric assay (IRMA) and IGFBP-3 levels by specific radioimmunoassay (RIA) in 28 children (aged 3-16 years) with end-stage (n=14, on hemodialysis) and pre-terminal renal failure (n=14) and in 15 age-matched healthy children. Thyroid function of the patients was also investigated and GHstimulation tests with L-Dopa and insulin were performed. Neither IGF-I nor IGFBP-3 levels significantly correlated with mean height SDS for bone age or for chronological age in either non dialysis patients or pubertal (n=10) or prepubertal patients (n=18). These data was consistent with the concept that growth in CRF was not related to abnormalities in serum IGF-I or IGFBP-3 levels.

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Serum Concentrations of Insulin-Like Growth Factor (IGF)-1, IGF-2 and Unsaturated Somatomedin Carrier Proteins in Children With Chronic Renal Failure

Cited by 86 publications

References 35 publications

Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

Characterization of Insulin-Like Growth Factor Binding Protein-3 in Chronic Renal Failure Serum

IGF Binding Proteins in Growth-Retarded Children with Chronic Renal Failure

Changes in Serum Levels of IGF-I and IGFBP-3 in Children with Chronic Renal Failure.

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