Serum copeptin levels in adolescents with primary hypertension

Abstract

BackgroundThe prevalence of hypertension continues to rise in the pediatric population. In recent years, there has been an increasing amount of reports on serum arginine vasopressin and its derivative, copeptin, in blood pressure control, but its role is still unclear. The objective of this study was to assess serum copeptin in adolescents with essential hypertension.MethodsThe study cohort consisted of 84 subjects (30 girls and 54 boys) aged 11–18 years, divided into two groups: hypertension (HT) – 53 subjects with confirmed primary hypertension and R - reference group – 31 subjects in whom hypertension was excluded on the basis of ambulatory blood pressure monitoring (ABPM) (white-coat hypertension). Serum copeptin concentration was measured using a commercially available enzyme-linked immunosorbent assay kit (USCN).ResultsHypertensive patients had higher serum copeptin levels (median, 267 [Q1–Q3: 151.1–499.7 pg/ml]) than controls (median, 107.3 [Q1–Q3: 36.7–203.4 pg/ml]), (p < 0.01). Statistically significant difference was found both in males and females. In both groups, positive correlations between serum copeptin and uric acid levels (r = 0.31, p < 0.01), albuminuria (r = 0.45, p < 0.01), serum triglycerides (r = 0.3, p < 0.05), body mass index (BMI) standard deviation score (SDS) (r = 0.24, p < 0.05) and 24-h systolic blood pressure (SBP) (r = 0.37, p < 0.01) and diastolic blood pressure (DBP) (r = 0.23, p < 0.05) were found.ConclusionsIn summary, higher serum copeptin levels, a surrogate for arginine vasopressin (AVP) release, are associated not only with systolic and diastolic blood pressure but also with several components of metabolic syndrome including obesity, elevated concentration of triglycerides, albuminuria, and serum uric acid level. However, for the time being, more research is needed in order to confirm the role of serum copeptin as a novel marker of elevated blood pressure and predictor of metabolic syndrome.

Copeptin and Long-Term Risk of Recurrent Vascular Events After Transient Ischemic Attack and Ischemic Stroke

“…In fact, recent studies reported an association of copeptin levels with hypertension in middle-aged men and women 27 and with increased systolic and diastolic blood pressure on 24-hour-ambulatory blood pressure monitoring in adolescents with essential hypertension. 28 In our study, we detected higher copeptin levels in hypertensives, but the predictive value of copeptin was independent of hypertension status. However, currently, there are no data on copeptin in relation to specific blood pressure variables (such as variability or peak systolic blood pressure) in patients with stroke or TIA.…”

Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors

“…100 Third, subjects with metabolic syndrome and insulin resistance have elevated plasma copeptin levels. [101][102][103][104] Fourth, elevated levels of plasma copeptin predict development of diabetes 96,105 and obesity. 96 Although inadequate hydration and hot temperatures facilitate hyperosmolarity, it could also be enhanced by a high intake of salt with a less than adequate intake of water.…”

N-Terminal Prohormone of Brain Natriuretic Peptide but not C-Terminal Pre-Pro Vasopressin (Copeptin) Level is Associated with the Response to Antihypertensive Therapy in Haemodialysis Patients

“…However, we have previously shown that its elevated concentration predicted a rapid weight loss after kidney transplantation and characterize the subgroup of patients with greater overhydration [23]. According to previous studies, regulation of CT-proAVP metabolism in patients with chronic kidney disease is disturbed [24,25]. Plasma concentrations of CT-proAVP are greatly increased in haemodialysis patients, most likely reflecting its accumulation [26].…”