Serum cortisol-to-cortisone ratio and 11-deoxycortisol are associated with hypertension and blood pressure in Chinese rural population: a cross sectional study

Abstract

Objective: The present study aimed to investigate the associations of cortisol-to-cortisone ratio (F/E) and 11deoxycortisol (S) in hypertension and blood pressure among Chinese rural population.Methods: A total of 6233 participants from the Henan Rural Cohort Study were included. Serum cortisol (F), cortisone (E), and S were assessed using liquid chromatography-tandem mass spectrometry. Generalized linear model (GLM) and logistic regression model were performed to assess the associations of F, E, F/E, and S with blood pressure and hypertension. Moreover, the sex specificity of the associations was assessed.Results: Serum F, F/E, and S were positively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), while E was negatively associated with SBP and PP. There were no statistically significant associations of F and E with the prevalence of hypertension, while F/E and S were positively associated with hypertension [odds ratios (ORs) and 95% confidence intervals (CIs)] of F/E and S were 1.28 (1.13, 1.44) and 1.10 (1.04, 1.17), respectively. Also, the combination of high F/E and S was significantly associated with hypertension. The blood pressure indicators and the prevalence of hypertension increased with an incremental in the serum concentration of F, F/E, and S (all P trend < 0.05). In addition, the positive association between F/E and SBP was stronger in women than that in men, and F/E was strongly positively associated with hypertension only in women (all P interaction < 0.05).Conclusion: Serum F/E and S were positively associated with hypertension and blood pressure. Additionally, their combination has a synergistic effect on hypertension. Moreover, the associations of F and F/E with hypertension and blood pressure were in a sex-specific manner.

Blood Pressure Response against Sedentary Lifestyle and Caffeine Ingestion in Population: A Cross Sectional Study

“…1 Hypertension is an established risk factor for various chronic diseases, including coronary artery disease, stroke, heart failure, and kidney disease. It can shorten life expectancy, and even a small decrease in blood pressure can have a significant effect on these health outcomes 2 . In Pakistan, approximately 1 in 3 adults (78 million) have hypertension, but only about 50% of patients have their blood pressure controlled.…”