Serum cross-linked N-telopeptide of type I collagen across the canine life span: An investigation in intact and neutered male and female dogs

Yamaguchi, Fumi; Nishi, Hiroshi; Misumi, Kazuhiro; Fujiki, Makoto

doi:10.1016/j.rvsc.2021.04.008

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…While castration does not appear to significantly affect bone metabolism in female dogs, it is worth noting that androgen deficiency may impact bone metabolism in male dogs [39]. It is possible that the results of our study were influenced by the reproductive status of the subjects, potentially making the investigated population less representative of the typical DA-CSM patient population.…”

Section: Discussionmentioning

confidence: 75%

Mapping Subchondral Bone Density Distribution in the Canine C6-C7 Vertebral Endplates: A CT-OAM Study

Kramer,

Böttcher

2023

Animals

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Intervertebral cage subsidence is a common complication in treating disc-associated cervical spondylomyelopathy in dogs. The mechanical stability of the vertebral endplate in contact with the cage is crucial to preventing subsidence. This study aims to assess subchondral bone mineral density (sBMD) in the canine vertebral endplate (specifically, the C6-C7 vertebral motion unit) as a measure of its mechanical stability. The sBMD distribution was mapped for the C6 caudal and C7 cranial vertebral endplates in 15 middle- to large-breed dogs using computed tomography osteoabsorptiometry. The sBMD distribution in the canine C6 and C7 vertebral endplates exhibited a heterogeneous pattern, with lower density observed in the central and dorsal contact areas of the nucleus pulposus, where common subsidence occurs. Our results suggest a potential need to redesign intervertebral cages to ensure that contact areas align with regions of higher bone density. A broad-based design extending toward the lateral and dorsal aspects of the annulus fibrosus contact area may enhance stability.

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Section: Discussionmentioning

confidence: 75%

Mapping Subchondral Bone Density Distribution in the Canine C6-C7 Vertebral Endplates: A CT-OAM Study

Kramer,

Böttcher

2023

Animals

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“…Similarly, castration of sheep at 5-50 days from birth, thus all done far before its puberty, delated the epigenetic ageing in sheep (Sugrue et al, 2021). The impact on the lifespan of dogs is unclear when they were castrated at age of 6 months to 1 year (Yamaguchi et al, 2021).…”

Section: Confused Data From Animal Modelsmentioning

confidence: 99%

“…After the men enter the ageing stage when the production of testosterone is reducing dramatically (Figure 2d), increasing the testosterone will keep back the men remain in the reproductive stage and therefore elongate the lifespan of the men (Figure 3). (3) Most likely their ages and diseases are kept in records (Yamaguchi et al, 2021).…”

Section: Manipulation Of Testosterone Level At Different Life Stages ...mentioning

confidence: 99%

Testosterone and lifespan in males: At the right time and the right level

Wang

Yin

2022

Andrologia

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It is well known that sex features of humans are mainly regulated by sex hormones. For men, testosterone made from the testicle is the primary sex hormone. During puberty, stimulated by sex determining region Y (SRY), testosterone facilitates the development of male features such as body and facial hair, deeper voice, muscle strength, and bone mass (Dufty, 1989). In adult females, testosterone concentrations are about 15-fold lower than that in males and androgen precursors are converted to estrogens. Whilst testosterone has been recognized as the major factor for the physiological features of male,

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Healthy Long-Lived Human Beings—Working on Life Stages to Break the Limitation of Human Lifespans

2022

Biology

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The human lifespan has been increasing but will soon reach a plateau. A new direction based on the principal law of lifespan (PLOSP) may enable the human lifespan to be extremely healthy and long by the proper manipulation of the well-defined growing stages of the lifespan. The lifespan of creatures on earth from a single cell to animals can be elongated at different life stages including prenatal development, body growth, reproductivity, and aging. Each life stage has its own specific physiological and metabolic characteristics. Each life stage can be lengthened by either slowing its processes or continuously maintaining the activities of its function. Unfortunately, the current biomedical research on the extension of lifespans has mainly focused on the aging stage. Recognizing and clearly defining the periods of transition and the boundaries of life stages are essential for achieving the goal of long-lived healthy humans based on the PLOSP. The biomedical measures and pharmacological treatments for the extension of lifespans is life-stage-specific. The PLOSP can be tested with modified studies on longevity with a variety of technologies such as castration and ovariectomy. Sex differences in biological functions and the sequential order of the life stages requires different approaches for females and males.

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Serum cross-linked N-telopeptide of type I collagen across the canine life span: An investigation in intact and neutered male and female dogs

Cited by 3 publications

References 19 publications

Mapping Subchondral Bone Density Distribution in the Canine C6-C7 Vertebral Endplates: A CT-OAM Study

Mapping Subchondral Bone Density Distribution in the Canine C6-C7 Vertebral Endplates: A CT-OAM Study

Testosterone and lifespan in males: At the right time and the right level

Healthy Long-Lived Human Beings—Working on Life Stages to Break the Limitation of Human Lifespans

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