Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

Abstract

Chronic inflammation, which is suspected to play a role in the development of colorectal cancer (CRC), has rarely been studied in colorectal adenoma. We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case-control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii. We found no association of serum CRP or IL-6 levels with the risk of adenoma. A multiple regression with stepwise selection identified elevated BMI, Caucasian and Native Hawaiian versus Japanese race/ethnicity, and current smoking as being associated with significantly higher serum CRP and IL-6 levels. Female versus male gender was also associated with higher CRP levels and older age with higher IL-6 levels. The C allele of rs1205 and the A allele of rs1130864 were significantly associated with higher serum CRP levels (p (trend): 0.0002 and 0.01, respectively), as well as with a decreased adenoma risk [rs1205: OR for CT and CC vs. TT = 0.69 (95% CI: 0.48-0.98) and 0.53 (0.34-0.83), respectively, p (trend) = 0.008; rs1130864: OR for GA and AA versus GG = 0.65 (0.45-0.93) and 0.74 (0.31-1.76), respectively, p (trend) = 0.04]. The findings of lower serum CRP and IL-6 levels in Japanese (a group with a high CRC risk) and of a decreased adenoma risk observed for alleles associated with higher circulating CRP levels suggest a protective effect for CRP in early colorectal neoplasia that warrants further study.

Serum Interleukin-6, Insulin, and HOMA-IR in Male Individuals with Colorectal Adenoma

“…To our knowledge, only two previous studies have investigated the relationship between the circulating level of IL-6 and the risk of colorectal adenoma (16,17). Our findings for colorectal adenoma agree with the results of a cross-sectional study in which Kim and colleagues (16) found a positive association with the highest tertiles of IL-6 compared with the lowest tertiles.…”

“…In contrast, IL-6 levels were within the detectable range in all of our subjects using the high-sensitivity ELISA kit, allowing us to show differences in the levels of IL-6 between individuals with colorectal adenoma and controls at the low end of the concentration range. On the other hand, another case-control study of a multiethnic population showed no association between the serum concentration of IL-6 and colorectal adenoma risk (17). The present study population was rather smaller in size than those of these two previous studies, which included 873 participants (16) and 810 multiethnic participants (17), respectively.…”

“…On the other hand, another case-control study of a multiethnic population showed no association between the serum concentration of IL-6 and colorectal adenoma risk (17). The present study population was rather smaller in size than those of these two previous studies, which included 873 participants (16) and 810 multiethnic participants (17), respectively. To confirm the association between the level of IL-6 and colorectal adenoma, large-scale studies or studies covering a wide range of ethic groups will be needed.…”

“…One study has shown a positive association between the circulating level of IL-6 and the risk of colorectal adenoma (16), whereas another study has found no such association (17).…”

Genotype CC of rs1800947 in the C-Reactive Protein Gene May Increase Susceptibility to Colorectal Cancer: a Meta-Analysis

“…221 unrelated articles, 10 reviews and meta-analysis, 6 communications or letter, 7 single group design articles, 2 articles of controls were not healthy individuals and no data of two articles were excluded from the study in accordance with criteria of inclusion and exclusion. As a result, only 10 original studies (Wen et al, 2008;Motoyama et al, 2009;Pierce et al, 2009;Poole et al, 2009;Tsilidis et al, 2009;Chaturvedi et al, 2010;Ognjanovic et al, 2010;Slattery et al, 2011;Yang et al, 2011;Xu et al, 2013) were identified as eligible studies in our study. The detail flow chart of retrieval and identification and baseline characteristics of eligible studies were showed in Figure 1and Table 2 and Figure 2.…”