Serum Cystatin C for Assessment of Glomerular Filtration Rate in Hypertensive Disorders of Pregnancy

Moodley, J; Gangaram, Rajesh; Khanyile, R.; Ojwang, P. J.

doi:10.1081/prg-200030345

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…During pregnancy, there is a loss of this negative charge, which results in a reduced filtration of the positively charged cystatin C. This effect is likely to raise serum cystatin C levels. [18][19][20][21] Till now, the results in pregnancy for GFR estimated by cystatin C are conflicting. [19][20][21] It is conceivable that the accuracy of the GFR estimation in pregnancy may improve by combining serum cystatin C and creatinine in a single equation.…”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21] Till now, the results in pregnancy for GFR estimated by cystatin C are conflicting. [19][20][21] It is conceivable that the accuracy of the GFR estimation in pregnancy may improve by combining serum cystatin C and creatinine in a single equation. 22 In conclusion, our data confirm 2 previous reports on the underestimation and limited accuracy of the Cockroft-Gault and MDRD formulas in estimating GFR in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy Reduces the Accuracy of the Estimated Glomerular Filtration Rate Based on Cockroft-Gault and MDRD Formulas

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pregnancy Reduces the Accuracy of the Estimated Glomerular Filtration Rate Based on Cockroft-Gault and MDRD Formulas

et al. 2011

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“…Because no prior studies of renal function have been reported under the conditions imposed by this protocol, blinded CrCl data were reviewed prior to analysis for possible outliers. Based on the range of published results of CrCl in normal pregnancy and PE, 20,21 aberrant CrCl values were identified for 10 time points in a total of seven subjects (range: 354 to 1082 mL/min). Six (three DIF, three placebo) of these time points were at baseline with short collection times (120 to 240 minutes) and high urine flows (1.75 to 14.4 mL/min), conditions that would promote spuriously high values.…”

Section: Methodsmentioning

confidence: 99%

Digoxin Immune Fab Treatment for Severe Preeclampsia

et al. 2010

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We evaluated the efficacy, safety, and biological mechanisms of digoxin immune Fab (DIF) treatment of severe preeclampsia. Fifty-one severe preeclamptic patients were randomized in double-blind fashion to DIF ( N = 24) or placebo ( N = 27) for 48 hours. Primary outcomes were change in creatinine clearance (CrCl) at 24 to 48 hours and antihypertensive drug use. Serum sodium pump inhibition, a sequela of endogenous digitalis-like factors (EDLF), was also assessed. CrCl in DIF subjects was essentially unchanged from baseline versus a decrease with placebo (-3 +/- 10 and -34 +/- 10 mL/min, respectively, P = 0.02). Antihypertensive use was similar between treatments (46 and 52%, respectively, P = 0.7). Serum sodium pump inhibition was decreased with DIF compared with placebo at 24 hours after treatment initiation (least squares mean difference, 19 percentage points, P = 0.03). DIF appeared to be well tolerated. These results suggest DIF prevents a decline in renal function in severe preeclampsia by neutralizing EDLF. Sodium pump inhibition was significantly improved. Further research is warranted.

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“…Preeclampsia manifests by proteinuria, hypertension, and impaired renal function 83 . Assessment of renal function is important in the evaluation of the pregnant hypertensive patient 1 . Serum Cystatin C seems to reflect glomerular filtration rate reliably in hypertensive pregnant women and avoids the inaccuracy associated with the 24-hour urine collection, which is time consuming and subject to improper collection 1 .To determine the cutoff point of Cystatin C for the detection of renal impairment in hypertensive pregnancies.…”

Section: Copernicus Publishingmentioning

confidence: 99%

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

Viniegra¹,

Shiguetomi²,

Glogauer³

2018

CMRJ

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Cystatin C is a low-molecular-weight biomarker that meets the conditions necessary to be a marker of the glomerular filtration rate. This endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily plays a key role in health and disease. Human cystatin C is encoded by the CST3 gene, ubiquitously expressed at moderate levels throughout the body, given it is produced in all nucleated cells in a constant amount. It is present in all human body fluids, and may be determined in the serum, plasma, capillary blood and urine. In this review, we present and discuss most of the available data from the literature for the use of cystatin C in clinical practice. In addition to a kidney function marker, studies suggest cystatin C could be used as a marker for cardiovascular risk assessment, in predicting and detecting preeclampsia, in patients with malignant neoformations, etc. Local cystatin C deficiency has also been demonstrated in atherosclerosis, aneurismal lesions, among others, suggesting a protective role of cystatin C. Far beyond its humble beginning, it promises uses from prognosis to treatments for everything from prostate cancer to periodontal disease. Cystatin C has begun its journey into a multitude of disciplines; we can only begin to imagine the many more purposes yet to find going forward.

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Serum Cystatin C for Assessment of Glomerular Filtration Rate in Hypertensive Disorders of Pregnancy

Abstract: Serum cystatin C seems to reflect glomerular filtration rate reliably in hypertensive pregnant women and avoids the inaccuracy associated with the 24-hour urine collection, which is time consuming and subject to improper collection.

Cited by 7 publications

References 24 publications

Pregnancy Reduces the Accuracy of the Estimated Glomerular Filtration Rate Based on Cockroft-Gault and MDRD Formulas

Pregnancy Reduces the Accuracy of the Estimated Glomerular Filtration Rate Based on Cockroft-Gault and MDRD Formulas

Digoxin Immune Fab Treatment for Severe Preeclampsia

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

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