Serum cystatin C is increased in acute spinal cord injury: a multicentre retrospective study

Zhang, Jinyuan; Ding, Ruoting; Xian, QingZhang; Wang, ZhiKun; Liu, Zhongyuan; Yang, Jincheng; Chen, Jianting

doi:10.1038/s41393-019-0360-7

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…In addition, OPN was higher at T1 compared to T4. Increased serum cystatin-C was found in SCI patients, with higher levels in the more severely injured individuals [ 32 ]. OPN is routinely expressed by injured tissues [ 33 ] and has a potential neuroprotective role in the inflammatory response to spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Feasibility of a Multimodal Approach to Pain Evaluation in Early Stages after Spinal Cord Injury

Capossela

Landmann

Ernst

et al. 2023

IJMS

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This research evaluates the feasibility of a multimodal pain assessment protocol during rehabilitation following spinal cord injury (SCI). The protocol amalgamates clinical workup (CW), quantitative sensory testing (QST), and psychosocial factors (PSF) administered at 4 (T1), 12 (T2), and 24 (T3) weeks post injury and at discharge (T4). Molecular blood biomarkers (BB) were evaluated via gene expression and proteomic assays at T1 and T4. Different pain trajectories and temporal changes were identified using QST, with inflammation and pain-related biomarkers recorded. Higher concentrations of osteopontin and cystatin-C were found in SCI patients compared to healthy controls, indicating their potential as biomarkers. We observed altered inflammatory responses and a slight increase in ICAM-1 and CCL3 were noted, pointing towards changes in cellular adhesion linked with spinal injury and a possible connection with neuropathic pain. Despite a small patient sample hindering the correlation of feasibility data, descriptive statistical analyses were conducted on stress, depression, anxiety, quality of life, and pain interferences. The SCI Pain Instrument (SCIPI) was efficient in distinguishing between nociceptive and neuropathic pain, showing a progressive increase in severity over time. The findings emphasize the need for the careful consideration of recruitment setting and protocol adjustments to enhance the feasibility of multimodal pain evaluation studies post SCI. They also shed light on potential early adaptive mechanisms in SCI pathophysiology, warranting the further exploration of prognostic and preventive strategies for chronic pain in the SCI population.

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Section: Discussionmentioning

confidence: 99%

Assessing the Feasibility of a Multimodal Approach to Pain Evaluation in Early Stages after Spinal Cord Injury

Capossela

Landmann

Ernst

et al. 2023

IJMS

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“…One study found that concentration of cystatin C in cerebrospinal fluid would increase in TBI patients [47]. Increase of serum cystatin C was also observed in patients suffering acute spinal cord injury [48]. Actually, increased production of cystatin C was an auto neural-protective response to protease hyperactivation in brain tissue and was beneficial for blood-brain barrier integrity and attenuation of early brain injury [47,[49][50][51].…”

Section: Discussionmentioning

confidence: 99%

A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury

Wang

Gui

et al. 2021

Renal Failure

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Background Acute kidney injury (AKI) is a common complication in traumatic brain injury (TBI) patients and is associated with unfavorable outcome of these patients. We designed this study to explore the value of serum cystatin C, an indicator of renal function, on predicting AKI after suffering TBI. Methods Patients confirmed with TBI and hospitalized in the West China Hospital of Sichuan University between January 2015 and December 2019 were included. Patients were divided into two groups according to occurrence of AKI. Univariate and multivariate logistic regression analyses were sequentially utilized to find risk factors of AKI in included TBI patients. Nomogram composed of discovered risk factors for predicting AKI was constructed. Receiver operating characteristics (ROC) curves were drawn and area under the ROC curve (AUC) were calculated to evaluate the predictive value of cystatin C alone and the constructed nomogram. Results Among 234 included TBI patients, 55 were divided into AKI group. AKI group had shorter length of stay ( p < 0.001) and higher in-hospital mortality ( p < 0.001). Multivariate logistic regression analysis showed absolute lymphocyte count ( p = 0.034), serum creatinine ( p < 0.001), serum cystatin C ( p = 0.017) and transfusion of red blood cell ( p = 0.005) were independently associated with development of AKI after TBI. While hypertonic saline use was not associated with the development of AKI ( p = 0.067). The AUC of single cystatin C and predictive nomogram were 0.804 and 0.925, respectively. Conclusion Higher serum cystatin C is associated with development of AKI in TBI patients. Predictive nomogram incorporating cystatin C is beneficial for physicians to evaluate possibilities of AKI and consequently adjust treatment strategies to avoid occurrence of AKI.

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“…Zhang et al showed that CysC levels are increased in patients with acute SCI, possibly as a direct result of the injury. Serum CysC is a potential biomarker of SCI [31].…”

Section: Cystatin C (Cst3)mentioning

confidence: 99%

Identification of acute spinal cord injury and autophagy-related potential key genes，pathways, and targeting drugs through bioinformatics analysis

Xu¹,

Zhao²

2021

Preprint

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Background: Acute spinal cord injury (ASCI) is considered a form of severe central nervous system damage. At present, research in the fields of spinal surgery and neurology has highlighted the complex mechanisms underlying ASCI, among which autophagy is considered to play a crucial role.Objectives: We aimed to identify the genes and molecular pathways associated with ASCI and autophagy using computational tools and publicly available data, and to identify drugs targeting the relevant genes associated with ASCI and autophagy.Materials and Methods: We used text mining to detect the ASCI and autophagy-associated genes, and the intersection of the two gene sets was selected for gene ontology analysis using the DAVID program. We then constructed protein–protein interaction networks, followed by a functional enrichment analysis, from which we obtained two significant gene modules. Finally, the final list of genes was queried against the Drug Gene Interaction database to find drug candidates targeting the relevant ASCI and autophagy genes.Results: Our analysis identified 156 genes common to both the “ASCI” and “Autophagy” text mining concepts. Gene enrichment analysis yielded two significant gene modules (20 genes), which represent six significant signal pathways and could be targeted by 28 Food and Drug Administration (FDA)-approved drug molecules, and identified the drug–gene interactions. Conclusion: In conclusion, we presented a method to explore the potential key genes, molecular pathways and candidate drugs associated with ASCI and autophagy. As a result, in this method, we identified a total of 20 potential genes, six significant pathways and 28 candidate drugs, which could provides a basis for new trials and the development of novel targeted therapies as potential treatments for ASCI.

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Serum cystatin C is increased in acute spinal cord injury: a multicentre retrospective study

Cited by 4 publications

References 24 publications

Assessing the Feasibility of a Multimodal Approach to Pain Evaluation in Early Stages after Spinal Cord Injury

Assessing the Feasibility of a Multimodal Approach to Pain Evaluation in Early Stages after Spinal Cord Injury

A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury

Identification of acute spinal cord injury and autophagy-related potential key genes，pathways, and targeting drugs through bioinformatics analysis

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