Serum cystatin C measurement in differential diagnosis of intra and extrahepatic cholestatic diseases

Büyükberber, Mehmet; Koruk, İrfan; Cýkman, Oztekin; Koruk, Mehmet; Küçükoğlu, Mehmet Emin; Sakman, Abdullah; Demir, Omer; Şahinöz, Saime

doi:10.1016/s1665-2681(19)31680-1

Cited by 4 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, Cys C, a potent inhibitor of cysteine proteinases, may participate in the development of fibrosis by inactivating cathepsins, which may be related to the progression of hepatic diseases [ 31 ]. Further, serum Cys C concentrations in the intrahepatic cholestasis patients were found significantly elevated than in the controls [ 32 ]. Thus, Cys C may act as a sensitive marker in monitoring liver function during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Establishment of trimester-specific reference intervals of renal function tests and their predictive values in pregnant complications and perinatal outcomes: A population-based cohort study

Han,

Liu,

Meng

et al. 2023

Practical Laboratory Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Establishment of trimester-specific reference intervals of renal function tests and their predictive values in pregnant complications and perinatal outcomes: A population-based cohort study

Han,

Liu,

Meng

et al. 2023

Practical Laboratory Medicine

View full text Add to dashboard Cite

“…The nearer the levels of Cyst-C in control group and in patients without renal impairment, and absence of association between Cyst-C and the etiology of liver disease, reflects that the variations of Cyst-C levels occurred most likely according to the severity of renal impairment, rather than severity of the hepatic condition. This was in accordance with a study done by Buyukberber et al ., which may add to the accuracy of Cyst-C in detecting kidney function [ 12 ]. In agreement with that, Orlando et al .…”

Section: Discussionmentioning

confidence: 99%

Elevated cystatin C: is it a reflection for kidney or liver impairment in hepatic children?

El-Sayed

El-Araby

Adawy

et al. 2017

ceh

View full text Add to dashboard Cite

Aim of the studyTo assess if elevated serum cystatin C (Cyst-C) is an indicator for renal or hepatic dysfunction in presence of liver fibrosis.Material and methodsData of 50 children with chronic liver diseases (CLDs), out of which 25 were without renal impairment, and 25 with renal impairment were analyzed. Twenty healthy children served as a healthy control group. Routine investigations, creatinine clearance, hepatitis viral markers, abdominal ultrasonography, and liver biopsy were performed for patients with CLDs. Measurement of serum Cyst-C concentration by particle induced immunonephelometry were completed for both patients and control group.ResultsResults showed that serum Cyst-C is not correlated with the degree of hepatic impairment (p > 0.05). Cyst-C levels were significantly higher in patients with renal impairment (3.66 ± 0.85) than those without (0.71 ± 0.12), and healthy control group (0.63 ± 0.85). Cystatin-C showed significant elevation in patients with severe fibrosis with renal impairment (3.66 ± 0.85) than those without (0.76 ± 0.04) (p < 0.0001). Cyst-C at cutoff levels of 1.65 mg/l showed 100% accuracy in discrimination between those with and those without renal impairment. Cyst-C > 2.34 mg/l predicting GFR < 40 ml/min with accuracy of 90%. Cyst-C > 2.73 mg/l predicting GFR < 20 ml/min with accuracy of 81.5%.ConclusionsSerum Cyst-C is a promising marker to estimate renal impairment in children with CLDs. Further studies are needed to estimate the accuracy of serum Cyst-C for early detection of renal impairment and close monitoring of the hepatic children.

show abstract

Rat Model Investigation on the Role of Biomarkers in Hepatic Ischemia-Reperfusion Injury

Dogan¹,

Saraç²,

Degerli³

et al. 2021

Exp Clin Transplant

View full text Add to dashboard Cite

Serum cystatin C measurement in differential diagnosis of intra and extrahepatic cholestatic diseases

Cited by 4 publications

References 14 publications

Establishment of trimester-specific reference intervals of renal function tests and their predictive values in pregnant complications and perinatal outcomes: A population-based cohort study

Establishment of trimester-specific reference intervals of renal function tests and their predictive values in pregnant complications and perinatal outcomes: A population-based cohort study

Elevated cystatin C: is it a reflection for kidney or liver impairment in hepatic children?

Rat Model Investigation on the Role of Biomarkers in Hepatic Ischemia-Reperfusion Injury

Contact Info

Product

Resources

About