Serum cytokines and anxiety in adolescent depression patients: Gender effect

Pallavi, Pooja; Sagar, Rajesh; Mehta, Manju; Sharma, Swati; Subramanium, Arulselvi; Shamshi, Farah; Sengupta, Utpal; Pandey, Ravindra M.; Mukhopadhyay, Ayan

doi:10.1016/j.psychres.2015.06.036

Cited by 61 publications

(71 citation statements)

References 40 publications

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“…CIPN has been associated with pro-inflammatory states such as upregulation of pro-inflammatory cytokines [32, 33] and anxiety, depression, and sleep disturbance have all been associated with elevated levels of pro-inflammatory cytokines[34–37]. Obesity has also been associated with elevated pro-inflammatory cytokines[38].…”

Section: Discussionmentioning

confidence: 99%

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Bao

Basal

Seluzicki

et al. 2016

Breast Cancer Res Treat

268

224

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Purpose CIPN is a common toxicity associated with chemotherapy, but researchers rarely study its risk factors, fall risk, and prevalence in long-term breast cancer survivors. We aimed to determine CIPN prevalence, risk factors, and association with psychological distress and falls among long-term breast cancer survivors. Methods We conducted cross-sectional analyses among postmenopausal women with a history of stage I–III breast cancer who received taxane-based chemotherapy. Participants reported neuropathic symptoms of tingling/numbness in hands and/or feet on a 0–10 numerical rating scale. We conducted multivariate logistic regression analyses to evaluate risk factors associated with the presence of CIPN and the relationship between CIPN and anxiety, depression, insomnia, and patient-reported falls. Results Among 296 participants, 173 (58.4%) reported CIPN symptoms, 91 (30.7%) rated their symptoms as mild and 82 (27.7%) rated them moderate to severe. Compared with women of normal weight, being obese was associated with increased risk of CIPN, (adjusted OR 1.94, 95% CI: 1.03–3.65). Patients with CIPN reported greater insomnia severity, anxiety, and depression than those without (all p<0.05). Severity of CIPN was associated with higher rates of falls, with 23.8%, 31.9%, and 41.5% in the “no CIPN,” “mild,” and “moderate-to-severe” groups, respectively, experiencing falls (p=0.028). Conclusions The majority of long-term breast cancer survivors who received taxane-based chemotherapy reported CIPN symptoms; obesity was a significant risk factor. Those with CIPN also reported increased psychological distress and falls. Interventions need to target CIPN and comorbid psychological symptoms, and incorporate fall prevention strategies for aging breast cancer survivors.

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Section: Discussionmentioning

confidence: 99%

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Bao

Basal

Seluzicki

et al. 2016

Breast Cancer Res Treat

268

224

View full text Add to dashboard Cite

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“…For example, acetaminophen clearance was 22% higher in men than in women; interestingly, women using oral contraceptives use had a 49% higher clearance than control women, which made their clearance rates even higher than males [247]. [277], Women [276] Anxiety IL-1β + correlation Women only [267] IL-10 + correlation Women only [267] IL-17 −correlation Women only [267] TGF-β1 −correlation Men and women [267] Aspirin has a higher bioavailability in women than in men, and oral contraceptives reverse these metabolic sex differences [248].…”

Section: Cyclooxygenase (Cox) Inhibitors and Non-steroidal Anti-inflamentioning

confidence: 99%

Inflaming sex differences in mood disorders

Rainville

Hodes

2018

Neuropsychopharmacol

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Men and women often experience different symptoms or rates of occurrence for a variety of mood disorders. Many of the symptoms of mood disorders overlap with autoimmune disorders, which also have a higher prevalence in women. There is a growing interest in exploring the immune system to provide biomarkers for diagnosis of mood disorders, along with new targets for developing treatments. This review examines known sex differences in the immune system and their relationship to mood disorders. We focus on immune alterations associated with unipolar depression, bipolar depression, and anxiety disorders. We describe work from both basic and clinical research examining potential immune mechanisms thought to contribute to stress susceptibility and associated mood disorders. We propose that sex and age are important, intertwined factors that need to be included in future experimental designs if we are going to harness the power of the immune system to develop a new wave of treatments for mood disorders.

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“…GDNF is also resistant to repeated freeze/thaw cycles (204). Plasma GDNF concentrations have been associated with mood state, bipolar disorder and age [increased (205)], late-life depression [reduced (206)], adolescent depression [decreased (207)], attention deficit [increased (208)]. …”

Section: Pre-analytical Factorsmentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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Serum cytokines and anxiety in adolescent depression patients: Gender effect

Cited by 61 publications

References 40 publications

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk

Inflaming sex differences in mood disorders

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

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