Serum endostatin levels in patients with hepatocellular carcinoma

Yamagata, M; Shiratori, Yoshimune; Dan, Yoshiyuki; Shiina, S.; Takayama, T; Makuuchi, Masatoshi; Omata, Masao

doi:10.1023/a:1008318526938

Cited by 26 publications

(24 citation statements)

References 6 publications

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“…The generation of endostatin or collagen XVIII by human tumors appears to depend on tumor histology. Some reports have demonstrated that endostatin serum levels are elevated in patients with breast cancer, bladder cancer, renal cell carcinoma, endometrial cancer, and soft tissue sarcoma (12,(23)(24)(25)(26), whereas other investigators have reported circulating endostatin levels similar to those in healthy controls in patients with head and neck squamous cell carcinoma (27), squamous cell vulvar carcinoma (28), and hepatocellular carcinoma (29). We have previously demonstrated that serum endostatin levels are elevated in patients with NSCLC (14).…”

Section: Discussionmentioning

confidence: 74%

Overexpression of Collagen XVIII Is Associated with Poor Outcome and Elevated Levels of Circulating Serum Endostatin in Non–Small Cell Lung Cancer

Iwamoto

Chang

Suzuki

et al. 2004

Clinical Cancer Research

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Purpose: The aim of this study was to determine whether collagen XVIII expression is correlated with circulating serum endostatin and whether this has any prognostic value in patients with non-small cell lung cancer (NSCLC).Experimental Design: Serum endostatin levels were measured quantitatively by a competitive enzyme immunoassay, and collagen XVIII expression in tumor tissue was investigated with an immunohistochemical method in a series of 94 patients who underwent surgery for NSCLC.Results: Sixty cases (63.8%) had positive immunohistochemical staining with anticollagen XVIII polyclonal antibodies, including strongly positive staining in 11 (11.7%) cases. The mean (؎ SD) serum endostatin level was 41.6 ؎ 34.4 ng/ml in the patient group and 16.3 ؎ 10.3 ng/ml in the control group (P < 0.0001). The 11 cases who were strongly collagen XVIII-positive had significantly higher serum endostatin levels than the cases who were negative or weakly positive (P ‫؍‬ 0.0297). The 5-year survival rates of negative, weakly positive, and strongly positive patients were 77.8%, 56.9%, and 43.8%, respectively. The cases with strongly positive collagen XVIII expression had a significantly poorer outcome than cases with negative expression (P ‫؍‬ 0.0027). A multivariate analysis with Cox proportional hazards model for disease-specific survival revealed that expression of collagen XVIII (strongly positive versus negative; weakly positive versus negative), tumor classification, and regional lymph node classification were independent prognostic factors.Conclusions: Our results suggest that expression of collagen XVIII in tumor tissue is strongly associated with a poorer outcome in NSCLC and correlates with elevated levels of circulating serum endostatin.

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Section: Discussionmentioning

confidence: 74%

Overexpression of Collagen XVIII Is Associated with Poor Outcome and Elevated Levels of Circulating Serum Endostatin in Non–Small Cell Lung Cancer

Iwamoto

Chang

Suzuki

et al. 2004

Clinical Cancer Research

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“…Two recent studies have evaluated the clinical significance of serum endostatin in patients with HCC 28,29 . One found that serum endostatin levels were not significantly increased in patients with HCC compared with healthy controls and that levels did not correlate with tumour stage 28 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma

Poon

Tong

et al. 2004

British Journal of Surgery

207

126

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“…10,11 The role of endostatin/C18 expression during liver cirrhosis or HCC progression remains controversial despite previous studies. [12][13][14][15] In the present study, we analyzed endostatin/C18 expression in HCC cell lines as well as clinical specimens, thereby to delineate the involvement of endostatin/C18 expression in liver carcinogenesis.…”

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confidence: 99%

Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma

Huang

et al. 2005

Modern Pathology

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Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains elusive. Therefore, we studied its expression in five hepatoma cell lines and 105 hepatocellular carcinoma specimens. The poorly differentiated hepatoma cell lines exhibited increased endostatin/collagen XVIII levels compared with the well-differentiated ones. In hepatoma tissues, endostatin/collagen XVIII expression was detected in various types of liver cells and was significantly stronger in adjacent nontumor tissues than that in tumors (Po0.001). Endostatin/collagen XVIII expression in nontumor tissues correlated with tumor stages (P ¼ 0.014) and expression of vascular endothelial growth factor (P ¼ 0.007), but not the stages of hepatic fibrosis (P40.05). Kaplan-Meier analysis showed that patients with higher endostatin/collagen XVIII expression had significantly shorter overall survival (P ¼ 0.011) and disease-free survival (P ¼ 0.0034). Moreover, endostatin/collagen XVIII level was an independent prognostic factor for tumor recurrence (P ¼ 0.034) by multivariate analysis. In conclusion, increased endostatin/collagen XVIII expression correlated with hepatoma progression and predicted poor prognosis for patients with hepatocellular carcinoma.

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Serum endostatin levels in patients with hepatocellular carcinoma

Cited by 26 publications

References 6 publications

Overexpression of Collagen XVIII Is Associated with Poor Outcome and Elevated Levels of Circulating Serum Endostatin in Non–Small Cell Lung Cancer

Overexpression of Collagen XVIII Is Associated with Poor Outcome and Elevated Levels of Circulating Serum Endostatin in Non–Small Cell Lung Cancer

Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma

Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma

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