Serum endothelin-1 and placental alkaline phosphatase levels in placenta percreta and normal pregnancies

Uyanıkoğlu, Hacer; Turp, Ahmet Berkız; Hilali, Neşe Gül; Incebiyik, Adnan

doi:10.1080/14767058.2017.1297412

Cited by 3 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2010 ; Uyanikoglu et al. 2018 ). A highly coordinated action of ET, E 2 , PGF2 and P is required for placental formation, maturation, and separation.…”

Section: Discussionmentioning

confidence: 99%

“…The dysregulation of reproductive hormones and ET is an important incentive to hinder placental maturation and separation (Uyanikoglu et al. 2018 ). In this study, reproductive hormones and ET were most significantly different between healthy cows and cows with RP at 7 days before delivery, demonstrating the close relationship between dysregulation of ET and reproductive hormones and RP in dairy cows.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

Wen

Yang

et al. 2022

Veterinary Quarterly

View full text Add to dashboard Cite

The complex etiopathology of retained placenta (RP) and hazards associated with it has made it crucial for researchers and clinical veterinarians to study pathogenesis, early-warning diagnosis, and treatment. This study aimed to screen the potential prognostic markers of RP in dairy cows using plasma metabolomics coupled with clinical laboratory indicators. Blood samples were collected from 260 dairy cows at 21, 14, 7, and 0 days before parturition and 7, 14, and 21 days after parturition. Consequently, 10 healthy cows and 10 cows with RP with similar parity, body condition score, and age were included in the study. The changes in clinical laboratory indicators of the enrolled cows from 21 before parturition to 21 days after parturition were assessed. After initial overview of the multivariate statistical data using PCA analysis, the data were subjected to orthogonal partial least-squares discriminant analysis. Compared with cows with RP at 7 days before parturition, the levels of endothelin and 6-keto-prostaglandin F1α were increased in healthy cows, while the level of estradiol and progesterone decreased. Adenine dinucleotide phosphate, hypoxanthine, guanine dinucleotide phosphate, inosine monophosphate, and L-arginine were revealed as potential prognostic markers of cows with RP at 7 days before parturition involved in the regulation of taste transduction, purine and glutathione metabolism, and autophagy. The best period for the early-warning diagnosis of RP in dairy cows is 7 days before parturition, and purine metabolism and autophagy may play a vital role in the occurrence and development of RP in dairy cows.

show abstract

“… 2010 ; Uyanikoglu et al. 2018 ). A highly coordinated action of ET, E 2 , PGF2 and P is required for placental formation, maturation, and separation.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

Wen

Yang

et al. 2022

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…Placenta percreta (PP) is a serious complication of pregnancy characterized by placental hyperinvasion, where the villi penetrate the full thickness of the myometrium, which can cause both fetal and maternal morbidity (unplanned surgery, massive bleeding and resultant disseminated intravascular coagulation, adult respiratory distress syndrome, renal insufficiency, etc.) and mortality (1).…”

Section: Introductionmentioning

confidence: 99%

Shear-wave elastography for detection of placenta percreta: a case-controlled study

Dokumaci

Uyanıkoğlu

2021

Acta Radiol

Self Cite

View full text Add to dashboard Cite

Background Prenatal diagnosis of placenta percreta (PP) is important to be able to provide effective management and a multidisciplinary approach to minimize the complications. Purpose To evaluate the role of shear-wave elastography (SWE) in the prenatal diagnosis of PP. Material and Methods A total of 18 women with PP and 20 pregnant women with normal placenta in the second or third trimesters were included in this prospective study. SWE was used to determine the elasticities of the placenta (in the maternal edge of the placenta) and myometrium. The obstetric data regarding grayscale and Doppler ultrasonography, and perinatal outcomes were reviewed. A mean placental SW velocity (SWV) cut-off value was determined to predict the presence of placental adherence. Results The SWV values of the PP group in the maternal edge of the placenta were significantly higher than those of the control group (1.95 ± 0.19 m/s and 1.69 ± 0.23 m/s; P = 0.001). Myometrial SWV was also higher in the PP group compared to the control group (2.25 ± 0.39 m/s and 1.90 ± 0.71 m/s; P = 0.002). A receiver operating characteristic (ROC) curve analysis was performed and the best cut-off value of placental SWV was determined as 1.92 m/s with sensitivity of 58% and specificity of 80%, to predict the placental adherence in patients with PP. Conclusion Placental stiffness was significantly higher in patients with PP than in pregnant women with normally localized placenta. Thus, we thought that SWE of the placenta might be used as an alternative method in the diagnosis of PP.

show abstract

Serum ischemia modified albumin level and its relationship with the thiol/disulfide balance in placenta percreta patients

Uyanıkoğlu

Sak

Tatlı

et al. 2018

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

The pathogenesis of placenta percreta (PP) is not very well known. This study was designed to analyse the oxidative stress (OS), the thiol/disulphide balance, and ischaemia-modified albumin (IMA) the women with PP. The study included 38 pregnant women with PP and 40 similarly aged healthy pregnant women in their third trimester of gestation. We measured the IMA, native and total thiols, and disulphide concentrations in the maternal sera of all of the participating women. The IMA levels were higher and the native and total thiols were lower in the PP group than in the control group. However, there was no statistical significance with respect to the thiol/disulphide balance between the two groups. The results of this study suggest that an increase in the ischaemia and OS and a decrease in the antioxidant status may contribute to the pathogenesis of PP. Impact statement What is already known on this subject? Placenta percreta (PP) is a serious complication of pregnancy. Although there are several studies investigating the pathophysiological mechanism of PP, whether the pathology results from a lack of decidua or from the over-invasiveness of trophoblasts remains controversial. The pathology of PP is poorly understood. What do the results of this study add? This prospective study has shown an increased ischaemia modified albumin (IMA) and a decreased antioxidant capacity in the patients with placenta percreta. The results from 38 women with PP suggest that the serum concentrations of IMA and the oxidative stress parameters may be able to predict PP in cases of uncertainty. What are the implications of these findings for clinical practice and/or further research? The implication of these findings shed light on understanding the pathogenesis of PP for further research.

show abstract

Serum endothelin-1 and placental alkaline phosphatase levels in placenta percreta and normal pregnancies

Abstract: The findings suggest that a decrease in ET-1 and placental ALP levels might play a role in the pathogenesis of PP.

Cited by 3 publications

References 23 publications

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

Potential prognostic markers of retained placenta in dairy cows identified by plasma metabolomics coupled with clinical laboratory indicators

Shear-wave elastography for detection of placenta percreta: a case-controlled study

Serum ischemia modified albumin level and its relationship with the thiol/disulfide balance in placenta percreta patients

Contact Info

Product

Resources

About