Serum Erythropoietin and Erythropoiesis during Six Years after Kidney Transplantation

Goch, Janusz; Birgegård, Gunnar; Wíkström, Björn; Backman, U.; Wadström, Jonas; Danielson, Bo G.

doi:10.1159/000189475

Cited by 6 publications

(9 citation statements)

References 14 publications

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“…Furthermore, we confirmed that patients with insufficient graft function development had EPO serum concentrations comparable to patients with normal graft function and that the achieved transplanted kidney function had no relation to EPO values. This observation is in accordance with the conclusions of some other authors [17,18] , and does not support isolated finding that EPO serum concentrations are statistically significantly higher in patients with good graft function than in patients with insufficient function of a transplanted kidney [19] .…”

Section: Discussionsupporting

confidence: 55%

Endogenous Erythropoietin Levels and Anemia in Long-Term Renal Transplant Recipients

Zadrazil

Horák

Horčička

et al. 2007

Kidney Blood Press Res

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Background/Aim: Although anemia is a common complication after renal transplantation (RT), data concerning endogenous erythropoietin (EPO) levels in long-term RT recipients are rare. The goal of this study was to evaluate the prevalence of anemia within 6 months to 5 years after RT and to assess the relationship between the serum concentrations of endogenous EPO, graft function and grade of improvement of anemia. Methods: 140 patients who had undergone RT were included in the group: 89 males (63.6%) and 51 females (36.4%), with an average age 46.8 ± 12.8 years. The serum concentrations of EPO and creatinine (Cr) were tested in all the individuals and the values of the red blood component of blood count, serum ferritin (SF), plasma iron concentration, plasma total iron-binding capacity (TIBC), transferrin saturation (TS), folic acid and vitamin B₁₂ levels in the serum were determined. A statistical analysis of the results was performed using the correlation analysis, Mann-Whitney U test and Duncan’s multiple range test. Results: Normal blood count values were found in 91 patients (65%), and a mild grade of anemia with a mean hemoglobin (Hb) 114.4 ± 11.9 g/l was observed in 45 patients (32.1%), and 4 patients (2.9%) fulfilled the diagnostic criteria for post-transplantation erythrocytosis. Individuals with normal Hb values had a mean EPO serum concentration of 39.3 ± 12.3 mU/ml (median 37.2) and the mean Cr was 133.8 ± 36.9 µmol/l (median 122). Patients with anemia (Hb <120 g/l in females, Hb <130 g/l in males) had a mean EPO value of 47.0 ± 26.6 mU/ml (median 36.0) and a mean Cr of 203.8 ± 108.9 µmol/l (median 181). The difference in the Cr values was statistically significant (p < 0.0001), while the difference between the EPO concentrations was not significant. No relation of EPO serum concentration with regard to graft function was found in the analysis. A lack of storage iron (SF <10 µg/l in females, SF <22 µg/l in males) was found in 16 patients (11.4%), and a lack of functional iron (TS <20%) was found in 27 patients (19.3%). Conclusions: Theprevalence of anemia in patients after transplantation was 32.1%. The most common cause of anemia is insufficient graft function development. The achieved values of the red component of blood count have no relation to the endogenous EPO serum concentrations.

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Section: Discussionsupporting

confidence: 55%

Endogenous Erythropoietin Levels and Anemia in Long-Term Renal Transplant Recipients

Zadrazil

Horák

Horčička

et al. 2007

Kidney Blood Press Res

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“…While a number of genome-wide association studies (GWAS) could link RBC traits such as RBC size, hemoglobin (Hb) content and hematocrit levels to single-nucleotide polymorphisms (SNP), only few studies analyzed circulating Epo levels. Some specific studies focused on aging populations with gradually decreasing renal function, 1 Epo levels after kidney transplantation, 2 or the (lack of) sex-specific differences in chronically anemic patients. 3 However, none of these initial analyses have been performed in a population-based cohort which would have the advantage of a high external validity of the findings.…”

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confidence: 99%

Heritability and association with distinct genetic loci of erythropoietin levels in the general population

et al. 2021

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“…One study focused on ageing populations with gradually decreasing renal function [ 9 ]. Some smaller studies looked at Epo after kidney transplantation [ 39 , 40 ], or at the (lack of) sex-specific differences in chronically anemic patients [ 51 ]. None of these initial analyses has been performed in a larger cohort of randomly chosen, healthy individuals of the normal population.…”

Section: Genetics To Provide More Insights Into Epo Regulation?mentioning

confidence: 99%

Fount, fate, features, and function of renal erythropoietin-producing cells

Dahl

Bapst

Khodo

et al. 2022

Pflugers Arch - Eur J Physiol

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Renal erythropoietin (Epo)-producing (REP) cells represent a rare and incompletely understood cell type. REP cells are fibroblast-like cells located in close proximity to blood vessels and tubules of the corticomedullary border region. Epo mRNA in REP cells is produced in a pronounced “on–off” mode, showing transient transcriptional bursts upon exposure to hypoxia. In contrast to “ordinary” fibroblasts, REP cells do not proliferate ex vivo, cease to produce Epo, and lose their identity following immortalization and prolonged in vitro culture, consistent with the loss of Epo production following REP cell proliferation during tissue remodelling in chronic kidney disease. Because Epo protein is usually not detectable in kidney tissue, and Epo mRNA is only transiently induced under hypoxic conditions, transgenic mouse models have been developed to permanently label REP cell precursors, active Epo producers, and inactive descendants. Future single-cell analyses of the renal stromal compartment will identify novel characteristic markers of tagged REP cells, which will provide novel insights into the regulation of Epo expression in this unique cell type.

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Serum Erythropoietin and Erythropoiesis during Six Years after Kidney Transplantation

Cited by 6 publications

References 14 publications

Endogenous Erythropoietin Levels and Anemia in Long-Term Renal Transplant Recipients

Endogenous Erythropoietin Levels and Anemia in Long-Term Renal Transplant Recipients

Heritability and association with distinct genetic loci of erythropoietin levels in the general population

Fount, fate, features, and function of renal erythropoietin-producing cells

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