Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis

Li, Luqian; Xiao, Fei; Guo-lian, Liu; Chen, Yufeng

doi:10.1155/2022/9501008

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…MiR-30a targeted and inhibited FAP expression, thus resulting in the suppression of oral cancer or gastric cancer [ 28 , 29 ]. AC007099.1/has-miR-7152/FAP axis was associated with LIHC progression [ 30 ]. SNHG16/hsa-miRNA-30c-5p/FAP axis was constructed in STAD, however, neither significant association between FAP and SNHG16, nor prolonged survival of SNHG16 was observed [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers

Mai

Liu

et al. 2023

Aging

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Fibroblast activation protein-alpha (FAP) is a transmembrane serine protease involving in tissue remodeling. Previous studies report that FAP is highly expressed in certain tumors and participated in oncogenesis. However, there is still lack of systematic and in-depth analysis of FAP based on clinical big data. Here, we comprehensively map the FAP expression profile, prognostic outcome, genetic alteration, immune infiltration across over 30 types of human cancers through multiple datasets including TCGA, CPTAC, and cBioPortal. We find that FAP is up-regulated in most cancer types, and increased FAP expression is associated with advanced pathological stages or poor prognosis in several cancers. Furthermore, FAP is significantly correlated with the infiltration of cancer-associated fibroblasts, macrophages, myeloid dendritic cells, as well as endothelia cells. Immunosuppressive checkpoint proteins or cytokines expression, microsatellite instability and tumor mutational burden analysis also indicate the regulation role of FAP in tumor progression. Gene enrichment analysis demonstrates that ECM-receptor interaction as well as extracellular matrix and structure process are linked to the potential mechanism of FAP in tumor pathogenesis. The ceRNA network is also constructed and identified the involvement of LINC00707/hsa-miR-30e-5p/FAP, LINC02535/hsa-miR-30e-5p/FAP, LINC02535/hsa-miR-30d-5p/FAP, as well as AC026356.1/hsa-miR-30d-5p/FAP axis in tumor progression. In conclusion, our study offers new insights into the oncogenic and immunological role of FAP from a pan-cancer perspective, providing new clues for developing novel targeted anti-tumor strategies.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers

Mai

Liu

et al. 2023

Aging

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“…For all target genes, the clusterProfiler (Version 4.0.5) package and org. Hs.eg.db (Version 3.13.0) package were used to perform GO and KEGG enrichment analyses, retaining all enriched entries with FDR <0.05 as in previous research studies ( Fabris et al, 2020 ; Huang et al, 2021 ; Li et al, 2022a ; Zhang et al, 2022a ; Zhang et al, 2022b ; Wang et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

Wang

Liu

et al. 2022

Front. Genet.

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To determine the relationship between glioma and muscle aging and to predict prognosis by screening for co-expressed genes, this study examined the relationship between glioma and sarcopenia. The study identified eight co-downregulated miRNAs, three co-upregulated miRNAs, and seven genes associated with overall glioma survival, namely, KRAS, IFNB1, ALCAM, ERBB2, STAT3, FOSL1, and EN2. With a multi-factor Cox regression model incorporating FOSL1 and EN2, we obtained ROC curves of 0.702 and 0.709, respectively, suggesting that glioma prognosis can be predicted by FOSL1 and EN2, which are differentially expressed in both cancer and aged muscle. FOSL1 and EN2 were analyzed using Gene Set Enrichment Analysis to identify possible functional pathways. RT-qPCR and a dual-luciferase reporter gene system verified that hsa-miR-33a targets FOSL1 and EN2. We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction.

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“…The overexpression of FAP was correlated with poor prognosis of multiple cancer types, such as pancreatic (Cohen et al, 2008), ovarian (Nepomnyashchikh et al, 2011), and hepatocellular (Ju et al, 2009). In HCC, the level of FAP expression significantly affected the overall survival, progress free interval, and disease specific survival of HCC patients, and high FAP expression was associated with poor prognosis of HCC patients (L. Li et al, 2022), which was consistent with our results that the patients with inversely correlated with the FAP expression (Lyu et al, 2022). We also found the FAP expression was positively associated with the levels of CD8 + T cell, CD4 + T cell, macrophage, neutrophil, dendritic cell, and B cell.…”

Section: Fap Overexpression In Cafs Promoted Proliferation and Migrat...mentioning

confidence: 99%

Fibroblast activation protein promotes progression of hepatocellular carcinoma via regulating the immunity

Wang,

Niu,

Yang

et al. 2024

Cell Biology International

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Fibroblast activation protein (FAP) has been indicated to express in cancer‐associated fibroblasts (CAFs) in most cancers. This work was dedicated to exploring FAP's effects on hepatocellular carcinoma (HCC). The data were extracted from The Cancer Genome Atlas, Gene Expression Omnibus, ImmPort, and Reactome databases. The correlation between FAP and HCC patients' prognosis was explored via survival analysis. The qRT‐PCR and western blot analysis were used to analyze the FAP mRNA and protein expression levels, respectively. The cell proliferation and apoptosis were determined using the cell counting kit‐8 assay kit and Annexin V‐FITC/PI apoptosis kit, respectively. The HCC patients with FAP overexpression displayed a worse prognosis. The FAP expression was positively associated with the infiltration levels of tumor purity, B cell, CD8 + T cell, CD4 + T cell, macrophage, neutrophil, and dendritic cell. The optimal nine immune related genes were screened between two groups (FAP high vs. low). Moreover, we identified 24 energy metabolism related genes (FAP high vs. low) and these 24 genes were highly expressed in the high FAP expression group. The FAP expression had a significant positive correlation with the expression of PD‐1, CTLA4, PDL‐1, and PDL‐2. The FAP overexpression promoted proliferation and migration while inhibiting the apoptosis of HCC cells. The FAP overexpression promoted the progression of HCC by regulating the immunity to affect the prognosis of HCC patients, thereby serving as a poor prognostic marker for HCC patients.

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Serum Exosomal lncRNA AC007099.1 Regulates the Expression of Neuropeptide-Related FAP, as a Potential Biomarker for Hepatocarcinogenesis

Cited by 4 publications

References 41 publications

Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers

Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

Fibroblast activation protein promotes progression of hepatocellular carcinoma via regulating the immunity

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