Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration

Barlow, Peter G.; Donaldson, Ken; MacCallum, J.; Clouter, Anna; Stone, Vicki

doi:10.1016/j.toxlet.2004.11.006

Cited by 65 publications

(28 citation statements)

References 11 publications

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“…Kashiwada (2006) showed a particle-size effect on the accumulation of fluorescent NPs in the Japanese medaka, with the smaller particles accumulating more quickly. Alternatively, studies on mammalian immune cells show no difference in toxicity of ultrafine carbon dust compared to much smaller carbon NPs (Barlow et al 2005). There are also reports of differences in the acute toxicity of dispersed NPs compared to larger aggregates of the same material in invertebrates (Lovern and Klaper 2006; Table 3).…”

Section: Dispersion Of Nanoparticlesmentioning

confidence: 99%

“…So, for example, carbon fullerene NPs (C 60 particles), may have a different toxicity compared to fine (lm sized) graphite particles, even though both particles are made of carbon (Barlow et al 2005). In particular NPs possess a much higher specific surface area (SSA) than their larger counterparts of the same material, and the proportion of atoms on the surface versus the interior of the particle is also much larger for NPs.…”

Section: Defining Nanomaterials In An Ecotoxicological Contextmentioning

confidence: 99%

“…There is at least some speculation that the ability of NPs to generate reactive oxygen species (ROS) at the surface of the NPs, when adjacent to cell membranes, might initiate inflammation reactions or immune responses (Barlow et al 2005). Oxidative stress has been reported in the tissues of aquatic organisms during NP exposure (CNT, Smith et al 2007; TiO 2 Federici et al 2007).…”

Section: Dispersion Of Nanoparticlesmentioning

confidence: 99%

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The ecotoxicology and chemistry of manufactured nanoparticles

et al. 2008

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The emerging literature on the ecotoxicity of nanoparticles and nanomaterials is summarised, then the fundamental physico-chemistry that governs particle behaviour is explained in an ecotoxicological context. Techniques for measuring nanoparticles in various biological and chemical matrices are also outlined. The emerging ecotoxicological literature shows toxic effects on fish and invertebrates, often at low mg l(-1) concentrations of nanoparticles. However, data on bacteria, plants, and terrestrial species are particularly lacking at present. Initial data suggest that at least some manufactured nanoparticles may interact with other contaminants, influencing their ecotoxicity. Particle behaviour is influenced by particle size, shape, surface charge, and the presence of other materials in the environment. Nanoparticles tend to aggregate in hard water and seawater, and are greatly influenced by the specific type of organic matter or other natural particles (colloids) present in freshwater. The state of dispersion will alter ecotoxicity, but many abiotic factors that influence this, such as pH, salinity, and the presence of organic matter remain to be systematically investigated as part of ecotoxicological studies. Concentrations of manufactured nanoparticles have rarely been measured in the environment to date. Various techniques are available to characterise nanoparticles for exposure and dosimetry, although each of these methods has advantages and disadvantages for the ecotoxicologist. We conclude with a consideration of implications for environmental risk assessment of manufactured nanoparticles.

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Section: Dispersion Of Nanoparticlesmentioning

confidence: 99%

Section: Defining Nanomaterials In An Ecotoxicological Contextmentioning

confidence: 99%

Section: Dispersion Of Nanoparticlesmentioning

confidence: 99%

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The ecotoxicology and chemistry of manufactured nanoparticles

et al. 2008

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“…This study also showed that nanoparticle instillation significantly increased macrophage sensitivity to migrate towards the chemoattractant C5a. Barlow et al (2005a) found that blood serum exposed to nanoparticle carbon black showed an increased potential to induce macrophage chemotaxis. Renwick et al (2001) demonstrated that exposure to high concentrations of nanoparticles of TiO 2 and carbon black in vitro, could impair the phagocytic ability of a macrophage cell line.…”

Section: Introductionmentioning

confidence: 99%

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure

et al. 2007

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Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the lung is still unknown, but studies have focused on inhibition of macrophage function and impaired alveolar clearance mechanisms. To assess the effects of PM10 on pulmonary macrophage clearance mechanisms ex vivo, Wistar rats were instilled with 125 or 250 microg of PM10 collected from the North Kensington, London. Control rats were instilled with sterile saline. The rats were sacrificed after 18 h and a bronchoalveolar lavage (BAL) was performed. Macrophages isolated from the BAL fluid were assessed for ability to migrate towards a positive chemoattractant (ZAS) ex vivo and to perform phagocytosis. Macrophages isolated from the PM10-exposed rats showed inhibition of potential to migrate. Macrophage phagocytic ability ex vivo was also significantly reduced by the presence of PM10 inside the cells. This study indicates that acute PM10 exposure diminishes macrophage motility and phagocytosis in a manner that could prove deleterious to particle clearance from the alveolar region of the lung. Decreased particle clearance promotes inflammation, and hence, warrants further investigation in relation to the effects of chronic PM10 exposure on macrophage clearance mechanisms and establishing the mechanisms behind decreased macrophage migration.

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“…Various NP toxicity testing methods have been studied, including general toxicity testing (Oberdorster et al 2005a;Crane et al 2008;Tsuji et al 2006), assessment of toxicokinetics of NP in animal models and humans (Oberdorster et al 2005c), as well as in vitro (Cui et al 2005;Barlow et al 2005;Shvedova et al 2003) and in vivo (Lam et al 2004;Muller et al 2006) assays. Research has been conducted to assess the potential impact of particle size, size distribution, shape, surface area, state of dispersion and surface chemistry on toxicity (Powers et al 2006;Handy et al 2008;Powers et al 2007;Murdock et al 2008;Crane et al 2008;Burello and Worth 2011b).…”

Section: Introductionmentioning

confidence: 99%

Principal component and causal analysis of structural and acutein vitrotoxicity data for nanoparticles

Wang

Yang

et al. 2013

Nanotoxicology

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Structure toxicity relationship analysis was conducted using principal component analysis (PCA) for a panel of nanoparticles that included dry powders of oxides of titanium, zinc, cerium and silicon, dry powders of silvers, suspensions of polystyrene latex beads, and dry particles of carbon black, nanotubes and fullerene, as well as diesel exhaust particles. Acute in vitro toxicity was assessed by different measures of cell viability, apoptosis and necrosis, haemolytic effects and the impact on cell morphology, while structural properties were characterised by particle size and size distribution, surface area, morphology, metal content, reactivity, free radical generation and zeta potential. Different acute toxicity measures were processed using PCA that classified the particles and identified four materials with an acute toxicity profile: zinc oxide, polystyrene latex amine, nanotubes and nickel oxide. PCA and contribution plot analysis then focused on identifying the structural properties that could determine the acute cytotoxicity of these four materials. It was found that metal content was an explanatory variable for acute toxicity associated with zinc oxide and nickel oxide, whilst high aspect ratio appeared the most important feature in nanotubes.Particle charge was considered as a determinant for high toxicity of polystyrene latex amine.

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Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration

Cited by 65 publications

References 11 publications

The ecotoxicology and chemistry of manufactured nanoparticles

The ecotoxicology and chemistry of manufactured nanoparticles

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure

Principal component and causal analysis of structural and acutein vitrotoxicity data for nanoparticles

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