Serum Ferritin: A Predictor of Early Spontaneous Preterm Delivery

Tamura, Tsunenobu; Goldenberg, Robert L.; Johnston, Kelley E.; Cliver, Suzanne P.; Hickey, Carol A.

doi:10.1016/0029-7844(95)00437-8

Cited by 100 publications

(67 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some investigators reported a negative association between maternal serum ferritin and birth weight and a positive association with preterm delivery (23)(24)(25). These findings probably indicate the presence of infection, which elevates serum ferritin.…”

Section: Maternal Anemia and Birth Weightmentioning

confidence: 80%

Anemia and iron deficiency: effects on pregnancy outcome

Allen

2000

The American Journal of Clinical Nutrition

900

660

View full text Add to dashboard Cite

Section: Maternal Anemia and Birth Weightmentioning

confidence: 80%

Anemia and iron deficiency: effects on pregnancy outcome

Allen

2000

The American Journal of Clinical Nutrition

900

660

View full text Add to dashboard Cite

“…92 Eleven studies evaluated more than one test. 22,25,26,34,35,38,50,54,55,58,59 One study reported on both inflammation-and coagulation-related biomarkers. 58 The median number of studies per biomarker was two (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14] post-test probability of preterm birth ¼ likelihood ratio Â pre-test probability ½1 À pre-test probability Â ð1 À likelihood ratioÞ:…”

Section: Resultsmentioning

confidence: 99%

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

147

114

View full text Add to dashboard Cite

Background Being able to predict preterm birth is important, as it may allow a high-risk population to be selected for future interventional studies and help in understanding the pathways that lead to preterm birth.Objective To investigate the accuracy of novel biomarkers to predict spontaneous preterm birth in women with singleton pregnancies and no symptoms of preterm labour.Search strategy Electronic searches in PubMed, Embase, Cinahl, Lilacs, and Medion, references of retrieved articles, and conference proceedings. No language restrictions were applied.Selection criteria Observational studies that evaluated the accuracy of biomarkers proposed in the last decade to predict spontaneous preterm birth in asymptomatic women. We excluded studies in which biomarkers were evaluated in women with preterm labour.Data collection and analysis Two reviewers independently extracted data on study characteristics, quality, and accuracy. Data were arranged in 2 · 2 contingency tables and synthesised separately for spontaneous preterm birth before 32, 34, and 37 weeks of gestation. We used bivariate meta-analysis to estimate pooled sensitivities and specificities, and calculated likelihood ratios (LRs).Main results A total of 72 studies, including 89 786 women and evaluating 30 novel biomarkers, met the inclusion criteria. Only three biomarkers (proteome profile and prolactin in cervicovaginal fluid, and matrix metalloproteinase-8 in amniotic fluid) had positive LRs > 10. However, each of these biomarkers was evaluated in only one small study. Four biomarkers had a moderate predictive accuracy (interleukin-6 and angiogenin, in amniotic fluid; human chorionic gonadotrophin and phosphorylated insulin-like growth factor binding protein-1, in cervicovaginal fluid). The remaining biomarkers had low predictive accuracies.Conclusions None of the biomarkers evaluated in this review meet the criteria to be considered a clinically useful test to predict spontaneous preterm birth. Further large, prospective cohort studies are needed to evaluate promising biomarkers such as a proteome profile in cervicovaginal fluid.

show abstract

“…5,6 Elevated serum ferritin also has been used as a harbinger of tissue masses including ovarian carcinoma, 7 Hodgkin disease, 8 renal cell carcinoma, 9 and melanoma, 10 and preterm deliveries. 11,12 Ferritin has been linked to insulin resistance [13][14][15] and, controversially, to atherosclerosis. 16 Thus, serum ferritin has been used for the diagnosis and follow-up of numerous disorders, although it is most strongly linked to intracellular iron status and adult Still disease.…”

Section: Introductionmentioning

confidence: 99%

Regulated secretion of glycosylated human ferritin from hepatocytes

Ghosh

Hevi

Chuck

2004

Blood

118

View full text Add to dashboard Cite

Serum ferritin has been used widely in clinical medicine chiefly as an indicator of iron stores and inflammation. Circulating ferritin also can have paracrine effects. Despite the clinical significance of serum ferritin, its secretion remains an enigma. The consensus view is that serum ferritin arises from tissue ferritinsprincipally ferritin light-which can be glycosylated. Ferritin heavy and light chains are cytosolic proteins that form cages of 24 subunits to store intracellular iron. We show that ferritin light is secreted when its expression is increased in stable, transfected HepG2 cells or adenovirus-infected HepG2 cells. Export occurs through the classical secretory pathway and some chains are N-glycosylated. Ferritins do not need to form cages prior to secretion. Secretion is blocked specifically, effectively, and rapidly by a factor in serum. The timing of this inhibition of ferritin secretion suggests that normally cytosolic ferritin L is targeted to the secretory pathway during translation despite the absence of a conventional signal sequence. Thus, secretion of glycosylated and unglycosylated ferritin is a regulated and not a stochastic process. IntroductionSerum ferritin has wide clinical utility primarily as an indicator of intracellular iron stores 1-3 and as an acute-phase reactant useful for the diagnosis and follow-up of adult Still disease 4 and systemic lupus erythematosis. 5,6 Elevated serum ferritin also has been used as a harbinger of tissue masses including ovarian carcinoma, 7 Hodgkin disease, 8 renal cell carcinoma, 9 and melanoma, 10 and preterm deliveries. 11,12 Ferritin has been linked to insulin resistance [13][14][15] and, controversially, to atherosclerosis. 16 Thus, serum ferritin has been used for the diagnosis and follow-up of numerous disorders, although it is most strongly linked to intracellular iron status and adult Still disease.Despite the frequent use in clinical medicine of measurements of serum ferritin, most aspects of its secretion remain unknown. An understanding of the mechanism and regulation of the secretion of ferritin would inform the use of this commonly used clinical test. Moreover, the trafficking of normally cytosolic ferritins is relevant to the physiology of iron homeostasis and the pathophysiology of many disorders in which intracellular ferritin could play a role. [17][18][19][20] There are 2 forms of ferritin that function together to store iron in cells. 2 In humans, ferritin light (L) has a molecular mass of 19 kDa and consists of 175 amino acids. Human ferritin L is 53% identical to ferritin heavy (H), which contains 183 amino acids and is 21 kDa. 21 Unlike ferritin L, ferritin H contains a ferroxidase site. Cages that store iron atoms are formed from 24 ferritin monomers in varying ratios of H/L. [21][22][23] Both ferritin H and L subunits are necessary for efficient iron storage; although ferritin L lacks a ferroxidase site, the protein nucleates iron mineralization. 21,24 Ferritin is secreted from liver 25,26 and lymphoid cells. 27 Some studies...

show abstract

Serum Ferritin: A Predictor of Early Spontaneous Preterm Delivery

Abstract: Elevated serum ferritin levels during the second trimester are predictive of early spontaneous preterm delivery, possibly because these reflect an acute-phase reaction to subclinical infections that are closely associated with premature delivery.

Cited by 100 publications

References 24 publications

Anemia and iron deficiency: effects on pregnancy outcome

Anemia and iron deficiency: effects on pregnancy outcome

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Regulated secretion of glycosylated human ferritin from hepatocytes

Contact Info

Product

Resources

About