Serum ferritin as a clinical marker for renal cell carcinoma: influence of tumor volume

Partin, Alan W.; Criley, Stuart Ross; Steiner, Mitchell S.; Hsieh, Kisseng; Simons, Jonathan W.; Lumadue, Jeanne A.; Carter, H.Ballentine; Marshall, Fray F.

doi:10.1016/0090-4295(95)80007-7

Cited by 41 publications

(35 citation statements)

References 23 publications

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“…The mean cytosolic ferritin level of cancer tissue was also much higher than that from normal parenchyma [35,36]. However, the actual reasons for the ferritin increases in the RCC tissue remain unclear [36]. In our study, blood samples were collected on average 6.6 years before clinical diagnosis of RCC, suggesting that low serum ferritin in the RCC cases may be due to the translocation of ferritin from the circulatory system (blood) to the pre-cancerous tissue (kidney).…”

Section: Discussionmentioning

confidence: 98%

“…It was shown that the mean serum ferritin level from the renal vein correlated with tumor stage and was significantly higher than that from the peripheral vein [34]. The mean cytosolic ferritin level of cancer tissue was also much higher than that from normal parenchyma [35,36]. However, the actual reasons for the ferritin increases in the RCC tissue remain unclear [36].…”

Section: Discussionmentioning

confidence: 99%

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Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

Ali

Akhmedkhanov

Zeleniuch-Jaquotte

et al. 2003

Cancer Detection and Prevention

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Reliability of serum levels of iron, ferritin and nitrite (NO 2 − ) over a 2-year period were evaluated in 40 healthy women (20 pre-menopausal and 20 post-menopausal), ages 39-65 years, from the New York University Women's Health Study (NYUWHS). Three blood samples per woman collected at yearly intervals were analyzed. Reliability coefficients (RCs) of serum iron, ferritin, and nitrite were 0.03 (95% confidence interval ( In a case-control study nested within NYUWHS cohort, serum levels of nitrite, ferritin, and iron were measured in women apparently healthy at the time of blood donation but diagnosed with renal cancer 1.8-12.2 years later (n = 24) and in individually matched controls (two per case). The results suggest that high serum levels of ferritin and nitrite may be associated with a decreased risk of renal cancer (odds ratio (OR), 0.55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

Ali

Akhmedkhanov

Zeleniuch-Jaquotte

et al. 2003

Cancer Detection and Prevention

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“…Elevation of serum ferritin levels in cancer patients may be related to a multifactorial mechanism, as abnormal production and release of ferritin from tumor cells is postulated to explain increased ferritin levels (8,9). A correlation between size of the primary tumor and serum ferritin has been demonstrated in renal cell carcinoma (9).…”

Section: Discussionmentioning

confidence: 99%

“…Very elevated serum levels of ferritin are generally indicative of iron overload (30), but high serum ferritin concentrations may be observed in various chronic dis- Wide faint line (n=51), normal ferritin levels (women 11-148 ng/mL; men 30-215 ng/mL); dotted line (n=14), low ferritin levels (women <11 ng/mL; men <30 ng/mL); single thick line (n=29), high ferritin levels (women >148 ng/mL; men >215 ng/mL eases and neoplasms (2,(6)(7)(8)(9)(10)(11). Elevation of serum ferritin levels in cancer patients may be related to a multifactorial mechanism, as abnormal production and release of ferritin from tumor cells is postulated to explain increased ferritin levels (8,9).…”

Section: Discussionmentioning

confidence: 99%

“…In patients with colorectal disease, low ferritin levels may be a sign of iron deficiency anemia; this parameter may be of value in planning a preoperative supplement in order to reduce the postoperative complications of colorectal surgery (3,4). As a tumor marker, ferritin has been evaluated in patients with various types of cancer and has been demonstrated to be a useful marker in some malignancies (5)(6)(7)(8)(9)(10)(11). In colorectal cancer patients, preoperative serum ferritin level has been evaluated in a limited number of studies without survival analysis (3,(10)(11)(12)(13)(14)(15) and therefore its prognostic significance has not been well defined.…”

Section: Introductionmentioning

confidence: 99%

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Serum Ferritin in Colorectal Cancer Patients and its Prognostic Evaluation

Lorenzi

Vernillo

2006

Int J Biol Markers

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The aim of this study was to investigate the relationship between preoperative serum ferritin levels, clinicopathological parameters and survival analysis of patients with colorectal cancer. Ninety-four patients (57 males) with a mean age of 65 years (39-87 years) underwent 63 curative and 31 palliative operations. Follow-up was at least 5 years. Patients were categorized with normal (30-215 ng/mL in men and 11-148 ng/mL in women), low, or high serum ferritin levels. Prognostic evaluation was undertaken with stratified survival analysis and Cox's regression model. Twenty-nine of the patients (30.9%) had raised ferritin levels and 14 (14.9%) had low values. Comparisons of the survival curves showed significant differences in stage C disease; specifically, patients with either low or high ferritin levels had a shorter survival than patients with normal levels. Patients who underwent palliative surgery and had high ferritin serum values also had a shorter survival. In multivariate analysis, the variables with a negative effect on survival were stage, serum ferritin levels and age. Our data suggest that patients with advanced colorectal cancer having normal preoperative serum ferritin levels may have a better prognosis, although the prognostic value related to this association requires further investigation.

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The detection of renal carcinoma cells in the peripheral blood with an enhanced reverse transcriptase-polymerase chain reaction assay for MN/CA9

McKiernan

Buttyan

Bander

et al. 1999

Cancer

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BACKGROUND Using a reverse transcriptase–polymerase chain reaction (RT‐PCR) assay, the authors previously determined the expression of MN/CA9 mRNA in renal cell carcinoma (RCC) and its absence in benign renal tissue. In the current study, the utility of an enhanced RT‐PCR assay in the detection of renal carcinoma cells in the peripheral blood was assessed. METHODS An enhanced MN/CA9 RT‐PCR assay was applied to peripheral blood samples from a total of 96 patients. Forty‐two patients had renal tumors, including 5 with benign renal lesions, 28 with localized RCC, and 9 with metastatic RCC. Fifty‐four control patients without renal tumors were similarly tested. Pathologic staging for patients with localized cancer was T1N0M0 for 5, T2N0M0 for 9, and T3N0M0 for 14 patients. RESULTS Cells expressing MN/CA9 were detected in 1 of 54 controls (1.8%) and in 18 of 37 cancer patients (49%). Thirteen of twenty eight patients (46%) with localized RCC and 5 of 9 (56%) with metastatic disease tested positive with the assay. No patient with a benign renal tumor exhibited MN/CA9 expression. All blood test results for patients with clear cell RCC were noted to be positive. No correlation was noted between MN/CA9 results and age, gender, or tumor grade. The differences in MN/CA9 results according to T classification were not statistically significant. CONCLUSIONS The enhanced RT‐PCR assay for MN/CA9 is a highly specific technique for detecting circulating renal carcinoma cells in the peripheral blood, and it may prove useful in the diagnosis and monitoring of RCC. Cancer 1999;86:492–7. © 1999 American Cancer Society.

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Serum ferritin as a clinical marker for renal cell carcinoma: influence of tumor volume

Cited by 41 publications

References 23 publications

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women

Serum Ferritin in Colorectal Cancer Patients and its Prognostic Evaluation

The detection of renal carcinoma cells in the peripheral blood with an enhanced reverse transcriptase-polymerase chain reaction assay for MN/CA9

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