Serum ferritin as a third marker in germ cell tumours

Grail, Ann; Bates, Gillian; Ward, A. Milford; Jones, W G; Hancock, B. W.

doi:10.1016/0277-5379(82)90045-1

Cited by 12 publications

(4 citation statements)

References 12 publications

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“…Such patterns of serum ferritin levels were observed when RPLND, irradiation or chemotherapy regimens with out cis-diammincdichloroplatinum were the modes of treatment. These findings are in accord with those of Grail et al [7,8], who found that serum ferritin may be an index of response to therapy or recurrence of tumor.…”

Section: Discussionsupporting

confidence: 80%

“…However, the finding of elevated serum ferritin concentration not associated with tumor -in a 3rd of the patients with disease-free status, i.e., in stage I patients after orchiectomy argues against the potential use of this marker as a staging factor. These findings are in accord with Engelmann et al [9], although at variance with other workers [7,8].…”

Section: Discussioncontrasting

confidence: 44%

“…Because the highest amount of body ferritin is in the liver, spleen and kidneys, it could be anticipated that platinum, known for its high nephrotoxicity [16], high uptake in the liver [17], and some hepatotoxicity [18], might lead to hyperferritinemia. Discordant be havior of the conventional markers and ferritin during chemotherapy has been reported by Grail et al [8], although it was not attributed to platinum. The above data, together with results reported here, might sug gest that hyperferritinemia is a very sensitive index of platinum toxicity.…”

Section: Discussionmentioning

confidence: 86%

“…Another marker, ferritin, has been initially demon strated by indirect immunofluorescence in cells of embryonal carcinoma and immature teratoma [4] and later by indirect immunoperoxidase staining in cells of seminoma and some nonseminomatous tumors: cmbryonal carcinoma, yolk sac tumor, and teratoma [5,6], This marker has not been found in choriocar cinoma and syncytiotrophoblastic giant cells [6], Elevated concentrations of ferritin in serum have been observed in patients with embryonal carcinoma, teratoma and yolk sac tumor [4,7,8], and regarded as an adjunct marker to hCG and AFP [7,8]. On the contrary, other workers have claimed [9] that ferritin concentrations in serum cannot discriminate among histological tumor types or tumor stages, and are influenced by hepatic factors and anemia more than by the tumor itself.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Usefulness of Serum Ferritin Measurements in Patients with Testicular Germ Cell Tumors

Szymendera¹,

Kozłowicz-Gudzińska²,

Madej³

et al. 1985

Oncology

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In 50 patients with seminoma and in 50 with nonseminomatous germ cell tumors of the testis, serum levels of conventional markers (CEA, AFP, hCG) and ferritin were measured at the time of admission and during management. The conventional markers behaved as reported previously. After orchiectomy, elevated levels of ferritin were found in the presence as well as in the absence of tumor; the extent of these elevations was highly variable. Serial determinations of serum ferritin showed two patterns of variation. First, in patients treated with retroperitoneal lymph node dissection, irradiation, and chemotherapy regimens without platinum, decreasing levels of the conventional markers and serum ferritin were associated with response to therapy and increasing levels with relapse of tumor. Second, in patients treated with chemotherapy regimens containing cis-diamminedichloroplatinum, the conventional markers returned to normal values while the ferritin level doubled or tripled and returned to pretreatment or normal values only several weeks after therapy. Thus, it appears that hyperferritinemia was a sensitive index of platinum toxicity. We conclude that the serum ferritin level has no value in staging after orchiectomy but is a useful index of response to therapy during treatment with retroperitoneal lymph node dissection, irradiation or chemotherapy without platinum or relapse of tumor. During treatment with platinum, elevated levels might be explained as a possible toxic side effect of this drug.

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Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Usefulness of Serum Ferritin Measurements in Patients with Testicular Germ Cell Tumors

Szymendera¹,

Kozłowicz-Gudzińska²,

Madej³

et al. 1985

Oncology

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An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis

Ya-You

Liu

Boyun

et al. 1989

Cancer

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The distribution of ferritin in 36 autopsy cases of malignant histiocytosis was investigated by immunocytochemical staining, together with the detection of alpha 1-antichymotrypsin, alpha 1-antitrypsin, lysozyme, S-100 protein, and ricinus communis agglutinin in the consecutive sections. The results showed that ferritin-positive tumor cells were present in every case. The quantity of cellular ferritin in well-differentiated histiocytes was higher than that in atypical histiocytes. Double labeling showed that ferritin and alpha 1-antichymotrypsin might be located either in one tumor cell or in separate cells. Our data suggest that ferritin may be a tumor associated antigen in malignant histiocytosis, playing a regulatory role for tumor cell differentiation.

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Tumour Markers

Bagshawe¹

1985

Ovarian Cancer

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Serum ferritin as a third marker in germ cell tumours

Cited by 12 publications

References 12 publications

Clinical Usefulness of Serum Ferritin Measurements in Patients with Testicular Germ Cell Tumors

Clinical Usefulness of Serum Ferritin Measurements in Patients with Testicular Germ Cell Tumors

An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis

Tumour Markers

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