Serum fetuin-A levels in patients with systolic heart failure

Abstract

Serum fetuin-A is decreased in CHF patients, indicating that anti-inflammatory activity is downregulated in CHF and that calcification may be associated with CHF.

Fetuin-A and sodium concentrations are independently associated with all-cause mortality in patients awaiting heart transplantation

“…Furthermore, the authors observed lower fetuin -A concentrations among NYHA class III and IV patients than among those in lower functional capacity classes (NYHA I and II). 9 In accordance with our results, Keçebaş et al 9 reported that a worse prognosis was associated with lower serum fetuin concentrations. This finding could suggest that the anti--inflammatory activity of fetuin -A is downregulated in end -stage HF.…”

“…In recent years, several studies have focused on the role of fetuin -A in the pathophysiology of cardiovascular diseases. [9][10][11][12] Fetuin -A (α 2 -Heremans -Schmid glycoprotein) is a multifunctional glycoprotein which is viewed as an important component of various normal and pathological processes, including macrophage deactivation, insulin resistance, protease activity control, recovery from acute inflammation, and bone metabolism regulation. 9,10 Considering the properties of fetuin -A and its potential role in the pathophysiology of cardiovascular diseases, it may also become a useful marker for evaluating patients with end -stage HF.…”

Proteomic diversity of high‐density lipoprotein explains its association with clinical outcome in patients with heart failure

“…These 12 proteins notably reflected, among others, processes related to atherogenesis, inflammation, and oxidative stress. Not much is known about their association with HF (outcome), but alpha‐2‐HS‐glycoprotein (also called fetuin‐A) levels were found to be lower in chronic HF patients, lower levels of APOA1 have been associated with worse prognosis in HF, higher beta‐2‐microglobulin levels have been proposed as a cardiovascular risk marker in HF, and decreased PON1 activity and levels have been associated with HF and adverse outcomes in HF . We will elaborate on FLNA, SFTPB, and APOC3 in the next section.…”

Can Fetuin A Be Utilized in the Evaluation of Elderly Patients with Acute Myocardial Infarction?

“…During this process, pro-inflammatory cytokines inhibit the synthesis of FA in the liver. Consequently, low FA levels will facilitate the ongoing inflammation and production of cardio-toxic cytokines, such as TNF alpha [ 22 ], leading to harmful consequences (LV dilatation, HF, mechanical complications) [ 23 , 24 , 25 , 26 ].…”