Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study

Fındıklı, Hüseyin Avni; Erdoğan, Murat

doi:10.23736/s0375-9393.20.14855-7

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…they showed that a value >2.58 pg/ml was an independent prognostic factor to predict 28-day mortality with 85.7% sensitivity and 72.1% specificity. 74 Inflammation, organ dysfunction, and platelet activation affect platelet morphology in critically-ill patients. [75][76][77] Fogagnolo et al investigated the prognostic values of platelets distribution width (PDW) and mean platelet value (MPV) in critically ill patients.…”

confidence: 99%

A year in review in Minerva Anestesiologica 2019. Critical care

et al. 2020

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confidence: 99%

A year in review in Minerva Anestesiologica 2019. Critical care

et al. 2020

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“…Fifty-three studies (88.3%) were cohorts, three analysing data from a randomised controlled trial. One study team reported information about a similar set of patients from the same institution in two different publications [ 32 , 63 ]; we included the data form the report with the largest sample size (187 patients versus 160). Study funding was mainly public (22 studies, 36.7%), with 20 studies not reporting this information.…”

Section: Resultsmentioning

confidence: 99%

Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis

Molano-Franco,

Arevalo-Rodriguez,

Muriel

et al. 2023

Diagn Progn Res

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Background Numerous biomarkers have been proposed for diagnosis, therapeutic, and prognosis in sepsis. Previous evaluations of the value of biomarkers for predicting mortality due to this life-threatening condition fail to address the complexity of this condition and the risk of bias associated with prognostic studies. We evaluate the predictive performance of four of these biomarkers in the prognosis of mortality through a methodologically sound evaluation. Methods We conducted a systematic review a systematic review and meta-analysis to determine, in critically ill adults with sepsis, whether procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), and presepsin (sCD14) are independent prognostic factors for mortality. We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials up to March 2023. Only Phase-2 confirmatory prognostic factor studies among critically ill septic adults were included. Random effects meta-analyses pooled the prognostic association estimates. Results We included 60 studies (15,681 patients) with 99 biomarker assessments. Quality of the statistical analysis and reporting domains using the QUIPS tool showed high risk of bias in > 60% assessments. The biomarker measurement as a continuous variable in models adjusted by key covariates (age and severity score) for predicting mortality at 28–30 days showed a null or near to null association for basal PCT (pooled OR = 0.99, 95% CI = 0.99–1.003), CRP (OR = 1.01, 95% CI = 0.87 to 1.17), and IL-6 (OR = 1.02, 95% CI = 1.01–1.03) and sCD14 (pooled HR = 1.003, 95% CI = 1.000 to 1.006). Additional meta-analyses accounting for other prognostic covariates had similarly null findings. Conclusion Baseline, isolated measurement of PCT, CRP, IL-6, and sCD14 has not been shown to help predict mortality in critically ill patients with sepsis. The role of these biomarkers should be evaluated in new studies where the patient selection would be standardized and the measurement of biomarker results. Trial registration PROSPERO (CRD42019128790).

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“…RANKL levels in mesenchymal stem cells (MSCs), T cells, and B cells are also up-regulated, leading to osteoporosis [ 41 ]. In addition, estradiol levels in septic patients are positively correlated with disease severity and mortality, regardless of gender, and the authors believe that estradiol levels can be used as prognostic markers [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

“…Animal experiments and clinical studies have shown that estrogen closely linked to immune response: increases the phagocytic function of macrophages, and shows an immunomodulatory effect with the increase of cytokines and chemokines [47][48][49]. Estrogen deficiency leads to the increase of IL-7 to promote the activation of T cells, and T cells secrete immunologically active substances, such as IL-1, IL-6 and TNF-α, which promote the formation of osteoclasts [42].…”

Section: The Estrogen-endocrine Pathwaymentioning

confidence: 99%

Critical illness and bone metabolism: where are we now and what is next?

2022

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Critical illness refers to the clinical signs of severe, variable and life-threatening critical conditions, often accompanied by insufficiency or failure of one or more organs. Bone health of critically ill patients is severely affected during and after ICU admission. Therefore, clinical work should focus on ICU-related bone loss, and early development and implementation of related prevention and treatment strategies: optimized and personalized nutritional support (high-quality protein, trace elements and intestinal prebiotics) and appropriate physiotherapy and muscle training should be implemented as early as possible after ICU admission and discharge. At the same time, the drug regulates excessive metabolism and resists osteoporosis.

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Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study

Cited by 8 publications

References 23 publications

A year in review in Minerva Anestesiologica 2019. Critical care

A year in review in Minerva Anestesiologica 2019. Critical care

Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis

Critical illness and bone metabolism: where are we now and what is next?

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