Serum gamma glutamyl transferase levels in association with lipids and lipoproteins in type2 diabetes mellitus

Abstract

Background: Serum gamma glutamyl transferase is widely used as a marker for alcohol induced liver disease. Recently it has gained importance due to its role in type2 diabetes mellitus. A raised serum gamma glutamyl transferase level indicates hepatic steatosis and visceral fat deposition, leading to insulin resistance and diabetes. In the present study we examined the association between serum gamma glutamyl transferase levels with lipids and lipoproteins in diabetes mellitus. Methods:The study was carried out on 50 subjects with type 2 diabetes mellitus and compared with 50 age and sex matched healthy controls attending outpatient department of general medicine, Narayana medical college, Nellore. Serum gamma glutamyl transferase was measured by calorimetric kinetic assay. Fasting blood sugar was measured by glucose oxidase method using automated analyzer. Serum triglycerides, total cholesterol and high density lipoprotein are measured by standard enzymatic procedures and low density lipoprotein by Friedwald equation. Results: Serum gamma glutamyl transferase levels in diabetic cases were significantly elevated compared to normal healthy controls (P <0.001). There was a positive correlation between gamma glutamyl transferase, lipids and low density lipoprotein and inverse correlation with high density lipoprotein (r = -0.298). Conclusion: Our results suggest a possible role of gamma glutamyl transferase in the pathophysiology and progression of type 2 diabetes mellitus.

Effect of methanolic extract of Ventilago maderaspatana leaves on liver function markers and histopathology of liver tissue in streptozotocin-induced diabetic rats

“…Gamma-Glutamyl Transferase (GGT) was found in a variety of tissues, but the liver stood out above the others. However, it was related with ALP as a marker of cholestasis and was a highly sensitive but unreliable indicator of liver illness (38). Recent studies have employed serum gamma glutamyl transferase as a measure for oxidative stress.…”

Gamma glutamyl transferase in Type II diabetes mellitus patients attending tertiary care academic hospital

“…2 Serum GGT was also correlated with insulin resistancemarkers, waist-circumference, triglycerides, fasting plasma glucose, HbA1c, systolic, and diastolic blood pressure. 8 Although the biological mechanisms are not completely understood, mounting evidence suggests that GGT and UA may be involved in the development of diabetes. Concerning GGT levels, serum GGT may predict diabetes incidence as a marker for oxidative stress related to GSH levels, with GSH performing critical antioxidant defense for the cell.…”