Serum Glycated Albumin as a Glycemic Control Marker in Diabetic Cats

Abstract

Abstract. Measurements of glycated proteins such as serum fructosamine, glycated hemoglobin, and glycated albumin (GA) are increasingly used to complement serum glucose concentration for better management of diabetes mellitus. For example, the degree of glycemic control in diabetic cats can be determined by evaluating fructosamine concentration. Unfortunately, fructosamine tests are currently not performed in Japan, and as such, the measurement of GA may serve as a replacement test. The objectives of the current study were 2-fold. First, serum GA and fructosamine level were evaluated for positive correlation in cats as a preliminary gauge on whether serum GA use is applicable. Second, a GA percentage reference range was determined from healthy control cats for possible future diagnostic use. A positive correlation was determined for fructosamine and GA in both normal and diabetic cats. Moreover, the serum GA percentage reference interval based on control cats was determined to be 7.5-13.9% (95% nonparametric interfractile interval). Interestingly, no significant difference in serum GA percentages was observed between samples from diabetic cats with excellent glycemic control and control cats. However, good, fair, and poor glycemic control diabetic cats resulted in a significant increase in serum GA percentages in comparison to control cats. Therefore, these results indicate that serum GA may be a useful glycemic control indicator that could substitute for fructosamine to monitor glycemic control in diabetic cats.

The effect of Insulin Degludec on glycemic control in diabetic cats over a 12-month period

“…Due to the vast biological variability between animals, the sample number used in this study was too small to accurately assess 8 glycemic control (e.g., GA). Despite this, GA can provide an index of glycemic control for the previous 1-3 weeks and can be used as a substitute for the evaluation of fructosamine concentration in cats [8]. Therefore, the effect of IDeg using GA as a glycemic control marker was calculated.…”

“…A serum GA of over 20 % was considered abnormal and a normal reference range of GA was 7.5-13.9 % for GA (%) (95 % C.I.) in normal healthy cats [8]. Five of the eight cats were newly diagnosed as diabetic and had not had insulin administered prior to this investigation.…”

“…The initial dosages administered to the previously untreated diabetic cats were 0.5 -2.0 units/cat/once or twice a day depending upon clinical signs and GA levels. These doses were adjusted throughout the treatment period according to the clinical condition of each individual (such as improvement in polyuria/polydipsia and increasing body weight) and the serum GA level for maintaining 11.9-25.6 % (between excellent to fair glycemic control) [8].…”

Avaliação dos níveis de frutosamina em gatos sob estresse agudo e crônico

“…Portanto, a mensuração da frutosamina é considerada o teste padrão ouro para a avaliação da glicemia em gatos diabéticos 8 . A frutosamina é um parâmetro válido para o diagnóstico e controle metabólico do DM em cães e gatos, avaliando-se a adequação da insulinoterapia 9 .…”

Long-term management and postmortem examination in a diabetic cat with acromegaly treated with two courses of radiation therapy

“…Serum biochemistry results showed elevated fasting hyperglycemia (412 mg/d l ) and hypertriglyceridemia (1,098 mg/d l ). Serum glycated albumin (GA) was 21.7%, indicating an early diagnosis of diabetes mellitus [12]. Urinalysis revealed high glucose concentration, ketonuria, and high specific gravity (>1.050).…”