Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy—a critical assessment

Brändle, E; Hautmann, Oliver; Bachem, Max G.; Kleinschmidt, K.; Gottfried, H. W.; Grünert, A.; Hautmann, Richard E.

doi:10.1016/s0090-4295(98)00593-7

Cited by 29 publications

(16 citation statements)

References 18 publications

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“…In particular, we tried to verify whether, as occurs for PSA levels, RRP produces a rapid increase and then a significant reduction in serum CgA levels. In our experience, perioperative and postoperative variability in serum PSA was similar to that reported in previous studies [4,6,15,19,20,22]. Different postoperative variations in serum CgA levels were found.…”

Section: Discussionsupporting

confidence: 90%

Variation of Chromogranin a Serumlevels After Radical Retropubic Prostatectomy for Prostate Adenocarcinoma

Sciarra

Gentile

Monti

et al. 2003

Archives of Andrology

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This study evaluated perioperative and postoperative variations in serum CgA levels induced by radical retropubic prostatectomy (RRP) and their relationship with serum PSA levels in prostate cancer patients. Thirty consecutive patients with clinically localized adenocarcinoma of the prostate undergoing RRP were prospectively analyzed. Serum levels of CgA and total PSA were analyzed in each case preoperatively (time 0), at removal of the prostate (time 1), 1 h after the end of RRP (time 2) and then at regular postoperative intervals till 12 weeks (time 14). During the postoperative period no adjuvant therapies were performed and none of the 30 cases showed biochemical (PSA > 0.2 ng=mL) and=or clinical progression. Mean preoperative serum levels of CgA were 57 AE 14 ng=mL. Immediately after the surgical removal of the prostate gland (time 1), in all 30 cases there was a significant (time 0-time 1: p ¼ .001) increase in serum PSA, but a nonsignificant modification in serum CgA levels (60 AE 15 ng=mL). After time 1, serum PSA levels progressively decreased to below the detection limit of 0.2 ng=mL. On the contrary, at time 2, serum CgA levels were postoperatively increased (time 2 ¼ 145 AE 47) and they remained significantly higher than preoperative values (time 0) till the 21-day postoperative interval (time 11). Moreover, at the last control (time 14) mean and median CgA levels were very similar to those shown preoperatively (time 14: 58 AE 18 ng=mL). In patients with untreated clinically localized adenocarcinoma of the prostate submitted to RRP, surgical and postoperative stress, more than surgical manipulation of the prostate gland, could produce a significant increase in serum CgA levels maintained for a longer period when compared to the increase in serum PSA levels.

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Section: Discussionsupporting

confidence: 90%

Variation of Chromogranin a Serumlevels After Radical Retropubic Prostatectomy for Prostate Adenocarcinoma

Sciarra

Gentile

Monti

et al. 2003

Archives of Andrology

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“…There is universal agreement that fPSA follows a two-compartment model of elimination, with the a-phase ranging from 0.57 to 1.8 h, and the b-phase half-life lasting 6.0-22 h. 16,18,19,24,25,28 Our results agree with this two-phase cPSA and fPSA elimination BJ Martin et al pattern of elimination, but our calculated half-lives appear to be much shorter than those previously published, with an initial half-life of 0.50 h and a later half-life of 4.20 h. Again, this suggests African-American men eliminate fPSA faster than Caucasian men. There are currently three theories to explain the two-compartment model of fPSA elimination.…”

Section: Discussionmentioning

confidence: 84%

“…Presumably, these studies were performed primarily on Caucasian patients, and there is disagreement on the best model for elimination. For those supporting a first-order elimination, half-lives range from 45.6 to 75.6 h. 20,26,27 For those espousing a two-compartment model, the b-phase half-lives range from 33 to 182 h. 1,16,24,26,28 It is possible that the twocompartment models with tPSA truly reflect an a-phase elimination of fPSA and the b-phase represents the firstorder elimination of cPSA.…”

Section: Discussionmentioning

confidence: 99%

“…The final theory states that the initial phase merely reflects perioperative hemodynamic changes and fluid shifts, so that the true elimination of fPSA does not manifest until the prolonged, later bphase. 1,16,25 Brandle et al, 16 found that serum protein and albumin concentrations demonstrated statistically similar rates of decay to fPSA and tPSA in the immediate postoperative period, suggesting that the a-phase was an artifact.…”

Section: Discussionmentioning

confidence: 99%

“…16 If one assumes a constant intravascular volume, a drop in the serum protein concentration postoperatively could reflect dilutional effects, and the true concentration of other blood-borne substances would be in effect higher. While the actual blood volume undoubtedly does fluctuate, this simple assumption allows us to construct a model relating relative hemodilution to the PSA concentration.…”

Section: Methodsmentioning

confidence: 99%

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cPSA and fPSA elimination in African-American men

Martin

Cheli

Davis

et al. 2003

Prostate Cancer Prostatic Dis

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In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an a-phase elimination of 0.50 h and a b-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.

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Total and free PSA kinetics in patients without prostate cancer undergoing radical cystoprostatectomy

et al. 2008

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Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy—a critical assessment

Cited by 29 publications

References 18 publications

Variation of Chromogranin a Serumlevels After Radical Retropubic Prostatectomy for Prostate Adenocarcinoma

Variation of Chromogranin a Serumlevels After Radical Retropubic Prostatectomy for Prostate Adenocarcinoma

cPSA and fPSA elimination in African-American men

Total and free PSA kinetics in patients without prostate cancer undergoing radical cystoprostatectomy

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