Serum haptoglobin levels in patients with melancholic and nonmelancholic major depression

Erdem, Murat; Çeli̇k, Cemi̇l; Çaycı, Tuncer; Özdemir, Barbaros; Kurt, Yasemin Gülcan; Akgül, Emin Özgür; Yaman, Halıl; Balıkçı, Adem; Uzun, Özcan

doi:10.1016/j.pnpbp.2011.01.009

Cited by 13 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding needs further confirmation, but may be of interest in view of studies demonstrating antinociceptive effects of IL-10 ( 48 ) and amplified exhaustion and motor deficits in IL-10-deficient mice after bacterial challenge ( 49 ). In contrast to previous work, we did not find evidence for specific associations of inflammatory markers with somatic depressive symptoms ( 9 – 11 ) or depression subtypes ( 14 – 19 ). The reasons for these inconsistencies are unclear, but may relate to differences in study populations and assessment instruments.…”

Section: Discussioncontrasting

confidence: 99%

“…For example, some studies ( 9 – 11 ), but not all ( 12 ), suggest that inflammation may be particularly associated with somatic depressive symptoms. Other studies indicate that a later age of onset ( 13 ) may relate to higher levels of inflammatory markers, while findings for specific depression subtypes are mixed ( 14 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

et al. 2017

View full text Add to dashboard Cite

Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Outcome of Psychological Interventions in Depression trial, this exploratory study examines associations between depression subtypes and pathogenetic characteristics (i.e., melancholic vs non-melancholic depression, chronic vs non-chronic depression, age of onset, cognitive-affective and somatic symptom dimensions) with plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and numbers of leukocyte subpopulations in 98 patients with major depression (MD) and 30 age and sex-matched controls. Patients with MD exhibited higher CRP levels, higher neutrophil and monocyte counts, lower IL-10 levels, and an increased neutrophil to lymphocyte ratio (NLR) than controls. Patient with later age of onset had higher levels of two inflammatory markers (CRP, NLR) and lower cytotoxic T cell counts after adjusting for sociodemographics, lifestyle factors, and antidepressants. Furthermore, lower anti-inflammatory IL-10 levels were related to more severe somatic depressive symptoms. These results confirm and extend previous findings suggesting that increased levels of CRP are associated with a later onset of depression and demonstrate that also NLR as a subclinical inflammatory marker is related to a later onset of depression.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

et al. 2017

View full text Add to dashboard Cite

show abstract

“…They also mentioned that there was a positive correlation between depression severity and serum Hp concentrations among the major depressed patients [51]. Therefore, the type and severity of depression affect the serum concentration of acute-phase response proteins.…”

Section: Discussionmentioning

confidence: 99%

Lack of association of acute phase response proteins with hormone levels and antidepressant medication in perimenopausal depression

et al. 2014

View full text Add to dashboard Cite

BackgroundMajor depression is associated with higher plasma levels of positive acute-phase proteins, as well as with lower plasma levels of negative acute-phase proteins. The aim of this study is to examine the levels of acute-phase response proteins and whether these levels are influenced by reproductive hormones and antidepressant medication in the perimenopausal depression.MethodsSixty-five women (age range: 40–58 years old) participated in this study. All women were in the perimenopausal phase. The diagnosis of depression was made through a psychiatric interview and with the aid of Hamilton Depression Rating Scale 17 (HAM-D 17). The acute-phase response proteins, such as haptoglobin (HP), transferrine (TRf), α1-antitrypsin, complement protein 3 (C3), complement protein 4 (C4) and C-reactive protein (CRP) and the reproductive hormones, for example follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2), were analyzed using standard laboratory methods. Pearson’s correlations were applied to evaluate the relationship between acute-phase proteins and hormones.ResultsPerimenopausal women were divided into three groups. The first group consisted of normal controls, the second one involved depressed perimenopausal women, who were taking selective serotonin reuptake inhibitors (SSRIs), and the third one included depressed women that were not treated with SSRIs. Depressed women in perimenopause, when being compared to non-depressed women, did not differ as to serum levels of acute-phase proteins. There was a positive correlation between HP and E2 in depressed perimenopausal women, who were not taking SSRIs.ConclusionsThe lack of association between acute-phase proteins and depressive mood mentioned in this study does not support previous findings in patients with major depression. This negative finding in perimenopausal depression indicates either the absence or a more complex nature of the interactions between acute-phase proteins, low-grade inflammation and depression. The hormonal profile of women is a part of this complexity, because it seems that in perimenopause the hormonal changes are accompanied by changes of acute-phase response proteins. Particularly, in perimenopausal depression, there is an interaction between HP and E2. Therefore, it seems that perimenopause is a period of a woman’s life during which hormonal, immune and metabolic changes occur and interact with each other making women vulnerable to depression.

show abstract

“…A potential reason for therapeutic failure is that dysfunction in MDD is not restricted to the brain. MDD is a systemic illness with central and peripheral inflammatory changes at the core of MDD pathology (Erdem et al, 2011; Lisi et al, 2013; Noto et al, 2014; Powell et al, 2014; Setiawan et al, 2015; Shimizu et al, 1996; Slavich and Irwin, 2014). Patients with inflammatory diseases have a higher incidence of MDD than the general population (Dickens et al, 2002; Graff et al, 2009; Krishnadas et al, 2011; Lo Fermo et al, 2010), and 20-82% of patients treated with pro-inflammatory cytokines like interferon develop MDD (Capuron et al, 2002; Krishnadas et al, 2011; Musselman et al, 2001; Reichenberg et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…MDD patients have increased blood levels of acute phase proteins and pro-inflammatory cytokines/chemokines such as IL6, IL1β, and TNFα (Dahl et al, 2014; Dowlati et al, 2010; Erdem et al, 2011; Maes et al, 1997; Maes et al, 1993b; Raison et al, 2006). These increases in pro-inflammatory cytokines positively correlate with MDD symptom severity (Howren et al, 2009; Yirmiya et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

An altered peripheral IL6 response in major depressive disorder

Money

Oláh

Korade

et al. 2016

Neurobiology of Disease

View full text Add to dashboard Cite

Major depressive disorder (MDD) is one of the most prevalent major psychiatric disorders with a lifetime prevalence of 17%. Recent evidence suggests MDD is not only a brain dysfunction, but a systemic disease affecting the whole body. Central and peripheral inflammatory changes seem to be a centerpiece of MDD pathology: a subset of patients show elevated blood cytokine and chemokine levels that partially normalize with symptom improvement over the course of antidepressant treatment. As this inflammatory process in MDD is poorly understood, we hypothesized that the peripheral tissues of MDD patients will respond differently to inflammatory stimuli, resulting in an aberrant transcriptional response to elevated proinflammatory cytokines. To test this, we used MDD patient- and control-derived dermal fibroblast cultures to investigate their response to an acute treatment with IL6, IL1β, TNFα, or vehicle. Following RNA isolation and subsequent cDNA synthesis, quantitative PCR was used to determine the relative expression level of several families of inflammation-responsive genes. Our results showed comparable expression of the tested genes between MDD patients and controls at baseline. In contrast, MDD patient fibroblasts had a diminished transcriptional response to IL6 in all the gene sets tested (oxidative stress response, mitochondrial function, and lipid metabolism). We also found a significant increase in baseline and IL6 stimulated transcript levels of the IL6 receptor gene. This IL6 receptor transcript increase in MDD fibroblasts was accompanied by an IL6 stimulated increase in induction of SOCS3, which dampens IL6 receptor signaling. Altogether our results demonstrate that there is an altered transcriptional response to IL6 in MDD, which may represent one of the molecular mechanisms contributing to disease pathophysiology. Ultimately we hope that these studies will lead to validation of novel MDD drug targets focused on normalizing the altered IL6 response in patients.

show abstract

Serum haptoglobin levels in patients with melancholic and nonmelancholic major depression

Cited by 13 publications

References 22 publications

Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

Lack of association of acute phase response proteins with hormone levels and antidepressant medication in perimenopausal depression

An altered peripheral IL6 response in major depressive disorder

Contact Info

Product

Resources

About