Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma

Kim, Chul‐Ho; Lee, Jin Seok; Kang, Sung-Ook; Bae, Jin Woo; Hong, Sung Pyo; Kahng, Hison

doi:10.1016/j.oraloncology.2006.11.016

Cited by 28 publications

(20 citation statements)

References 26 publications

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“…While HGF was found at elevated levels in over 60% of the cases, it was not a significant factor in this study; however when combined with c-Met overexpression there was a correlation with lymph node metastasis. Being a paracrine factor secreted by cells of mesenchymal origin, HGF may be more relevant as a serum biomarker, as shown in previous studies [24-26]. In these prospective studies, serum cytokine levels were measured in patients before and after treatment.…”

Section: Proteins Involved In Cell Cycle Regulation Proliferation Anmentioning

confidence: 94%

Recently Identified Biomarkers That Promote Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

Walk

Weed

2011

Cancers

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Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous cancer that arises in the upper aerodigestive tract. Despite advances in knowledge and treatment of this disease, the five-year survival rate after diagnosis of advanced (stage 3 and 4) HNSCC remains approximately 50%. One reason for the large degree of mortality associated with late stage HNSCC is the intrinsic ability of tumor cells to undergo locoregional invasion. Lymph nodes in the cervical region are the primary sites of metastasis for HNSCC, occurring before the formation of distant metastases. The presence of lymph node metastases is strongly associated with poor patient outcome, resulting in increased consideration being given to the development and implementation of anti-invasive strategies. In this review, we focus on select proteins that have been recently identified as promoters of lymph node metastasis in HNSCC. The discussed proteins are involved in a wide range of critical cellular functions, and offer a more comprehensive understanding of the factors involved in HNSCC metastasis while additionally providing increased options for consideration in the design of future therapeutic intervention strategies.

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Section: Proteins Involved In Cell Cycle Regulation Proliferation Anmentioning

confidence: 94%

Recently Identified Biomarkers That Promote Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

Walk

Weed

2011

Cancers

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“…Then patients were followed clinically to determine the prognostic value of pre-treatment biomarkers, but the biomarkers were not serially measured. 6, 9–13, 25, 26 Pre-treatment levels of cancer biomarkers can vary widely in patients with the same type of cancer. 27 Moreover, variations in cytokine secretion occur in individuals without cancer.…”

Section: Discussionmentioning

confidence: 99%

Cytokines in saliva increase in head and neck cancer patients after treatment

Russo

Bellile

Murdoch‐Kinch

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Approximately one-third of advanced squamous cell carcinoma of the head and neck (HNSCC) recur within two years of treatment. Due to ease of collection, saliva is of interest to monitor changes that correlate with treatment. Previously this was a challenge due to xerostomia following conventional radiation. The emergence of gland-sparing radiation has made it possible to collect saliva post-treatment. Objective This study investigated changes in cytokines in saliva pre- to post-treatment to provide foundational knowledge for future studies exploring the use of saliva to monitor treatment response. Study Design Pre- and post-treatment saliva was evaluated for eight cytokines by multiplex assay and ELISA. Results In oropharyngeal HNSCC, secretion of EGF, GROα, IL-1α, IL-1β, IL-6, IL-8, TNFα, and VEGF increased significantly post-treatment. In additional patients, significant increases of GROα and IL-6 were validated but EGF showed no change. Conclusions The uniqueness of this study is the comparison of salivary cytokines from HNSCC patients pre- and post-treatment.

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“…Kim et al also assessed HGF levels in the serum among healthy controls, primary HNSCC patients, and R/M HNSCC patients. This study reported a nearly 40% increase in the HGF serum levels of R/M HNSCC patients compared to healthy controls and 23% increase in nonrecurrent patients compared with controls [84]. In a study identifying therapeutic response and survival biomarkers, longitudinal changes in HGF serum levels following chemoradiation in patients with advanced HNSCC were found to significantly correlate with increased relative risk of death upon adjustment for smoking status [85].…”

Section: Relation Of the Hgf/c-met Pathway To Hnscc Outcomementioning

confidence: 99%

Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment

Rothenberger

Stabile

2017

Cancers

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Aberrant signaling of the hepatocyte growth factor (HGF)/c-Met pathway has been identified as a promoter of tumorigenesis in several tumor types including head and neck squamous cell carcinoma (HNSCC). Despite a relatively low c-Met mutation frequency, overexpression of HGF and its receptor c-Met has been observed in more than 80% of HNSCC tumors, with preclinical and clinical studies linking overexpression with cellular proliferation, invasion, migration, and poor prognosis. c-Met is activated by HGF through a paracrine mechanism to promote cellular morphogenesis enabling cells to acquire mesenchymal phenotypes in part through the epithelial-mesenchymal transition, contributing to metastasis. The HGF/c-Met pathway may also act as a resistance mechanism against epidermal growth factor receptor (EGFR) inhibition in advanced HNSCC. Furthermore, with the identification of a biologically distinct subset of HNSCC tumors acquired from human papillomavirus (HPV) infection that generally portends a good prognosis, high expression of HGF or c-Met in HPV-negative tumors has been associated with worse prognosis. Dysregulated HGF/c-Met signaling results in an aggressive HNSCC phenotype which has led to clinical investigations for targeted inhibition of this pathway. In this review, HGF/c-Met signaling, pathway alterations, associations with clinical outcomes, and preclinical and clinical therapeutic strategies for targeting HGF/c-Met signaling in HNSCC are discussed.

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Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma

Cited by 28 publications

References 26 publications

Recently Identified Biomarkers That Promote Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

Recently Identified Biomarkers That Promote Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

Cytokines in saliva increase in head and neck cancer patients after treatment

Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment

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