Serum Homocysteine as a Biomarker in Diabetes

Hyperhomocysteinemia: The Continuing Saga

“…The dimeric form of cysteine is homocysteine, or it can form 'protein-bound' homocysteine with disulphide bonds. 2 Studies have associated mild-to-moderate elevations in homocysteine with diagnosed coronary disease, myocardial infarction, cerebrovascular disease, carotid intima-media thickness and arterial disease of the lower extremities. 3,4,5,6 Observational data concluded that each 5-μmol/L increase in total homocysteine levels conferred the same increase in risk for vascular disease as a 20-mg/dL increase in total cholesterol level.…”