Serum homocysteine, folic acid and vitamin B12 levels in vitiligo

Balcı, Didem Didar; Yönden, Zafer; Yenin, Julide Zehra; Okumus, Nese

doi:10.1684/ejd.2009.0671

Cited by 21 publications

(17 citation statements)

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“…However no significant difference was observed. Very few studies evaluating blood levels of folic acid and vitamin B12 in patients with vitiligo have been reported 2 , 3 . In this study, no differences in vitamin levels between patients and controls could be found.…”

Section: Discussioncontrasting

confidence: 53%

“…Vitiligo is an acquired disorder characterized by progressive, patchy loss of pigmentation from skin, overlying hair and mucosa 1 , 2 . Several theories on vitiligo etiopathogenesis have been purposed.…”

Section: Discussionmentioning

confidence: 99%

“…Vitiligo is the most common pigmentary disorder, with a reported prevalence of 0.1–4% worlwide 1 , 2 Vitiligo has been associated with multiple endocrine and immune conditions, such us diabetes, thyroid disease or pernicious anemia (Table 1). 3 - 14 Its etiology is still unknown, although multiple hypotheses have been considered.…”

Section: Introductionmentioning

confidence: 99%

“… 3 - 14 Its etiology is still unknown, although multiple hypotheses have been considered. Three main pathogenesis mechanisms have been purposed: self-destruction, neural and autoimmune 2 - 10 . Nevertheless, vitiligo is nowadays widely considered as an autoimmune disorder 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

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When are laboratory tests indicated in patients with vitiligo?

Rodríguez-Martín

Sáez

Paz

et al. 2012

Dermato-Endocrinology

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Background: Vitiligo has been associated with multiple endocrine and immune conditions. Several laboratory tests have been assessed in this disease with controversial results. Objective: The aim of this study is to analyze the levels autoantibodies, basal glycaemia, vitamin B12, folic acid and thyroid function and its association with the diagnosis and outcome of vitiligo patients through a case-control study. Material and methods: This case-control study was performed on 196 consecutive patients with vitiligo referred to our Dermatology Department. As a control group, 160 healthy individuals without vitiligo or known history of immunologic/endocrine disease were included. Data were analyzed using the SPSS 17.0 statistical software package. Results: Clinical, analytical and demographic data have been recorded. Our results showed that anti-thyroid peroxidase antibody and anti-parietal gastric cell antibody could be useful laboratory markers in a subpopulation of vitiligo patients. However, testing anti-nuclear antibody, anti-thyroglobulin antibody, folic acid and vitamin B12 seems to have limited clinical implication and diagnostic relevance in our routine clinical practice. Limitations: This study addressed a selected population of vitiligo patients in Spain and may not generalize to different clinical settings or regions. The study of a wider sample would confirm these findings and allow a detailed analysis of the above factors as a function of the clinical subtype of vitiligo. Conclusion: We have determined the more efficient serological markers to order in vitiligo patients. Our findings suggest that anti-thyroid peroxidase antibody and anti-parietal gastric cell could be useful tests for the characterization of specific subpopulations of vitiligo patients in terms of severity and co-morbidity, so their determination could have a prognostic value.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

When are laboratory tests indicated in patients with vitiligo?

Rodríguez-Martín

Sáez

Paz

et al. 2012

Dermato-Endocrinology

View full text Add to dashboard Cite

show abstract

“…Oral L-phenylalanine (100 mg/kg/day) with phototherapy may enhance pigment via the melanin production pathway [26]. Anecdotal usage of vitamins B6, B12 and folic acid have been supported, particularly in populations with high homocysteine levels such as India, the Middle East and South America; other populations, such as Turkey, may not have an association with homocysteine levels [45,46].…”

Section: Homeopathic Therapies For Vitiligomentioning

confidence: 99%