Serum homocysteine level and gestational diabetes mellitus: A meta‐analysis

Gong, Tao; Wang, Jing; Yang, Mei; Shao, Yan; Liu, Juning; Wu, Qianlan; Xu, Qiao; Wang, Huiying; Xiu-yu, HE; Chen, Yunzhen; Xu, Rong; Wang, Yun

doi:10.1111/jdi.12460

Cited by 47 publications

(39 citation statements)

References 36 publications

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“…The evidence was more consistent among women in the second trimester and for women older than 30 years of age. As a result of physiological decreases in albumin during pregnancy, as well as in association with folic acid supplementation, the serum concentrations of homocysteine decrease during pregnancy [19,20]. Surprisingly, in our study, we did not find significant differences in those results between the GDM and control groups.…”

Section: Discussioncontrasting

confidence: 85%

Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

et al. 2019

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Objectives: Gestational diabetes mellitus (GDM) is described as a glucose intolerance of variable severity which begun or was firstly recognized during gravidity. Two major metabolic disorders, insulin resistance and β-cell dysfunction, currently play major role in pathogenesis of GDM. Our intention was to investigate total serum homocysteine and vitamin B12 levels in pregnant women with GDM and non-diabetic gravid women.Material and methods: Serum homocysteine and vitamin B12 levels were prospectively measured in a total of 79 pregnant women, 60 of whom were diagnosed with GDM, and 19 of whom were healthy controls. Serum homocysteine levels were analyzed by ELISA. Vitamin B12 concentrations were determined by chemiluminescent immunoassay, and lipids were determined enzymatically.Results: GDM and control groups did not differ in terms of the serum homocysteine levels (median 7.24 vs 7.97 umol/L, respectively, p = 0.15). Nor did we find any association between serum homocysteine levels and BMI (r = 0.06, p = 0.55, respectively). There was no correlation between serum homocysteine and fasting serum glucose (r = 0.3, p = 0.8, respectively). There was no relationship between serum homocysteine concentrations and glycosylated hemoglobin (HgbA1c) levels (r = 0.06, p = 0.67, respectively). Serum vitamin B12 concentrations did not differ between the GDM and control groups (median 286 vs 262 pg/mL, respectively, p = 0.17). We found that levels of Vitamin B12 correlated inversely with fasting serum glucose concentrations (r = -0.44, p = 0.0009). Vitamin B12 concentrations increased along with LDL (r = 0.27, p = 0.043) and HDL (r = 0.38, p = 0.004) levels, however were inversely correlated with serum triglycerides (r = -0.34, p = 0.009). Conclusions: GDM patients with lowVitamin B12 values tend to have higher fasting serum glucose and altered lipid profiles (high triglycerides, low HDL and LDL). In women with GDM, serum homocysteine levels are not associated with HbA1c level, fasting glycemia, or BMI.

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Section: Discussioncontrasting

confidence: 85%

Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

et al. 2019

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“…A recent meta-analysis examined the relationship between serum homocysteine concentration and GDM in ten eligible studies. The authors reported significantly higher homocysteine concentrations among women with GDM as compared with those without GDM [ 146 ]. B vitamins, including folic acid, B2, B6, and B12 are essential for homocysteine homeostasis, and this may be one reason why deficiencies and imbalances of these micronutrients are associated with GDM [ 147 ].…”

Section: Pathophysiology Of Gestational Diabetesmentioning

confidence: 99%

The Pathophysiology of Gestational Diabetes Mellitus

Plows

Stanley

Baker

et al. 2018

IJMS

1,199

914

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Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance. Risk factors for GDM include overweight and obesity, advanced maternal age, and a family history or any form of diabetes. Consequences of GDM include increased risk of maternal cardiovascular disease and type 2 diabetes and macrosomia and birth complications in the infant. There is also a longer-term risk of obesity, type 2 diabetes, and cardiovascular disease in the child. GDM affects approximately 16.5% of pregnancies worldwide, and this number is set to increase with the escalating obesity epidemic. While several management strategies exist—including insulin and lifestyle interventions—there is not yet a cure or an efficacious prevention strategy. One reason for this is that the molecular mechanisms underlying GDM are poorly defined. This review discusses what is known about the pathophysiology of GDM, and where there are gaps in the literature that warrant further exploration.

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“…Gestational diabetes mellitus (GDM) is a metabolic complication with glucose intolerance during pregnancy. High plasma level of Hcy was found in pregnant women with GDM as compared to nonpregnant women with normal glucose tolerance (Gong et al., 2016). (Tarim et al., 2004) conducted a study to determine whether elevated plasma Hcy is associated with GDM in Turkish women and found that women with gestational diabetes with abnormal screening test results but normal oral glucose tolerance test results have higher Hcy levels than normal pregnant women.…”

Section: Cysteine and Homocysteine As Biomarker Of Various Diseasesmentioning

confidence: 99%

Cysteine and homocysteine as biomarker of various diseases

Rehman

Shabbir

Inam‐Ur‐Raheem

et al. 2020

Food Science & Nutrition

187

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Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine. This article aims to highlight the link between cysteine and Hcy, and their mechanisms, important functions, play in the body and their role as a biomarker for various types of diseases. So that using cysteine and Hcy as a biomarker, we can prevent and diagnose many diseases. This review concluded that hyperhomocysteinemia (elevated levels of homocysteine) is considered as toxic for cells and is associated with different health problems. Hyperhomocysteinemia and low levels of cysteine associated with various diseases like cardiovascular diseases (CVD), ischemic stroke, neurological disorders, diabetes, cancer like lung and colorectal cancer, renal dysfunction‐linked conditions, and vitiligo.

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Serum homocysteine level and gestational diabetes mellitus: A meta‐analysis

Cited by 47 publications

References 36 publications

Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

Serum homocysteine and vitamin B12 levels in women with gestational diabetes mellitus

The Pathophysiology of Gestational Diabetes Mellitus

Cysteine and homocysteine as biomarker of various diseases

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