Serum homocysteine levels are increased in women with gestational diabetes mellitus

Early onset of subclinical atherosclerosis in women with gestational diabetes mellitus

“…Increased homocysteine levels were shown in gestational diabetes that is mainly related to 2-h OGTT plasma glucose 39 . In this study, although homocysteine levels were higher in patients with GDM, we could not find any relation between homocysteine levels and CIMT.…”

Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

“…Homocysteine and folate have essential roles in metabolism by supplying one carbon units for methylation reactions. Hence impaired homocysteine and folate metabolism is associated not only with cardiovascular disease but also with a wide range of common diseases like neural tube defects, congenital birth defects, congenital heart disease, late pregnancy complications, different kinds of neurodegenerative and psychiatric diseases and cancer [17][18][19][20]. Previous studies showed that hyperhomocysteinemia is associated with an increased risk of pregnancy complications like pre-eclampsia and gestational diabetes mellitus [21][22][23][24].…”

Gestational Diabetes and the Metabolic Syndrome

“…Limited evidence exists for the association between uric acid and GDM, although its predictive value in T2DM makes it a promising candidate for studies of GDM. High uric acid levels have been detected in women with GDM (Seghieri et al, 2003), and are considered a marker of preeclampsia (Barden et al, 2004). SHBG (Smirnakis et al, 2007) is another biochemical marker of much interest.…”